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528 results

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Page 1
1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype.
Plastira I, Bernhart E, Goeritzer M, Reicher H, Kumble VB, Kogelnik N, Wintersperger A, Hammer A, Schlager S, Jandl K, Heinemann A, Kratky D, Malle E, Sattler W. Plastira I, et al. J Neuroinflammation. 2016 Aug 26;13(1):205. doi: 10.1186/s12974-016-0701-9. J Neuroinflammation. 2016. PMID: 27565558 Free PMC article.
BACKGROUND: Microglia, the immunocompetent cells of the CNS, rapidly respond to brain injury and disease by altering their morphology and phenotype to adopt an activated state. ...The objective of the present study was to determine the outcome of lysophosphatidic …
BACKGROUND: Microglia, the immunocompetent cells of the CNS, rapidly respond to brain injury and disease by altering their morphology …
MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia.
Plastira I, Bernhart E, Joshi L, Koyani CN, Strohmaier H, Reicher H, Malle E, Sattler W. Plastira I, et al. J Neuroinflammation. 2020 Apr 23;17(1):127. doi: 10.1186/s12974-020-01809-1. J Neuroinflammation. 2020. PMID: 32326963 Free PMC article.
BACKGROUND: In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. ...METHODS: In vivo, LPAR1-6 expression was established by qPCR in whole murine brain homog …
BACKGROUND: In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated h …
Lysophosphatidic Acid and Glutamatergic Transmission.
Roza C, Campos-Sandoval JA, Gómez-García MC, Peñalver A, Márquez J. Roza C, et al. Front Mol Neurosci. 2019 May 28;12:138. doi: 10.3389/fnmol.2019.00138. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31191247 Free PMC article.
Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in neurons and glial cells by affecting key …
Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane …
Disrupted Blood-Brain Barrier and Mitochondrial Impairment by Autotaxin-Lysophosphatidic Acid Axis in Postischemic Stroke.
Bhattarai S, Sharma S, Ara H, Subedi U, Sun G, Li C, Bhuiyan MS, Kevil C, Armstrong WP, Minvielle MT, Miriyala S, Panchatcharam M. Bhattarai S, et al. J Am Heart Assoc. 2021 Sep 21;10(18):e021511. doi: 10.1161/JAHA.121.021511. Epub 2021 Sep 13. J Am Heart Assoc. 2021. PMID: 34514847 Free PMC article.
Adjunct therapeutic targets for reperfusion in ischemic stroke are in need to prevent blood-brain barrier disruption. Recently, we have shown that endothelial permeability is mediated by lysophosphatidic acid (LPA), but the role of autotaxin, which produces L …
Adjunct therapeutic targets for reperfusion in ischemic stroke are in need to prevent blood-brain barrier disruption. Recently, we ha …
Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice.
Gao L, Peng L, Sherchan P, Tang H, Liu Y, Xiao J, Shi H, Luo Y, Tang J, Zhang JH, Xia Y. Gao L, et al. Fluids Barriers CNS. 2023 May 10;20(1):33. doi: 10.1186/s12987-023-00434-3. Fluids Barriers CNS. 2023. PMID: 37165450 Free PMC article.
BACKGROUD: The frequencies of morbidity and impairment associated with spontaneous intracerebral haemorrhage (ICH) are comparatively high. Blood-brain barrier (BBB) integrity was compromised due to subsequent brain injury induced by ICH, which is crucial for a poor …
BACKGROUD: The frequencies of morbidity and impairment associated with spontaneous intracerebral haemorrhage (ICH) are comparatively high. B …
The pharmacological actions of Danzhi-xiaoyao-San on depression involve lysophosphatidic acid and microbiota-gut-brain axis: novel insights from a systems pharmacology analysis of a double-blind, randomized, placebo-controlled clinical trial.
Zhu X, Wu S, Zhou Y, Xiao T, Xia L, Wang Y, Xiao A, Guo J, Zhang M, Wen Y, Shang D, Yu L. Zhu X, et al. J Biomol Struct Dyn. 2023 Aug 26:1-16. doi: 10.1080/07391102.2023.2251067. Online ahead of print. J Biomol Struct Dyn. 2023. PMID: 37632305
The active ingredients quercetin and luteolin were docked to targets (AVPR2, EGFR, F2, and CDK6) associated with the enriched pathways 'pancreatic cancer' and 'phospholipase D signaling pathway', which included the metabolite lysophosphatidic acid [LPA(0:0/16:0)]. A …
The active ingredients quercetin and luteolin were docked to targets (AVPR2, EGFR, F2, and CDK6) associated with the enriched pathways 'panc …
Lysophosphatidic Acid Signalling in Nervous System Development and Function.
Birgbauer E. Birgbauer E. Neuromolecular Med. 2021 Mar;23(1):68-85. doi: 10.1007/s12017-020-08630-2. Epub 2020 Nov 5. Neuromolecular Med. 2021. PMID: 33151452 Review.
One class of molecules that are now coming to be recognized as essential for our understanding of the nervous system are the lysophospholipids. One of the major signaling lysophospholipids is lysophosphatidic acid, also known as LPA. LPA activates a variety of G pro …
One class of molecules that are now coming to be recognized as essential for our understanding of the nervous system are the lysophospholipi …
Microglial lysophosphatidic acid promotes glioblastoma proliferation and migration via LPA(1) receptor.
Amaral RF, Geraldo LHM, Einicker-Lamas M, E Spohr TCLS, Mendes F, Lima FRS. Amaral RF, et al. J Neurochem. 2021 Feb;156(4):499-512. doi: 10.1111/jnc.15097. Epub 2020 Jun 20. J Neurochem. 2021. PMID: 32438456 Free article.
Glioblastomas (GBMs) are highly aggressive primary brain tumors characterized by cellular heterogeneity, insensitivity to chemotherapy and poor patient survival. Lysophosphatidic acid (LPA) is a lysophospholipid that acts as a bioactive signaling molecule and …
Glioblastomas (GBMs) are highly aggressive primary brain tumors characterized by cellular heterogeneity, insensitivity to chemotherap …
Lysophosphatidic acid and amitriptyline signal through LPA1R to reduce P-glycoprotein transport at the blood-brain barrier.
Banks DB, Chan GN, Evans RA, Miller DS, Cannon RE. Banks DB, et al. J Cereb Blood Flow Metab. 2018 May;38(5):857-868. doi: 10.1177/0271678X17705786. Epub 2017 Apr 27. J Cereb Blood Flow Metab. 2018. PMID: 28447863 Free PMC article.
The blood-brain barrier is a microvascular network that (1) provides neuroprotection from metabolic and environmental toxins and (2) limits the delivery of therapeutics to the central nervous system (CNS). ...We provide a novel mechanism to achieve this end in functioning, …
The blood-brain barrier is a microvascular network that (1) provides neuroprotection from metabolic and environmental toxins and (2) …
Autotaxin-Lysophosphatidic Acid Signaling in Alzheimer's Disease.
Ramesh S, Govindarajulu M, Suppiramaniam V, Moore T, Dhanasekaran M. Ramesh S, et al. Int J Mol Sci. 2018 Jun 21;19(7):1827. doi: 10.3390/ijms19071827. Int J Mol Sci. 2018. PMID: 29933579 Free PMC article. Review.
Autotaxin (ATX) is an ecto-nucleotide pyrophosphatase/phosphodiesterase-2 enzyme that hydrolyzes extracellular lysophospholipids into the lipid mediator lysophosphatidic acid (LPA). LPA is a major bioactive lipid which acts through G protein-coupled receptors (GPCRs …
Autotaxin (ATX) is an ecto-nucleotide pyrophosphatase/phosphodiesterase-2 enzyme that hydrolyzes extracellular lysophospholipids into the li …
528 results