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Year Number of Results
1893 1
1897 1
1916 1
1923 2
1929 1
1936 1
1944 1
1945 37
1946 211
1947 138
1948 168
1949 118
1950 159
1951 208
1952 220
1953 212
1954 232
1955 269
1956 218
1957 190
1958 223
1959 206
1960 229
1961 262
1962 337
1963 590
1964 786
1965 591
1966 617
1967 774
1968 851
1969 850
1970 835
1971 936
1972 864
1973 892
1974 880
1975 816
1976 735
1977 757
1978 711
1979 785
1980 789
1981 894
1982 927
1983 1033
1984 1288
1985 1565
1986 1869
1987 2006
1988 1904
1989 2324
1990 2304
1991 2282
1992 2299
1993 2271
1994 2104
1995 2338
1996 2212
1997 2312
1998 2339
1999 2539
2000 2554
2001 2699
2002 2754
2003 2904
2004 2992
2005 3347
2006 3717
2007 3813
2008 3940
2009 3962
2010 4210
2011 4594
2012 4787
2013 4791
2014 4940
2015 4969
2016 4792
2017 4931
2018 5056
2019 5182
2020 6606
2021 5911
2022 5206
2023 4003
2024 1596

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146,974 results

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Page 1
Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein.
Lindner T, Loktev A, Altmann A, Giesel F, Kratochwil C, Debus J, Jäger D, Mier W, Haberkorn U. Lindner T, et al. J Nucl Med. 2018 Sep;59(9):1415-1422. doi: 10.2967/jnumed.118.210443. Epub 2018 Apr 6. J Nucl Med. 2018. PMID: 29626119 Free article.
In this investigation, FAP inhibitors (FAPIs) were modified and optimized for use as theranostic tracers. Methods: FAPIs based on a quinoline structure were synthesized and characterized with respect to binding, internalization, and efflux in cells expressing human and mur …
In this investigation, FAP inhibitors (FAPIs) were modified and optimized for use as theranostic tracers. Methods: FAPIs based on a quino …
Quinoline-based antifungals.
Musiol R, Serda M, Hensel-Bielowka S, Polanski J. Musiol R, et al. Curr Med Chem. 2010;17(18):1960-73. doi: 10.2174/092986710791163966. Curr Med Chem. 2010. PMID: 20377510 Review.
Structural similarities between quinoline based antifungals and allylamines or homoallylamines, e.g. terbinafine is another interesting fact. ...We have discussed new trends in the design of quinolines with antifungal properties, their possible targets and the struc …
Structural similarities between quinoline based antifungals and allylamines or homoallylamines, e.g. terbinafine is another interesti …
Quinoline and quinolone dimers and their biological activities: An overview.
Chu XM, Wang C, Liu W, Liang LL, Gong KK, Zhao CY, Sun KL. Chu XM, et al. Eur J Med Chem. 2019 Jan 1;161:101-117. doi: 10.1016/j.ejmech.2018.10.035. Epub 2018 Oct 16. Eur J Med Chem. 2019. PMID: 30343191 Review.
Quinoline and quinolone motifs which act as structural subunits of more complex natural products are ubiquitous in nature, and they are useful pharmacophores which play a pivotal role in drug development. ...
Quinoline and quinolone motifs which act as structural subunits of more complex natural products are ubiquitous in nature, and they a …
Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets.
Lauria A, La Monica G, Bono A, Martorana A. Lauria A, et al. Eur J Med Chem. 2021 Aug 5;220:113555. doi: 10.1016/j.ejmech.2021.113555. Epub 2021 May 24. Eur J Med Chem. 2021. PMID: 34052677 Review.
Quinoline is one of the most important and versatile nitrogen heterocycles embodied in several biologically active molecules. ...In this light, a special focus is given to the quinoline compounds, acting with classical/well-known mechanisms of action (DNA intercalat …
Quinoline is one of the most important and versatile nitrogen heterocycles embodied in several biologically active molecules. ...In t …
Identification of quinoline-chalcones and heterocyclic chalcone-appended quinolines as broad-spectrum pharmacological agents.
Atukuri D, S V, R S, L V, R P, M M R. Atukuri D, et al. Bioorg Chem. 2020 Dec;105:104419. doi: 10.1016/j.bioorg.2020.104419. Epub 2020 Oct 22. Bioorg Chem. 2020. PMID: 33142228 Review.
Quinoline derivatives have been reported to possess enticing pharmacological properties. In particular, quinoline-chalcones are identified as promising scaffolds for drug discovery. ...
Quinoline derivatives have been reported to possess enticing pharmacological properties. In particular, quinoline-chalcones ar …
Quinoline: a promising antitubercular target.
Keri RS, Patil SA. Keri RS, et al. Biomed Pharmacother. 2014 Oct;68(8):1161-75. doi: 10.1016/j.biopha.2014.10.007. Epub 2014 Oct 29. Biomed Pharmacother. 2014. PMID: 25458785 Review.
Certain, quinoline-based compounds, also show effective anti-TB activity. This broad spectrum of biological and biochemical activities has been further facilitated by the synthetic versatility of quinoline, which allows the generation of a large number of structural …
Certain, quinoline-based compounds, also show effective anti-TB activity. This broad spectrum of biological and biochemical activitie …
Biologically active quinoline and quinazoline alkaloids part I.
Shang XF, Morris-Natschke SL, Liu YQ, Guo X, Xu XS, Goto M, Li JC, Yang GZ, Lee KH. Shang XF, et al. Med Res Rev. 2018 May;38(3):775-828. doi: 10.1002/med.21466. Epub 2017 Sep 13. Med Res Rev. 2018. PMID: 28902434 Free PMC article. Review.
Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic compounds, have attracted tremendous attention from researchers worldwide since the 19th century. ...This survey should provide new clues or possibilities for the discovery of new and better …
Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic compounds, have attracted tremendous attention fro …
Biologically active quinoline and quinazoline alkaloids part II.
Shang XF, Morris-Natschke SL, Yang GZ, Liu YQ, Guo X, Xu XS, Goto M, Li JC, Zhang JY, Lee KH. Shang XF, et al. Med Res Rev. 2018 Sep;38(5):1614-1660. doi: 10.1002/med.21492. Epub 2018 Feb 27. Med Res Rev. 2018. PMID: 29485730 Free PMC article. Review.
To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes …
To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinaz …
Quinoline-based antimalarial hybrid compounds.
Vandekerckhove S, D'hooghe M. Vandekerckhove S, et al. Bioorg Med Chem. 2015 Aug 15;23(16):5098-119. doi: 10.1016/j.bmc.2014.12.018. Epub 2014 Dec 19. Bioorg Med Chem. 2015. PMID: 25593097 Review.
Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing history as potent antimalarial agents. ...A strategy that has attracted considerable attention in current medicinal chemistry is based on the conjugation of two biologically active molecu …
Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing history as potent antimalarial agents. ...A str …
Enzymatic approaches to site-selective oxidation of quinoline and derivatives.
Wang Z, Zhao L, Mou X, Chen Y. Wang Z, et al. Org Biomol Chem. 2022 Mar 30;20(13):2580-2600. doi: 10.1039/d2ob00200k. Org Biomol Chem. 2022. PMID: 35290426 Review.
Enzyme-mediated oxidation has been a green and efficient strategy for preparation of derivative chemicals from quinoline and its structural analogues. Herein, we report the progress made to date in enzymatic methods to oxidation of the pyridine moieties of quinoline …
Enzyme-mediated oxidation has been a green and efficient strategy for preparation of derivative chemicals from quinoline and its stru …
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