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Year Number of Results
1986 2
1987 6
1988 20
1989 47
1990 81
1991 101
1992 85
1993 92
1994 106
1995 156
1996 144
1997 156
1998 186
1999 204
2000 209
2001 313
2002 319
2003 375
2004 381
2005 481
2006 472
2007 499
2008 645
2009 572
2010 621
2011 629
2012 623
2013 649
2014 663
2015 652
2016 629
2017 564
2018 541
2019 529
2020 572
2021 459
2022 437
2023 406
2024 157

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12,452 results

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Page 1
Simvastatin induced ferroptosis for triple-negative breast cancer therapy.
Yao X, Xie R, Cao Y, Tang J, Men Y, Peng H, Yang W. Yao X, et al. J Nanobiotechnology. 2021 Oct 9;19(1):311. doi: 10.1186/s12951-021-01058-1. J Nanobiotechnology. 2021. PMID: 34627266 Free PMC article.
Herein, a novel ferroptosis nanomedicine was prepared by loading simvastatin (SIM), a ferroptosis drug, into zwitterionic polymer coated magnetic nanoparticles (Fe(3)O(4)@PCBMA) to improve the therapeutic effect of TNBC. ...
Herein, a novel ferroptosis nanomedicine was prepared by loading simvastatin (SIM), a ferroptosis drug, into zwitterionic polymer coa …
Simvastatin: a review.
Pedersen TR, Tobert JA. Pedersen TR, et al. Expert Opin Pharmacother. 2004 Dec;5(12):2583-96. doi: 10.1517/14656566.5.12.2583. Expert Opin Pharmacother. 2004. PMID: 15571475 Review.
Simvastatin is a long-established hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, first introduced in 1988. ...Simvastatin has recently become available in many countries as a combination product with the cholesterol absorption inhibitor, ezetimibe. …
Simvastatin is a long-established hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, first introduced in 1988. ...Si …
The potential use of simvastatin for cancer treatment: A review.
Duarte JA, de Barros ALB, Leite EA. Duarte JA, et al. Biomed Pharmacother. 2021 Sep;141:111858. doi: 10.1016/j.biopha.2021.111858. Epub 2021 Jul 10. Biomed Pharmacother. 2021. PMID: 34323700 Free article. Review.
Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting anticancer activities. Among them, especially simvastatin may influence the proliferation, migration, and survival of cancer cells. ...In this review, we present an overview of the most i …
Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting anticancer activities. Among them, especially simva …
Synthetic Approaches Towards Antihypercholesterolemic Drug Simvastatin.
Fattah TA, Saeed A, Shehzadi SA. Fattah TA, et al. Curr Org Synth. 2019;16(5):652-670. doi: 10.2174/1570179416666190725095951. Curr Org Synth. 2019. PMID: 31984887 Review.
This review article aims to provide an overview of several chemical and biological methods utilized for the production of simvastatin in high yields and purity. Many robust and scalable methods have been described using lovastatin (2: Mevinolin) as a starting material, pro …
This review article aims to provide an overview of several chemical and biological methods utilized for the production of simvastatin …
Simvastatin: present and future perspectives.
Robinson JG. Robinson JG. Expert Opin Pharmacother. 2007 Sep;8(13):2159-27. doi: 10.1517/14656566.8.13.2159. Expert Opin Pharmacother. 2007. PMID: 17714068 Review.
Simvastatin is lipophilic statin with a short half-life that is primarily metabolized by CYP450 3A4. At doses of 5 - 80 mg, simvastatin lowers LDL cholesterol by 25 - 50%. Simvastatin has been shown to reduce the risk of cardiovascular disease by 35% and over …
Simvastatin is lipophilic statin with a short half-life that is primarily metabolized by CYP450 3A4. At doses of 5 - 80 mg, simvas …
PAI-1 inhibition by simvastatin as a positive adjuvant in cell therapy.
de Faria CA, Zanette DL, Silva WA Jr, Ribeiro-Paes JT. de Faria CA, et al. Mol Biol Rep. 2019 Feb;46(1):1511-1517. doi: 10.1007/s11033-018-4562-4. Epub 2019 Jan 5. Mol Biol Rep. 2019. PMID: 30612281 Review.
Thus, simvastatin-induced reduction of PAI-1 levels has a therapeutic potential by modulating the main processes involved in the creation of an inhospitable environment during the process of injury (fibrosis and cell migration). In this way, simvastatin modulates pr …
Thus, simvastatin-induced reduction of PAI-1 levels has a therapeutic potential by modulating the main processes involved in the crea …
Ezetimibe/Simvastatin: a review of its use in the management of hypercholesterolemia.
Murdoch D, Scott LJ. Murdoch D, et al. Am J Cardiovasc Drugs. 2004;4(6):405-22. doi: 10.2165/00129784-200404060-00009. Am J Cardiovasc Drugs. 2004. PMID: 15554726 Review.
Ezetimibe/simvastatin (Inegy, Vytorin) therapy combines two lipid-lowering compounds with complementary mechanisms of action, thereby blocking the two sources of plasma cholesterol and improving lipid profiles. ...Furthermore, ezetimibe/simvastatin is formulated wit …
Ezetimibe/simvastatin (Inegy, Vytorin) therapy combines two lipid-lowering compounds with complementary mechanisms of action, thereby …
Simvastatin ameliorates testosterone-induced prostatic hyperplasia in rats via modulating IGF-1/PI3K/AKT/FOXO signaling.
El-Shafei NH, Zaafan MA, Kandil EA, Sayed RH. El-Shafei NH, et al. Eur J Pharmacol. 2023 Jul 5;950:175762. doi: 10.1016/j.ejphar.2023.175762. Epub 2023 May 8. Eur J Pharmacol. 2023. PMID: 37164119
Beyond statins' common uses, they also have anti-inflammatory, antioxidant, and anti-tumor effects. This study aims to determine simvastatin's beneficial effect on testosterone-induced BPH. Rats were randomly allocated into four groups, 9 rats each. The control grou …
Beyond statins' common uses, they also have anti-inflammatory, antioxidant, and anti-tumor effects. This study aims to determine simvasta …
Ezetimibe plus simvastatin for the treatment of hypercholesterolemia.
Gryn SE, Hegele RA. Gryn SE, et al. Expert Opin Pharmacother. 2015 Jun;16(8):1255-62. doi: 10.1517/14656566.2015.1041504. Epub 2015 Apr 28. Expert Opin Pharmacother. 2015. PMID: 25920750 Review.
INTRODUCTION: Cardiovascular disease is a major cause of death, and hypercholesterolemia is a major risk factor. Statins, with simvastatin among the most widely used, have ample evidence demonstrating prevention of cardiovascular events and mortality. ...EXPERT OPINION: Ez …
INTRODUCTION: Cardiovascular disease is a major cause of death, and hypercholesterolemia is a major risk factor. Statins, with simvastati …
Simvastatin.
Cejka J, Kratochvíl B, Císarová I, Jegorov A. Cejka J, et al. Acta Crystallogr C. 2003 Aug;59(Pt 8):o428-30. doi: 10.1107/s0108270103012514. Epub 2003 Jul 12. Acta Crystallogr C. 2003. PMID: 12909768
Simvastatin, or (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate, C(25)H(38)O(5), is almost isostructural with lovastatin, and the general conformational feature …
Simvastatin, or (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hex …
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