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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1786 1
1805 1
1829 1
1831 1
1832 1
1833 1
1837 1
1838 2
1843 1
1844 5
1845 1
1849 1
1854 3
1855 2
1856 1
1858 2
1859 2
1860 3
1861 2
1867 1
1868 1
1873 5
1875 2
1876 1
1878 1
1879 1
1880 1
1881 5
1882 5
1884 4
1885 2
1886 5
1888 1
1889 1
1892 1
1893 1
1894 3
1896 2
1897 4
1900 3
1903 1
1905 2
1906 2
1907 2
1909 1
1910 1
1911 1
1912 1
1914 1
1916 2
1918 1
1920 1
1922 1
1923 3
1924 2
1925 2
1926 4
1927 3
1928 2
1929 1
1930 4
1932 2
1933 2
1934 1
1935 3
1936 1
1938 3
1939 6
1940 1
1941 2
1942 3
1943 2
1944 1
1945 3
1946 12
1947 28
1948 12
1949 9
1950 14
1951 15
1952 18
1953 23
1954 20
1955 13
1956 17
1957 15
1958 15
1959 23
1960 17
1961 30
1962 26
1963 46
1964 76
1965 57
1966 69
1967 133
1968 94
1969 74
1970 88
1971 94
1972 89
1973 83
1974 106
1975 167
1976 141
1977 132
1978 171
1979 173
1980 185
1981 183
1982 215
1983 209
1984 288
1985 290
1986 247
1987 303
1988 308
1989 323
1990 371
1991 374
1992 407
1993 460
1994 394
1995 409
1996 512
1997 564
1998 608
1999 600
2000 790
2001 816
2002 966
2003 1087
2004 1195
2005 1339
2006 1437
2007 1651
2008 1762
2009 1912
2010 2152
2011 2057
2012 2196
2013 2478
2014 2622
2015 2805
2016 2878
2017 3025
2018 3375
2019 3524
2020 4038
2021 4700
2022 4931
2023 5183
2024 4505
2025 3

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65,970 results

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Page 1
Longevity: Lesson from Model Organisms.
Taormina G, Ferrante F, Vieni S, Grassi N, Russo A, Mirisola MG. Taormina G, et al. Genes (Basel). 2019 Jul 9;10(7):518. doi: 10.3390/genes10070518. Genes (Basel). 2019. PMID: 31324014 Free PMC article. Review.
Research on longevity and healthy aging promises to increase our lifespan and decrease the burden of degenerative diseases with important social and economic effects. ...Here, we review conserved aging mechanisms discovered in different model systems that are implicated in …
Research on longevity and healthy aging promises to increase our lifespan and decrease the burden of degenerative diseases with impor …
Genetics of healthy aging and longevity.
Brooks-Wilson AR. Brooks-Wilson AR. Hum Genet. 2013 Dec;132(12):1323-38. doi: 10.1007/s00439-013-1342-z. Epub 2013 Aug 8. Hum Genet. 2013. PMID: 23925498 Free PMC article. Review.
Linkage studies of exceptionally long-lived families now support a longevity locus on chromosome 3; other putative longevity loci differ between studies. Candidate gene studies have identified variants at APOE and FOXO3A associated with longevity; other genes …
Linkage studies of exceptionally long-lived families now support a longevity locus on chromosome 3; other putative longevity l …
Dietary Phytochemicals that Can Extend Longevity by Regulation of Metabolism.
Shen J, Shan J, Zhong L, Liang B, Zhang D, Li M, Tang H. Shen J, et al. Plant Foods Hum Nutr. 2022 Mar;77(1):12-19. doi: 10.1007/s11130-021-00946-z. Epub 2022 Jan 13. Plant Foods Hum Nutr. 2022. PMID: 35025006 Free PMC article. Review.
Extensive studies have shown that the major components of diet, such as protein, carbohydrate and fat, play important roles in regulating aging and longevity. Whether other dietary ingredients can help prevent aging and extend longevity is a very interesting questio …
Extensive studies have shown that the major components of diet, such as protein, carbohydrate and fat, play important roles in regulating ag …
Cardiovascular Aging and Longevity: JACC State-of-the-Art Review.
Pietri P, Stefanadis C. Pietri P, et al. J Am Coll Cardiol. 2021 Jan 19;77(2):189-204. doi: 10.1016/j.jacc.2020.11.023. J Am Coll Cardiol. 2021. PMID: 33446313 Free article. Review.
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia …
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atheroscler …
How Important Are Genes to Achieve Longevity?
Caruso C, Ligotti ME, Accardi G, Aiello A, Duro G, Galimberti D, Candore G. Caruso C, et al. Int J Mol Sci. 2022 May 18;23(10):5635. doi: 10.3390/ijms23105635. Int J Mol Sci. 2022. PMID: 35628444 Free PMC article. Review.
Several studies on the genetics of longevity have been reviewed in this paper. The results show that, despite efforts and new technologies, only two genes, APOE and FOXO3A, involved in the protection of cardiovascular diseases, have been shown to be associated with long …
Several studies on the genetics of longevity have been reviewed in this paper. The results show that, despite efforts and new technol …
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance.
Takasugi M, Ohtani N, Takemura K, Emmrich S, Zakusilo FT, Yoshida Y, Kutsukake N, Mariani JN, Windrem MS, Chandler-Militello D, Goldman SA, Satoh J, Ito S, Seluanov A, Gorbunova V. Takasugi M, et al. Cell Rep. 2023 Sep 26;42(9):113130. doi: 10.1016/j.celrep.2023.113130. Epub 2023 Sep 13. Cell Rep. 2023. PMID: 37708026 Free PMC article.
Notably, expression levels of CD44, an ECM-binding protein that has been suggested to contribute to NMR longevity by mediating the effect of hyaluronan (HA), are not only high in OPCs of long-lived species but also positively correlate with longevity in multiple cel …
Notably, expression levels of CD44, an ECM-binding protein that has been suggested to contribute to NMR longevity by mediating the ef …
Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans.
Kunugi H, Mohammed Ali A. Kunugi H, et al. Int J Mol Sci. 2019 Sep 20;20(19):4662. doi: 10.3390/ijms20194662. Int J Mol Sci. 2019. PMID: 31547049 Free PMC article. Review.
RJ and its ingredients-proteins and their derivatives e.g., royalactin; lipids e.g., 10-hydroxydecenoic acid; and vitamins e.g., pantothenic acid-improved healthspan and extended lifespan in worker honeybees Apis mellifera, Drosophila Melanogaster flies, Gryllus bimaculatus crick …
RJ and its ingredients-proteins and their derivatives e.g., royalactin; lipids e.g., 10-hydroxydecenoic acid; and vitamins e.g., pantothenic …
Global analysis of aging-related protein structural changes uncovers enzyme-polymerization-based control of longevity.
Paukštytė J, López Cabezas RM, Feng Y, Tong K, Schnyder D, Elomaa E, Gregorova P, Doudin M, Särkkä M, Sarameri J, Lippi A, Vihinen H, Juutila J, Nieminen A, Törönen P, Holm L, Jokitalo E, Krisko A, Huiskonen J, Sarin LP, Hietakangas V, Picotti P, Barral Y, Saarikangas J. Paukštytė J, et al. Mol Cell. 2023 Sep 21;83(18):3360-3376.e11. doi: 10.1016/j.molcel.2023.08.015. Epub 2023 Sep 11. Mol Cell. 2023. PMID: 37699397 Free article.
An epigenetic biomarker of aging for lifespan and healthspan.
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. Levine ME, et al. Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414. Aging (Albany NY). 2018. PMID: 29676998 Free PMC article.
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