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The effects of oral ferrous bisglycinate supplementation on hemoglobin and ferritin concentrations in adults and children: a systematic review and meta-analysis of randomized controlled trials.
Fischer JAJ, Cherian AM, Bone JN, Karakochuk CD. Fischer JAJ, et al. Nutr Rev. 2023 Jul 10;81(8):904-920. doi: 10.1093/nutrit/nuac106. Nutr Rev. 2023. PMID: 36728680 Free PMC article.
CONCLUSION: Ferrous bisglycinate shows some benefit over other iron supplements in increasing hemoglobin concentration and reducing GI adverse events among pregnant women. More trials are needed to assess the efficacy of ferrous bisglycinate against ot …
CONCLUSION: Ferrous bisglycinate shows some benefit over other iron supplements in increasing hemoglobin concentration and red …
Efficacy and Safety of Ferrous Bisglycinate and Folinic Acid in the Control of Iron Deficiency in Pregnant Women: A Randomized, Controlled Trial.
Bumrungpert A, Pavadhgul P, Piromsawasdi T, Mozafari MR. Bumrungpert A, et al. Nutrients. 2022 Jan 20;14(3):452. doi: 10.3390/nu14030452. Nutrients. 2022. PMID: 35276810 Free PMC article. Clinical Trial.
The objective of this randomized, controlled trial was to examine the bioavailability, efficacy, and safety of oral ferrous bisglycinate plus folinic acid supplementation in pregnant women with iron deficiency. Subjects (1216 weeks of gestation, n = 120) were random …
The objective of this randomized, controlled trial was to examine the bioavailability, efficacy, and safety of oral ferrous bisgly …
Low-dose ferrous bisglycinate chelate supplementation in chronic kidney disease and hemodialysis patients.
Hsu CY, Chen JC, Tsai YC, Chen TW. Hsu CY, et al. J Chin Med Assoc. 2022 May 1;85(5):566-570. doi: 10.1097/JCMA.0000000000000725. Epub 2022 Mar 31. J Chin Med Assoc. 2022. PMID: 35358119 Clinical Trial.
METHODS: We conducted an open-label trial to study the efficiency of a film-coated iron supplementation tablet, which contains ferrous bisglycinate chelate, vitamin C, and folic acid, in CKD stage 3b to 4 and HD patients. ...No GI upset events were reported. CONCLUS …
METHODS: We conducted an open-label trial to study the efficiency of a film-coated iron supplementation tablet, which contains ferrous …
Is a Lower Dose of More Bioavailable Iron (18-mg Ferrous Bisglycinate) Noninferior to 60-mg Ferrous Sulfate in Increasing Ferritin Concentrations While Reducing Gut Inflammation and Enteropathogen Detection in Cambodian Women? A Randomized Controlled Noninferiority Trial.
Fischer JAJ, Pei LX, Elango R, Hou K, Goldfarb DM, Karakochuk CD. Fischer JAJ, et al. J Nutr. 2023 Aug;153(8):2453-2462. doi: 10.1016/j.tjnut.2023.05.029. Epub 2023 Jun 2. J Nutr. 2023. PMID: 37271416 Clinical Trial.
Nonpregnant women (n = 480, 18-45 y) were randomly assigned to 60-mg ferrous sulfate, 18-mg ferrous bisglycinate, or placebo for 12 wk. Nonfasting blood and stool specimens were collected at baseline and 12 wk. ...Mean ferritin concentration at 12 wk was higher in t …
Nonpregnant women (n = 480, 18-45 y) were randomly assigned to 60-mg ferrous sulfate, 18-mg ferrous bisglycinate, or placebo f …
Ferrous Bisglycinate Supplementation Modulates Intestinal Antioxidant Capacity via the AMPK/FOXO Pathway and Reconstitutes Gut Microbiota and Bile Acid Profiles in Pigs.
Dong Z, Zhang D, Wu X, Yin Y, Wan D. Dong Z, et al. J Agric Food Chem. 2022 Apr 27;70(16):4942-4951. doi: 10.1021/acs.jafc.2c00138. Epub 2022 Apr 14. J Agric Food Chem. 2022. PMID: 35420025
Multi-omics were applied to compare the risks and benefits of ferrous sulfate (FeSO(4)) and ferrous bisglycinate (FebisGly) in pigs in the current study. The FebisGly group showed reduced triglyceride (TG) and triglyceride/total cholesterol (TG/CHOL) values in the s …
Multi-omics were applied to compare the risks and benefits of ferrous sulfate (FeSO(4)) and ferrous bisglycinate (FebisGly) in …
Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells.
Yu X, Chen L, Ding H, Zhao Y, Feng J. Yu X, et al. Nutrients. 2019 Feb 26;11(3):485. doi: 10.3390/nu11030485. Nutrients. 2019. PMID: 30813537 Free PMC article.
This experiment was conducted to investigate the transport characteristics of iron from ferrous bisglycinate (Fe-Gly) in intestinal cells. The divalent metal transporter 1 (DMT1)-knockout Caco-2 cell line was developed by Crispr-Cas9, and then the cells were treated …
This experiment was conducted to investigate the transport characteristics of iron from ferrous bisglycinate (Fe-Gly) in intes …
Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial.
Milman N, Jønsson L, Dyre P, Pedersen PL, Larsen LG. Milman N, et al. J Perinat Med. 2014 Mar;42(2):197-206. doi: 10.1515/jpm-2013-0153. J Perinat Med. 2014. PMID: 24152889 Clinical Trial.
OBJECTIVE: To compare the effects of oral ferrous bisglycinate 25 mg iron/day vs. ferrous sulfate 50 mg iron/day in the prevention of iron deficiency (ID) and iron deficiency anemia (IDA) in pregnant women. ...Newborns weight was slightly higher in the bisglycinate …
OBJECTIVE: To compare the effects of oral ferrous bisglycinate 25 mg iron/day vs. ferrous sulfate 50 mg iron/day in the preven …
Iron absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status.
Bovell-Benjamin AC, Viteri FE, Allen LH. Bovell-Benjamin AC, et al. Am J Clin Nutr. 2000 Jun;71(6):1563-9. doi: 10.1093/ajcn/71.6.1563. Am J Clin Nutr. 2000. PMID: 10837299
OBJECTIVE: The objective of this study was to compare iron absorption from ferrous sulfate, ferrous bisglycinate, and ferric trisglycinate in whole-maize meal; to determine whether iron from ferrous bisglycinate and ferrous sulfate exchanges in the int …
OBJECTIVE: The objective of this study was to compare iron absorption from ferrous sulfate, ferrous bisglycinate, and ferric t …
Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate.
Ferrari P, Nicolini A, Manca ML, Rossi G, Anselmi L, Conte M, Carpi A, Bonino F. Ferrari P, et al. Biomed Pharmacother. 2012 Sep;66(6):414-8. doi: 10.1016/j.biopha.2012.06.003. Epub 2012 Jun 29. Biomed Pharmacother. 2012. PMID: 22795809 Clinical Trial.
AEs occurred in six cases. In all these six cases, two (17%) treated with ferrous bisglycinate chelate and four (33%) with ferrous sulphate, toxicity was grade 1. In conclusion, these data suggest that ferrous bisglycinate chelate has similar efficacy …
AEs occurred in six cases. In all these six cases, two (17%) treated with ferrous bisglycinate chelate and four (33%) with fer …
Safety evaluation of ferrous bisglycinate chelate.
Jeppsen RB, Borzelleca JF. Jeppsen RB, et al. Food Chem Toxicol. 1999 Jul;37(7):723-31. doi: 10.1016/s0278-6915(99)00052-6. Food Chem Toxicol. 1999. PMID: 10496373
Ferrous bisglycinate chelate (Ferrochel) is a highly stable chelate that can be added to most foods. ...The acute oral LD50 for male and female Sprague-Dawley (S-D) rats is 2800 mg/kg body weight (560 mg/kg body weight iron [confidence limit (CL) 399-786] as the act …
Ferrous bisglycinate chelate (Ferrochel) is a highly stable chelate that can be added to most foods. ...The acute oral LD50 fo …
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