Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 4
1947 1
1948 2
1949 5
1950 2
1951 3
1952 1
1953 2
1954 13
1955 9
1956 8
1957 6
1958 5
1959 5
1960 3
1961 3
1962 2
1963 4
1964 6
1965 16
1966 6
1967 7
1968 15
1969 18
1970 18
1971 13
1972 14
1973 10
1974 14
1975 21
1976 11
1977 7
1978 13
1979 19
1980 17
1981 24
1982 25
1983 34
1984 36
1985 26
1986 19
1987 30
1988 13
1989 21
1990 18
1991 33
1992 18
1993 17
1994 31
1995 38
1996 34
1997 32
1998 33
1999 54
2000 32
2001 31
2002 32
2003 42
2004 51
2005 64
2006 74
2007 77
2008 54
2009 72
2010 69
2011 83
2012 82
2013 81
2014 89
2015 84
2016 78
2017 132
2018 110
2019 84
2020 92
2021 104
2022 84
2023 83
2024 46

Text availability

Article attribute

Article type

Publication date

Search Results

2,380 results

Results by year

Filters applied: . Clear all
Page 1
Manganese neurotoxicity.
Dobson AW, Erikson KM, Aschner M. Dobson AW, et al. Ann N Y Acad Sci. 2004 Mar;1012:115-28. doi: 10.1196/annals.1306.009. Ann N Y Acad Sci. 2004. PMID: 15105259 Review.
While manganese deficiency rarely occurs in humans, manganese toxicity is known to occur in certain occupational settings through inhalation of manganese-containing dust. ...It has been proposed that populations already at heightened risk for neurodegeneratio …
While manganese deficiency rarely occurs in humans, manganese toxicity is known to occur in certain occupational settings thro …
The early history of manganese and the recognition of its neurotoxicity, 1837-1936.
Blanc PD. Blanc PD. Neurotoxicology. 2018 Jan;64:5-11. doi: 10.1016/j.neuro.2017.04.006. Epub 2017 Apr 14. Neurotoxicology. 2018. PMID: 28416395 Review.
The history of the biomedical recognition manganese-caused neurotoxicity mirrors changing technologies as much as it does the ontology of parkinsonism. ...As the 19th century progressed, technological change in steel fabrication requiring higher manganese con …
The history of the biomedical recognition manganese-caused neurotoxicity mirrors changing technologies as much as it does the …
Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update.
Tinkov AA, Paoliello MMB, Mazilina AN, Skalny AV, Martins AC, Voskresenskaya ON, Aaseth J, Santamaria A, Notova SV, Tsatsakis A, Lee E, Bowman AB, Aschner M. Tinkov AA, et al. Int J Mol Sci. 2021 Apr 28;22(9):4646. doi: 10.3390/ijms22094646. Int J Mol Sci. 2021. PMID: 33925013 Free PMC article. Review.
We provide, here, a brief review of pertinent discoveries related to Mn-induced neurotoxicity research from the last five years. Significant progress was achieved in understanding the role of Mn transporters, such as SLC39A14, SLC39A8, and SLC30A10, in the regulation of sy …
We provide, here, a brief review of pertinent discoveries related to Mn-induced neurotoxicity research from the last five years. Sign …
Manganese: Its Role in Disease and Health.
Erikson KM, Aschner M. Erikson KM, et al. Met Ions Life Sci. 2019 Jan 14;19:/books/9783110527872/9783110527872-016/9783110527872-016.xml. doi: 10.1515/9783110527872-016. Met Ions Life Sci. 2019. PMID: 30855111 Free article. Review.
Manganese is an essential dietary element that functions primarily as a coenzyme in several biological processes. ...The objective of this chapter is to address the biological importance of Mn (essentiality), routes of exposure, factors dictating Mn status, a brief discuss
Manganese is an essential dietary element that functions primarily as a coenzyme in several biological processes. ...The objective of
Manganese metabolism in humans.
Chen P, Bornhorst J, Aschner M. Chen P, et al. Front Biosci (Landmark Ed). 2018 Mar 1;23:1655-1679. doi: 10.2741/4665. Front Biosci (Landmark Ed). 2018. PMID: 29293455 Free article. Review.
Manganese (Mn) is an essential nutrient for intracellular activities; it functions as a cofactor for a variety of enzymes, including arginase, glutamine synthetase (GS), pyruvate carboxylase and Mn superoxide dismutase (Mn-SOD). ...In recent years, Mn has come to the foref
Manganese (Mn) is an essential nutrient for intracellular activities; it functions as a cofactor for a variety of enzymes, including
Role of Astrocytes in Manganese Neurotoxicity Revisited.
Ke T, Sidoryk-Wegrzynowicz M, Pajarillo E, Rizor A, Soares FAA, Lee E, Aschner M. Ke T, et al. Neurochem Res. 2019 Nov;44(11):2449-2459. doi: 10.1007/s11064-019-02881-7. Epub 2019 Sep 30. Neurochem Res. 2019. PMID: 31571097 Free PMC article. Review.
Manganese (Mn) overexposure is a public health concern due to its widespread industrial usage and the risk for environmental contamination. The clinical symptoms of Mn neurotoxicity, or manganism, share several pathological features of Parkinson's disease (PD). ...
Manganese (Mn) overexposure is a public health concern due to its widespread industrial usage and the risk for environmental contamin
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms.
Nyarko-Danquah I, Pajarillo E, Digman A, Soliman KFA, Aschner M, Lee E. Nyarko-Danquah I, et al. Molecules. 2020 Dec 12;25(24):5880. doi: 10.3390/molecules25245880. Molecules. 2020. PMID: 33322668 Free PMC article. Review.
Manganese (Mn) is an essential trace element, serving as a cofactor for several key enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and mitochondrial superoxide dismutase. ...The pathological symptoms of Mn-induced toxicity are well-known, but the
Manganese (Mn) is an essential trace element, serving as a cofactor for several key enzymes, such as glutamine synthetase, arginase,
Brain manganese and the balance between essential roles and neurotoxicity.
Balachandran RC, Mukhopadhyay S, McBride D, Veevers J, Harrison FE, Aschner M, Haynes EN, Bowman AB. Balachandran RC, et al. J Biol Chem. 2020 May 8;295(19):6312-6329. doi: 10.1074/jbc.REV119.009453. Epub 2020 Mar 18. J Biol Chem. 2020. PMID: 32188696 Free PMC article. Review.
Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. ...This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions
Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. ...This review
Critical Involvement of Glial Cells in Manganese Neurotoxicity.
Soto-Verdugo J, Ortega A. Soto-Verdugo J, et al. Biomed Res Int. 2021 Oct 6;2021:1596185. doi: 10.1155/2021/1596185. eCollection 2021. Biomed Res Int. 2021. PMID: 34660781 Free PMC article. Review.
Manganese is an essential trace element that in high doses exerts neurotoxic effects. ...This review highlights the pivotal role that glial cells have in manganese-induced neurotoxicity as well as the most sounding mechanisms involved in the developmen
Manganese is an essential trace element that in high doses exerts neurotoxic effects. ...This review highlights the pivotal ro
Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14.
Mukhopadhyay S. Mukhopadhyay S. Neurotoxicology. 2018 Jan;64:278-283. doi: 10.1016/j.neuro.2017.07.030. Epub 2017 Aug 5. Neurotoxicology. 2018. PMID: 28789954 Free PMC article. Review.
Over the last few years, two rare, familial diseases that lead to the onset of manganese (Mn)-induced neurotoxicity have been discovered. Loss-of-function mutations in SLC30A10, a Mn efflux transporter, or SLC39A14, a Mn influx transporter, increase Mn levels in blo …
Over the last few years, two rare, familial diseases that lead to the onset of manganese (Mn)-induced neurotoxicity have been …
2,380 results