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Year Number of Results
1962 1
1977 2
1980 1
1990 3
1991 1
1992 1
1993 5
1994 1
1996 6
1997 3
1998 3
1999 5
2000 3
2001 7
2002 10
2003 11
2004 3
2005 7
2006 17
2007 22
2008 8
2009 11
2010 14
2011 30
2012 27
2013 20
2014 23
2015 27
2016 27
2017 19
2018 24
2019 20
2020 21
2021 24
2022 20
2023 23
2024 12

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422 results

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Page 1
Nebulised hypertonic saline for cystic fibrosis.
Wark P, McDonald VM, Smith S. Wark P, et al. Cochrane Database Syst Rev. 2023 Jun 14;6(6):CD001506. doi: 10.1002/14651858.CD001506.pub5. Cochrane Database Syst Rev. 2023. PMID: 37319354 Review.
Hypertonic saline versus control (acute exacerbation) Two trials compared hypertonic saline to control, but only one provided data. ...No other outcomes were reported in the review. Hypertonic saline 7% versus hypertonic saline
Hypertonic saline versus control (acute exacerbation) Two trials compared hypertonic saline to control, but only
Nebulised hypertonic saline for cystic fibrosis.
Wark P, McDonald VM. Wark P, et al. Cochrane Database Syst Rev. 2018 Sep 27;9(9):CD001506. doi: 10.1002/14651858.CD001506.pub4. Cochrane Database Syst Rev. 2018. PMID: 30260472 Free PMC article. Updated. Review.
BACKGROUND: Impaired mucociliary clearance characterises lung disease in cystic fibrosis (CF). Hypertonic saline enhances mucociliary clearance and may lessen the destructive inflammatory process in the airways. ...Cough and wheeze were reported but no seriou …
BACKGROUND: Impaired mucociliary clearance characterises lung disease in cystic fibrosis (CF). Hypertonic saline enhanc …
Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials.
Mayer-Hamblett N, Ratjen F, Russell R, Donaldson SH, Riekert KA, Sawicki GS, Odem-Davis K, Young JK, Rosenbluth D, Taylor-Cousar JL, Goss CH, Retsch-Bogart G, Clancy JP, Genatossio A, O'Sullivan BP, Berlinski A, Millard SL, Omlor G, Wyatt CA, Moffett K, Nichols DP, Gifford AH; SIMPLIFY Study Group. Mayer-Hamblett N, et al. Lancet Respir Med. 2023 Apr;11(4):329-340. doi: 10.1016/S2213-2600(22)00434-9. Epub 2022 Nov 4. Lancet Respir Med. 2023. PMID: 36343646 Free PMC article. Clinical Trial.
Participants on both hypertonic saline and dornase alfa were randomly assigned to one of the two trials, and those on a single therapy were assigned to the applicable trial. ...INTERPRETATION: In individuals with cystic fibrosis on ETI with relatively well pr …
Participants on both hypertonic saline and dornase alfa were randomly assigned to one of the two trials, and those on a single …
Timing of hypertonic saline inhalation for cystic fibrosis.
Elkins M, Dentice R. Elkins M, et al. Cochrane Database Syst Rev. 2016 Dec;12(12):CD008816. doi: 10.1002/14651858.CD008816.pub3. Epub 2016 Dec 22. Cochrane Database Syst Rev. 2016. PMID: 28146603 Free PMC article. Updated. Review.
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical outcomes of people with cystic fibrosis. ...Given the long-term efficacy of hypertonic saline has only been established …
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical …
Efficacy of hypertonic saline versus isotonic saline among children with cystic fibrosis: A systematic review and meta-analysis.
Ullah SE, Zahoor MM, Gupta S, Boparai S, Muneeb M, Eltieb SAH, Shankar A, Kidiavai HM, Vohra RR, Devi A, Bhura ZA, Aslam ZM, Shoaib M. Ullah SE, et al. Can J Respir Ther. 2023 Jan 20;59:1-7. doi: 10.29390/cjrt-2022-046. eCollection 2023. Can J Respir Ther. 2023. PMID: 36711047 Free PMC article. Review.
BACKGROUND: Inhaled hypertonic saline (HS) reduces pulmonary exacerbations in patients with cystic fibrosis (CF) aged 6 or more years. ...Trials involving only patients greater than 6 years or control group other than isotonic saline (IS) were excluded …
BACKGROUND: Inhaled hypertonic saline (HS) reduces pulmonary exacerbations in patients with cystic fibrosis (CF) aged 6 …
Timing of hypertonic saline inhalation for cystic fibrosis.
Elkins M, Dentice R. Elkins M, et al. Cochrane Database Syst Rev. 2020 Feb 28;2(2):CD008816. doi: 10.1002/14651858.CD008816.pub4. Cochrane Database Syst Rev. 2020. PMID: 32107770 Free PMC article.
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical outcomes of people with cystic fibrosis. ...However, inhaling hypertonic saline before or during airway clearance techn …
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical …
Cystic fibrosis.
O'Sullivan BP, Freedman SD. O'Sullivan BP, et al. Lancet. 2009 May 30;373(9678):1891-904. doi: 10.1016/S0140-6736(09)60327-5. Epub 2009 May 4. Lancet. 2009. PMID: 19403164 Review.
Cystic fibrosis is the most common lethal genetic disease in white populations. ...One of these treatments, hypertonic saline, is already in use, whereas others are in advanced stages of development. ...
Cystic fibrosis is the most common lethal genetic disease in white populations. ...One of these treatments, hypertonic sali
Timing of hypertonic saline inhalation for cystic fibrosis.
Elkins M, Dentice R. Elkins M, et al. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD008816. doi: 10.1002/14651858.CD008816.pub2. Cochrane Database Syst Rev. 2012. PMID: 22336853 Review.
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical outcomes of people with cystic fibrosis. OBJECTIVES: To determine whether the timing of hypertonic saline inhalation (i …
BACKGROUND: Inhalation of hypertonic saline improves sputum rheology, accelerates mucociliary clearance and improves clinical …
Hypertonic saline for cystic fibrosis: worth its salt?
Goralski JL, Donaldson SH. Goralski JL, et al. Expert Rev Respir Med. 2014 Jun;8(3):267-9. doi: 10.1586/17476348.2014.896203. Epub 2014 Mar 26. Expert Rev Respir Med. 2014. PMID: 24666113
Restoration of airway hydration by inhalation of an osmotic agent (hypertonic saline) has been shown to be safe, effective and well-tolerated in adults with CF. ...In this editorial, we discuss the evidence behind hypertonic saline use for adults, chil …
Restoration of airway hydration by inhalation of an osmotic agent (hypertonic saline) has been shown to be safe, effective and …
Hypertonic saline in treatment of pulmonary disease in cystic fibrosis.
Reeves EP, Molloy K, Pohl K, McElvaney NG. Reeves EP, et al. ScientificWorldJournal. 2012;2012:465230. doi: 10.1100/2012/465230. Epub 2012 May 3. ScientificWorldJournal. 2012. PMID: 22645424 Free PMC article. Review.
Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline. It has been shown that hypertonic saline possesses mucolytic properties and aids mucociliary clearance by restoring the liquid layer lining the airwa …
Therapies acting against airway mucus in cystic fibrosis include aerosolized hypertonic saline. It has been shown that …
422 results