Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 2
1961 1
1979 1
1988 1
1997 1
1999 2
2000 3
2001 4
2002 2
2003 3
2004 5
2005 6
2006 7
2007 12
2008 8
2009 8
2010 16
2011 19
2012 26
2013 23
2014 26
2015 28
2016 48
2017 67
2018 68
2019 56
2020 91
2021 87
2022 89
2023 78
2024 24

Text availability

Article attribute

Article type

Publication date

Search Results

199 results

Results by year

Filters applied: from 2018/1/1 - 2020/12/31. Clear all
Page 1
Impact of neoadjuvant chemotherapy and stereotactic body radiation therapy (SBRT) on R0 resection rate for borderline resectable and locally advanced pancreatic cancer.
Zakem SJ, Mueller AC, Meguid C, Torphy RJ, Holt DE, Schefter T, Messersmith WA, McCarter MD, Del Chiaro M, Schulick RD, Goodman KA. Zakem SJ, et al. HPB (Oxford). 2021 Jul;23(7):1072-1083. doi: 10.1016/j.hpb.2020.11.004. Epub 2020 Dec 1. HPB (Oxford). 2021. PMID: 33277184 Free article.
BACKGROUND: The role of neoadjuvant stereotactic body radiation therapy (SBRT) in patients with borderline resectable pancreas cancer (BRPC) and locally advanced pancreas cancer (LAPC) remains controversial. ...
BACKGROUND: The role of neoadjuvant stereotactic body radiation therapy (SBRT) in patients with borderline resectable pancreas …
Maximizing Tumor Control and Limiting Complications With Stereotactic Body Radiation Therapy for Pancreatic Cancer.
Mahadevan A, Moningi S, Grimm J, Li XA, Forster KM, Palta M, Prior P, Goodman KA, Narang A, Heron DE, Lo SS, Urbanic J, Herman JM. Mahadevan A, et al. Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):206-216. doi: 10.1016/j.ijrobp.2020.11.017. Epub 2020 Dec 24. Int J Radiat Oncol Biol Phys. 2021. PMID: 33358561 Review.
PURPOSE: Stereotactic body radiation therapy (SBRT) and stereotactic ablative body radiation therapy is being increasingly used for pancreatic cancer (PCa), particularly in patients with locally advanced and borderline resectable disease. ...
PURPOSE: Stereotactic body radiation therapy (SBRT) and stereotactic ablative body radiation therapy is being increasingly use …
Toxicity of L19-Interleukin 2 Combined with Stereotactic Body Radiation Therapy: A Phase 1 Study.
Van Limbergen EJ, Hoeben A, Lieverse RIY, Houben R, Overhof C, Postma A, Zindler J, Verhelst F, Dubois LJ, De Ruysscher D, Troost EGC, Lambin P. Van Limbergen EJ, et al. Int J Radiat Oncol Biol Phys. 2021 Apr 1;109(5):1421-1430. doi: 10.1016/j.ijrobp.2020.11.053. Epub 2020 Dec 4. Int J Radiat Oncol Biol Phys. 2021. PMID: 33285270 Free article. Clinical Trial.
In this study, the safety and tolerability of L19-IL2 after stereotactic body radiation therapy (SBRT) was assessed. METHODS AND MATERIALS: Patients with oligometastatic solid tumors received radical SBRT to all visible metastases. ...
In this study, the safety and tolerability of L19-IL2 after stereotactic body radiation therapy (SBRT) was assessed. METHODS AND MATE …
An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy.
Zhang J, Wang C, Sheng Y, Palta M, Czito B, Willett C, Zhang J, Jensen PJ, Yin FF, Wu Q, Ge Y, Wu QJ. Zhang J, et al. Int J Radiat Oncol Biol Phys. 2021 Mar 15;109(4):1076-1085. doi: 10.1016/j.ijrobp.2020.10.019. Epub 2020 Oct 25. Int J Radiat Oncol Biol Phys. 2021. PMID: 33115686 Free PMC article.
PURPOSE: Pancreas stereotactic body radiation therapy (SBRT) treatment planning requires planners to make sequential, time-consuming interactions with the treatment planning system to reach the optimal dose distribution. ...CONCLUSIONS: We developed a planning bot t …
PURPOSE: Pancreas stereotactic body radiation therapy (SBRT) treatment planning requires planners to make sequential, time-con …
Evaluation of Clinician Contouring for Pancreatic Stereotactic Ablative Radiotherapy During a Contouring Workshop Organised by the Royal College of Radiologists.
Slevin F, Beasley M, Speight R, Lilley J, Murray L, Hawkins M, Radhakrishna G, Henry A. Slevin F, et al. Clin Oncol (R Coll Radiol). 2021 Mar;33(3):e196-e197. doi: 10.1016/j.clon.2020.10.014. Epub 2020 Oct 29. Clin Oncol (R Coll Radiol). 2021. PMID: 33129654 Free article. No abstract available.
Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided Radiation Therapy With On-Table Adaptive Replanning and Elective Nodal Irradiation for Inoperable Pancreas Cancer.
Chuong MD, Bryant J, Mittauer KE, Hall M, Kotecha R, Alvarez D, Romaguera T, Rubens M, Adamson S, Godley A, Mishra V, Luciani G, Gutierrez AN. Chuong MD, et al. Pract Radiat Oncol. 2021 Mar-Apr;11(2):134-147. doi: 10.1016/j.prro.2020.09.005. Epub 2020 Sep 16. Pract Radiat Oncol. 2021. PMID: 32947042 Free article.
PURPOSE: Radiation therapy dose escalation using stereotactic body radiation therapy may significantly improve both local control (LC) and overall survival (OS) for patients with inoperable pancreas cancer. ...METHODS AND MATERIALS: We performed a single institution …
PURPOSE: Radiation therapy dose escalation using stereotactic body radiation therapy may significantly improve both local control (LC …
A Pilot Study of Galunisertib plus Stereotactic Body Radiotherapy in Patients with Advanced Hepatocellular Carcinoma.
Reiss KA, Wattenberg MM, Damjanov N, Prechtel Dunphy E, Jacobs-Small M, Lubas MJ, Robinson J, Dicicco L, Garcia-Marcano L, Giannone MA, Karasic TB, Furth EE, Carpenter EL, Wojcieszynski AP, Vonderheide RH, Beatty GL, Ben-Josef E. Reiss KA, et al. Mol Cancer Ther. 2021 Feb;20(2):389-397. doi: 10.1158/1535-7163.MCT-20-0632. Epub 2020 Dec 2. Mol Cancer Ther. 2021. PMID: 33268571 Free PMC article.
Here, we combined galunisertib, an oral TGFbeta inhibitor, with stereotactic body radiotherapy (SBRT) in patients with advanced hepatocellular carcinoma (HCC) and assessed safety, efficacy, and immunologic correlatives. ...
Here, we combined galunisertib, an oral TGFbeta inhibitor, with stereotactic body radiotherapy (SBRT) in patients with advance …
A phase II study of stereotactic radiotherapy after FOLFIRINOX for locally advanced pancreatic cancer (LAPC-1 trial): Long-term outcome.
Teriaca MA, Loi M, Suker M, Eskens FALM, van Eijck CHJ, Nuyttens JJ. Teriaca MA, et al. Radiother Oncol. 2021 Feb;155:232-236. doi: 10.1016/j.radonc.2020.11.006. Epub 2020 Nov 17. Radiother Oncol. 2021. PMID: 33217500 Clinical Trial.
PURPOSE: To report the long-term outcome of a multicenter phase II study with FOLFIRINOX followed by stereotactic body radiotherapy (LAPC-1 trial) in patients with locally advanced pancreatic cancer (LAPC). ...If no disease progression was found after chemoth …
PURPOSE: To report the long-term outcome of a multicenter phase II study with FOLFIRINOX followed by stereotactic body radiotherap …
SPARC, a phase-I trial of pre-operative, margin intensified, stereotactic body radiation therapy for pancreatic cancer.
Holyoake DLP, Robinson M, Silva M, Grose D, McIntosh D, Sebag-Montefiore D, Radhakrishna G, Mukherjee S, Hawkins MA. Holyoake DLP, et al. Radiother Oncol. 2021 Feb;155:278-284. doi: 10.1016/j.radonc.2020.11.007. Epub 2020 Nov 18. Radiother Oncol. 2021. PMID: 33217498 Free article. Clinical Trial.
BACKGROUND AND PURPOSE: Following resection of pancreatic cancer, risk of positive margins and local recurrence remain high, especially for borderline-resectable pancreatic cancer (BRPC). We aimed to establish the maximum tolerated dose of a margin-intensified five- …
BACKGROUND AND PURPOSE: Following resection of pancreatic cancer, risk of positive margins and local recurrence remain high, especial …
Narrow-Margin Hepatectomy Resulted in Higher Recurrence and Lower Overall Survival for R0 Resection Hepatocellular Carcinoma.
Liu L, Shui Y, Yu Q, Guo Y, Zhang L, Zhou X, Yu R, Lou J, Wei S, Wei Q. Liu L, et al. Front Oncol. 2021 Jan 21;10:610636. doi: 10.3389/fonc.2020.610636. eCollection 2020. Front Oncol. 2021. PMID: 33552983 Free PMC article.
An additional cohort of nine cases with positive margin plus post-operative stereotactic body radiotherapy (SBRT) was also analyzed for the recurrence pattern. ...These patients may benefit from adjuvant local treatment, such as radiotherapy....
An additional cohort of nine cases with positive margin plus post-operative stereotactic body radiotherapy (SBRT) was also ana …
Efficacy and feasibility of re-irradiation using carbon ions for pancreatic cancer that recurs after carbon-ion radiotherapy.
Hagiwara Y, Yamada S, Isozaki Y, Takiyama H, Shinoto M, Kawashiro S, Bhattacharyya T, Nemoto K, Tsuji H. Hagiwara Y, et al. Clin Transl Radiat Oncol. 2020 Nov 6;26:24-29. doi: 10.1016/j.ctro.2020.10.007. eCollection 2021 Jan. Clin Transl Radiat Oncol. 2020. PMID: 33294643 Free PMC article.
BACKGROUND AND PURPOSE: Patients who receive carbon-ion radiotherapy (C-ion RT) for primary pancreatic cancer may experience locoregional recurrence; however, the treatment options for such patients are limited. ...This is the first study to examine re-irradiation u …
BACKGROUND AND PURPOSE: Patients who receive carbon-ion radiotherapy (C-ion RT) for primary pancreatic cancer may experience l …
First report on the feasibility of a permanently implantable uni-directional planar low dose rate brachytherapy sheet for patients with resectable or borderline resectable pancreatic cancer.
Dault JB, Todor D, Kaplan BJ, Myers JL, Fields EC. Dault JB, et al. Brachytherapy. 2021 Jan-Feb;20(1):207-217. doi: 10.1016/j.brachy.2020.08.010. Epub 2020 Sep 23. Brachytherapy. 2021. PMID: 32978081
BACKGROUND: Margin negative resection in pancreatic cancer remains the only curative option but is challenging, especially with the retroperitoneal margin. ...A dosimetric comparison of the LDR sheet with hypothetical stereotactic body radiotherapy (SBRT) boo …
BACKGROUND: Margin negative resection in pancreatic cancer remains the only curative option but is challenging, especially with the r …
Transarterial fiducial marker implantation for CyberKnife radiotherapy to treat pancreatic cancer: an experience with 14 cases.
Imaizumi A, Araki T, Okada H, Sasaki Y, Komiyama T, Suzuki T, Takahashi H, Onishi H. Imaizumi A, et al. Jpn J Radiol. 2021 Jan;39(1):84-92. doi: 10.1007/s11604-020-01040-1. Epub 2020 Sep 11. Jpn J Radiol. 2021. PMID: 32918250 Free PMC article.
PURPOSE: The purpose of this study was to evaluate the safety and feasibility of transarterial fiducial marker implantation for CyberKnife radiotherapy to treat locally advanced pancreatic cancer. MATERIALS AND METHODS: Fifteen pancreatic cancer patients were …
PURPOSE: The purpose of this study was to evaluate the safety and feasibility of transarterial fiducial marker implantation for CyberKnife …
ESTRO ACROP guidelines for target volume definition in pancreatic cancer.
Brunner TB, Haustermans K, Huguet F, Morganti AG, Mukherjee S, Belka C, Krempien R, Hawkins MA, Valentini V, Roeder F. Brunner TB, et al. Radiother Oncol. 2021 Jan;154:60-69. doi: 10.1016/j.radonc.2020.07.052. Epub 2020 Aug 28. Radiother Oncol. 2021. PMID: 32861703
Despite of the predominant role of chemotherapy and surgery in pancreatic ductal adenocarcinoma (PDAC), radiotherapy (RT) still has a place in multimodal management of this disease where local tumour sequelae are fatal in about 40% of the patients. RT (chemoradiothe …
Despite of the predominant role of chemotherapy and surgery in pancreatic ductal adenocarcinoma (PDAC), radiotherapy (RT) stil …
Hypofractionated Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost and Simultaneous Integrated Protection in Pancreatic Ductal Adenocarcinoma.
Simoni N, Micera R, Paiella S, Guariglia S, Zivelonghi E, Malleo G, Rossi G, Addari L, Giuliani T, Pollini T, Cavedon C, Salvia R, Milella M, Bassi C, Mazzarotto R. Simoni N, et al. Clin Oncol (R Coll Radiol). 2021 Jan;33(1):e31-e38. doi: 10.1016/j.clon.2020.06.019. Epub 2020 Jul 15. Clin Oncol (R Coll Radiol). 2021. PMID: 32682686
AIMS: To evaluate the safety and feasibility of stereotactic body radiation therapy (SBRT) with simultaneous integrated boost (SIB) and simultaneous integrated protection (SIP) in borderline resectable and locally advanced pancreatic ductal adenocarcinoma. ...CONCLU …
AIMS: To evaluate the safety and feasibility of stereotactic body radiation therapy (SBRT) with simultaneous integrated boost (SIB) a …
Personalized designs of adjuvant radiotherapy for pancreatic cancer based on molecular profiles.
Zhu X, Cao Y, Ju X, Zhao X, Jiang L, Ye Y, Shen Y, Cao F, Qing S, Zhang H. Zhu X, et al. Cancer Sci. 2021 Jan;112(1):287-295. doi: 10.1111/cas.14486. Epub 2020 Nov 7. Cancer Sci. 2021. PMID: 32418280 Free PMC article.
This study aims to identify postoperative recurrence patterns of pancreatic cancer with different molecular profiles, which provides evidence for personalized target volumes of adjuvant radiotherapy. Patients with pathologically confirmed resectable pancreatic …
This study aims to identify postoperative recurrence patterns of pancreatic cancer with different molecular profiles, which provides …
Dosimetric Feasibility Study of Dose Escalated Stereotactic Body Radiation Therapy (SBRT) in Locally Advanced Pancreatic Cancer (LAPC) Patients: It Is Time to Raise the Bar.
Mazzarotto R, Simoni N, Guariglia S, Rossi G, Micera R, De Robertis R, Pierelli A, Zivelonghi E, Malleo G, Paiella S, Salvia R, Cavedon C, Milella M, Bassi C. Mazzarotto R, et al. Front Oncol. 2020 Dec 17;10:600940. doi: 10.3389/fonc.2020.600940. eCollection 2020. Front Oncol. 2020. PMID: 33392093 Free PMC article.
BACKGROUND AND OBJECTIVE: To assess the dosimetric feasibility of a stereotactic body radiotherapy (SBRT) dose escalated protocol, with a simultaneous integrated boost (SIB) and a simultaneous integrated protection (SIP) approach, in patients with locally advanced …
BACKGROUND AND OBJECTIVE: To assess the dosimetric feasibility of a stereotactic body radiotherapy (SBRT) dose escalated proto …
Failure patterns and outcomes of dose escalation of stereotactic body radiotherapy for locally advanced pancreatic cancer: a multicenter cohort study.
Zhu X, Cao Y, Su T, Zhu X, Ju X, Zhao X, Jiang L, Ye Y, Cao F, Qing S, Zhang H. Zhu X, et al. Ther Adv Med Oncol. 2020 Dec 14;12:1758835920977155. doi: 10.1177/1758835920977155. eCollection 2020. Ther Adv Med Oncol. 2020. PMID: 33403017 Free PMC article.
OBJECTIVE: This study aims to compare recurrence patterns and outcomes of biologically effective dose (BED(10), alpha/beta = 10) of 60-70 Gy with those of a BED(10) >70 Gy for locally advanced pancreatic cancer (LAPC). METHODS: Patients from three centers with a biopsy …
OBJECTIVE: This study aims to compare recurrence patterns and outcomes of biologically effective dose (BED(10), alpha/beta = 10) of 60-70 Gy …
The gimbaled-head radiotherapy system: Rise and downfall of a dedicated system for dynamic tumor tracking with real-time monitoring and dynamic WaveArc.
Hiraoka M, Mizowaki T, Matsuo Y, Nakamura M, Verellen D. Hiraoka M, et al. Radiother Oncol. 2020 Dec;153:311-318. doi: 10.1016/j.radonc.2020.07.002. Epub 2020 Jul 11. Radiother Oncol. 2020. PMID: 32659250 Free article. Review.
The unique structures with multi-image guidance functions initiated 2 new treatment modalities. One is dynamic tumor tracking radiotherapy with real time monitoring (DTTRM), which enables 4-D radiotherapy without prolongation of radiotherapy treatment time. T …
The unique structures with multi-image guidance functions initiated 2 new treatment modalities. One is dynamic tumor tracking radiotherap …
Radiation therapy for patients with locally advanced pancreatic cancer: Evolving techniques and treatment strategies.
Abi Jaoude J, Kouzy R, Nguyen ND, Lin D, Noticewala SS, Ludmir EB, Taniguchi CM. Abi Jaoude J, et al. Curr Probl Cancer. 2020 Dec;44(6):100607. doi: 10.1016/j.currproblcancer.2020.100607. Epub 2020 May 21. Curr Probl Cancer. 2020. PMID: 32471736 Review.
Despite ongoing efforts, patients with locally advanced pancreatic cancer (LAPC) continue to have a dismal prognosis. Such tumors are unresectable, and optimal treatment with chemotherapy and/or radiation therapy is still not established. ...Because of the high doses deliv …
Despite ongoing efforts, patients with locally advanced pancreatic cancer (LAPC) continue to have a dismal prognosis. Such tumors are …
Stereotactic body radiation therapy mitigates radiation induced lymphopenia in early stage non-small cell lung cancer.
McLaughlin MF, Alam M, Smith L, Ryckman J, Lin C, Baine MJ. McLaughlin MF, et al. PLoS One. 2020 Nov 30;15(11):e0241505. doi: 10.1371/journal.pone.0241505. eCollection 2020. PLoS One. 2020. PMID: 33253196 Free PMC article.
INTRODUCTION: Radiation-induced lymphopenia (RIL) occurs during treatment with conventional radiation in multiple organ sites. Development of RIL portends poor prognosis. Stereotactic body radiation therapy (SBRT) spares RIL in pancreatic cancer, but has not been ex …
INTRODUCTION: Radiation-induced lymphopenia (RIL) occurs during treatment with conventional radiation in multiple organ sites. Development o …
Chemotherapy-based split stereotactic body radiation therapy for borderline resectable and locally advanced pancreatic cancer: study protocol of a prospective, single-arm phase II trial.
Zheng R, Wang C, Huang X, Lin Q, Huang D, Li XB, Huang H, Xu B. Zheng R, et al. BMJ Open. 2020 Nov 5;10(11):e039900. doi: 10.1136/bmjopen-2020-039900. BMJ Open. 2020. PMID: 33154057 Free PMC article.
INTRODUCTION: The question of how to administer adequate chemotherapy to synchronise stereotactic body radiation therapy (SBRT) treatment strategy to maximise the benefits of neoadjuvant therapy for the improved prognosis of patients with borderline resectable (BRPC) and l …
INTRODUCTION: The question of how to administer adequate chemotherapy to synchronise stereotactic body radiation therapy (SBRT) treat …
Automated treatment planning as a dose escalation strategy for stereotactic radiation therapy in pancreatic cancer.
Cilla S, Ianiro A, Romano C, Deodato F, Macchia G, Viola P, Buwenge M, Cammelli S, Pierro A, Valentini V, Morganti AG. Cilla S, et al. J Appl Clin Med Phys. 2020 Nov;21(11):48-57. doi: 10.1002/acm2.13025. Epub 2020 Oct 16. J Appl Clin Med Phys. 2020. PMID: 33063456 Free PMC article. Clinical Trial.
PURPOSE: To assess the feasibility of automated stereotactic volumetric modulated arc therapy (SBRT-VMAT) planning using a simultaneous integrated boost (SIB) approach as a dose escalation strategy for SBRT in pancreatic cancer. METHODS: Twelve patients with panc …
PURPOSE: To assess the feasibility of automated stereotactic volumetric modulated arc therapy (SBRT-VMAT) planning using a simultaneo …
Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1).
Arcelli A, Buwenge M, Macchia G, Bertini F, Guido A, Deodato F, Cilla S, Scotti V, Rosetto ME, Djan I, Parisi S, Mattiucci GC, Cellini F, Fiore M, Bonomo P, Belgioia L, Niespolo RM, Gabriele P, Di Marco M, Simoni N, Mazzarotto R, Morganti AG; AIRO (Italian Association of Radiation Oncology and Clinical Oncology) Gastrointestinal Study Group. Arcelli A, et al. Cancer Med. 2020 Nov;9(21):7879-7887. doi: 10.1002/cam4.3330. Epub 2020 Sep 10. Cancer Med. 2020. PMID: 32910549 Free PMC article.
Conventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in locally advanced pancreatic cancer (LAPC) while stereotactic body radiotherapy (SBRT) is an emerging treatment in this setting. ...
Conventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in locally advanced pancreatic …
Intensified systemic therapy and stereotactic ablative radiotherapy dose for patients with unresectable pancreatic adenocarcinoma.
Toesca DAS, Ahmed F, Kashyap M, Baclay JRM, von Eyben R, Pollom EL, Koong AC, Chang DT. Toesca DAS, et al. Radiother Oncol. 2020 Nov;152:63-69. doi: 10.1016/j.radonc.2020.07.053. Epub 2020 Aug 5. Radiother Oncol. 2020. PMID: 32763253
PURPOSE: We aimed to report the long-term impact of modern chemotherapy and SABR dose regimens on oncologic outcomes of unresectable pancreatic adenocarcinoma (PA). MATERIALS AND METHODS: We reviewed the treatment characteristics and outcomes of all patients who received m …
PURPOSE: We aimed to report the long-term impact of modern chemotherapy and SABR dose regimens on oncologic outcomes of unresectable panc …
Evaluation of a Novel Absorbable Radiopaque Hydrogel in Patients Undergoing Image Guided Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma.
Rao AD, Shin EJ, Meyer J, Thompson EL, Fu W, Hu C, Fishman EK, Weiss M, Wolfgang C, Burkhart R, He J, Kerdsirichairat T, Herman JM, Ding K, Narang A. Rao AD, et al. Pract Radiat Oncol. 2020 Nov-Dec;10(6):e508-e513. doi: 10.1016/j.prro.2020.01.013. Epub 2020 Mar 7. Pract Radiat Oncol. 2020. PMID: 32151732 Free PMC article.
PURPOSE: We assessed the feasibility and safety of placing a radiopaque hydrogel in the pancreaticoduodenal groove via endoscopic ultrasound guidance in patients with borderline resectable/locally advanced pancreatic cancer (BR/LAPC). METHODS AND MATERIALS: Hydrogel …
PURPOSE: We assessed the feasibility and safety of placing a radiopaque hydrogel in the pancreaticoduodenal groove via endoscopic ult …
Dose-Escalated Radiation Therapy for Pancreatic Cancer: A Simultaneous Integrated Boost Approach.
Koay EJ, Hanania AN, Hall WA, Taniguchi CM, Rebueno N, Myrehaug S, Aitken KL, Dawson LA, Crane CH, Herman JM, Erickson B. Koay EJ, et al. Pract Radiat Oncol. 2020 Nov-Dec;10(6):e495-e507. doi: 10.1016/j.prro.2020.01.012. Epub 2020 Feb 13. Pract Radiat Oncol. 2020. PMID: 32061993 Free PMC article.
PURPOSE: To provide a detailed description of practical approaches to dose escalation in pancreatic cancer. METHODS AND MATERIALS: The current paper represents an international collaborative effort of radiation oncologists from the MR-linac consortium with expertise in …
PURPOSE: To provide a detailed description of practical approaches to dose escalation in pancreatic cancer. METHODS AND MATERIALS: Th …
Colorectal liver metastases: Current management and future perspectives.
Martin J, Petrillo A, Smyth EC, Shaida N, Khwaja S, Cheow HK, Duckworth A, Heister P, Praseedom R, Jah A, Balakrishnan A, Harper S, Liau S, Kosmoliaptsis V, Huguet E. Martin J, et al. World J Clin Oncol. 2020 Oct 24;11(10):761-808. doi: 10.5306/wjco.v11.i10.761. World J Clin Oncol. 2020. PMID: 33200074 Free PMC article. Review.
For unresectable patients, treatment options including systemic chemotherapy, targeted biological agents, intra-arterial infusion or bead delivered chemotherapy, tumour ablation, stereotactic radiotherapy, and selective internal radiotherapy contribute to imp …
For unresectable patients, treatment options including systemic chemotherapy, targeted biological agents, intra-arterial infusion or bead de …
Twenty-year survival after iterative surgery for metastatic renal cell carcinoma: A case report and review of literature.
De Raffele E, Mirarchi M, Casadei R, Ricci C, Brunocilla E, Minni F. De Raffele E, et al. World J Clin Cases. 2020 Oct 6;8(19):4450-4465. doi: 10.12998/wjcc.v8.i19.4450. World J Clin Cases. 2020. PMID: 33083404 Free PMC article.
The subsequent clinical course was characterized by multiple sequential abdominal and thoracic recurrences, successfully treated with multiple systemic treatments, repeated local treatments, including two pancreatic resections, conservative resection and ablation of multip …
The subsequent clinical course was characterized by multiple sequential abdominal and thoracic recurrences, successfully treated with multip …
[Gastric and pancreatic cancers: Will neoadjuvant (chemo)radiotherapy replace adjuvant chemoradiotherapy?].
Huguet F, Rivin Del Campo E, Labidi M, Ménard J, Sergent G, Durand B, Quéro L. Huguet F, et al. Cancer Radiother. 2020 Oct;24(6-7):493-500. doi: 10.1016/j.canrad.2020.05.006. Epub 2020 Aug 16. Cancer Radiother. 2020. PMID: 32814670 Review. French.
For many years, adjuvant chemoradiotherapy remained essential in the therapeutic management of gastric and pancreatic adenocarcinomas. For these tumours, surgical excision, the only hope of offering the patient prolonged survival, is only possible in 20% of cases. ...Neoad …
For many years, adjuvant chemoradiotherapy remained essential in the therapeutic management of gastric and pancreatic adenocarcinomas …
A Rare Case of Pancreatoblastoma with Intracranial Seeding.
Snyder MH, Ampie L, Mandell JW, Helm GA, Syed HR. Snyder MH, et al. World Neurosurg. 2020 Oct;142:334-338. doi: 10.1016/j.wneu.2020.06.210. Epub 2020 Jul 1. World Neurosurg. 2020. PMID: 32622062
BACKGROUND: Pancreatoblastoma is an extremely rare neoplasm that accounts for 0.5% of all pancreatic exocrine tumors. ...Metastatic disease was suspected, and the patient underwent suboccipital craniotomy for tumor resection with adjuvant gamma knife radiosurgery …
BACKGROUND: Pancreatoblastoma is an extremely rare neoplasm that accounts for 0.5% of all pancreatic exocrine tumors. ...Metas …
Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma.
Han BJ, Murphy JD, Qin S, Ye J, Uccello TP, Garrett-Larsen J, Belt BA, Prieto PA, Egilmez NK, Lord EM, Linehan DC, Mills BN, Gerber SA. Han BJ, et al. Immunol Invest. 2020 Oct;49(7):808-823. doi: 10.1080/08820139.2020.1765795. Epub 2020 Jun 4. Immunol Invest. 2020. PMID: 32498585 Free PMC article.
METHODS: Fluorescent MS were injected into orthotopically implanted murine pancreatic tumors, and tissues were examined by whole-mount microscopy and imaging flow cytometry. The role of the TDLN was investigated for mice treated with intratumoral interleukin-12 (IL-12)-enc …
METHODS: Fluorescent MS were injected into orthotopically implanted murine pancreatic tumors, and tissues were examined by whole-moun …
Novel MR-Guided Radiotherapy Elective Rotation for Radiation Oncology Trainees.
Sim AJ, Frakes JM, Hoffe SE, Wuthrick E, Dilling TJ, Rosenberg S. Sim AJ, et al. Cureus. 2020 Sep 29;12(9):e10706. doi: 10.7759/cureus.10706. Cureus. 2020. PMID: 33133871 Free PMC article.
To increase the diversity of elective offerings and improve the understanding of an MR-guided radiotherapy program, we initiated a unique MR-guided radiotherapy elective rotation for radiation oncology residents. During a representative four-week rotation, 21 simula …
To increase the diversity of elective offerings and improve the understanding of an MR-guided radiotherapy program, we initiated a un …
Stereotactic Radiotherapy for Pancreatic Cancer: A Single-Institution Experience.
Glicksman RM, Chung H, Myrehaug S, Erler D, Korol R, Karotki A, Taggar A, Ung YC. Glicksman RM, et al. Cureus. 2020 Sep 23;12(9):e10618. doi: 10.7759/cureus.10618. Cureus. 2020. PMID: 33123432 Free PMC article.
Introduction Despite treatment advances, the prognosis of locally advanced pancreatic cancer is poor. Treatment remains varied and includes systemic and radiotherapy (RT). Stereotactic body radiotherapy (SBRT), highly conformal high-dose RT per fractio …
Introduction Despite treatment advances, the prognosis of locally advanced pancreatic cancer is poor. Treatment remains varied and in …
Role of endoscopic ultrasonography guided fiducial marker placement in gastrointestinal cancer.
Kerdsirichairat T, Shin EJ. Kerdsirichairat T, et al. Curr Opin Gastroenterol. 2020 Sep;36(5):402-408. doi: 10.1097/MOG.0000000000000662. Curr Opin Gastroenterol. 2020. PMID: 32740001 Review.
PURPOSE OF REVIEW: Dose escalation radiation therapy such as those delivered by stereotactic body radiation therapy (SBRT) has shown to improve local disease control in multiple types of malignancies. ...The purpose of this review is to provide updates of recent high-quali …
PURPOSE OF REVIEW: Dose escalation radiation therapy such as those delivered by stereotactic body radiation therapy (SBRT) has shown …
On-line adaptive MR guided radiotherapy for locally advanced pancreatic cancer: Clinical and dosimetric considerations.
Placidi L, Romano A, Chiloiro G, Cusumano D, Boldrini L, Cellini F, Mattiucci GC, Valentini V. Placidi L, et al. Tech Innov Patient Support Radiat Oncol. 2020 Jul 2;15:15-21. doi: 10.1016/j.tipsro.2020.06.001. eCollection 2020 Sep. Tech Innov Patient Support Radiat Oncol. 2020. PMID: 32642565 Free PMC article.
The aim of this study is to evaluate feasibility and the dosimetric improvement of the OA workflow implemented in our institution for locally advanced pancreatic cancer (LAPC) patients, in terms of target coverage and organs at risk (OARs) sparing. ...CONCLUSION: OA workfl …
The aim of this study is to evaluate feasibility and the dosimetric improvement of the OA workflow implemented in our institution for locall …
The yield of chest computed tomography in patients with locally advanced pancreatic cancer.
Suker M, Groot Koerkamp B, Nuyttens JJ, Dwarkasing RS, Homs MYV, Eskens FALM, van Eijck CHJ. Suker M, et al. J Surg Oncol. 2020 Sep;122(3):450-456. doi: 10.1002/jso.25968. Epub 2020 May 6. J Surg Oncol. 2020. PMID: 32378193 Free PMC article.
OBJECTIVE: To evaluate the incidence of pulmonary metastases on chest computed tomography (CT) in patients with locally advanced pancreatic cancer (LAPC). METHODS: All patients diagnosed with LAPC in a single tertiary center (Erasmus MC) between October 2011 and December 2 …
OBJECTIVE: To evaluate the incidence of pulmonary metastases on chest computed tomography (CT) in patients with locally advanced pancreat …
A prospective observational study of the clinical and pathological impact of stereotactic body radiotherapy (SBRT) as a neoadjuvant strategy of chemoradiation in pancreatic cancer.
Chen-Zhao X, Hernando O, López M, Sánchez E, Montero A, García-Aranda M, Ciérvide R, Valero J, Alonso R, Cárdenas-Rebollo JM, Vicente E, Quijano Y, Cubillo A, Álvarez R, Prados S, Plaza C, García J, Zucca D, Fernández-Letón P, Rubio C. Chen-Zhao X, et al. Clin Transl Oncol. 2020 Sep;22(9):1499-1505. doi: 10.1007/s12094-020-02287-w. Epub 2020 Jan 23. Clin Transl Oncol. 2020. PMID: 31974820
[MRI-guided radiotherapy: An innovation for patients with upper abdominal malignancies].
Daamen LA, Heerkens HD, Molenaar IQQ, Verkooijen HLM, Meijer GJ, Intven MPW. Daamen LA, et al. Ned Tijdschr Geneeskd. 2020 Aug 13;164:D4780. Ned Tijdschr Geneeskd. 2020. PMID: 32940972 Dutch.
MRI-guided radiotherapy is a new technique for high-precision radiation(stereotactic radiotherapy) for patients with malignancies. ...MRI-guided radiotherapy can have advantages when treating patients with malignancies in the upper abdomen, such as …
MRI-guided radiotherapy is a new technique for high-precision radiation(stereotactic radiotherapy) for patients with ma …
Quality assurance of IMRT treatment plans for a 1.5 T MR-linac using a 2D ionization chamber array and a static solid phantom.
Mönnich D, Winter J, Nachbar M, Künzel L, Boeke S, Gani C, Dohm O, Zips D, Thorwarth D. Mönnich D, et al. Phys Med Biol. 2020 Aug 13;65(16):16NT01. doi: 10.1088/1361-6560/aba5ec. Phys Med Biol. 2020. PMID: 32663819
MR-guided radiotherapy requires novel quality assurance (QA) methods for intensity-modulated radiotherapy treatment plans (TPs). ...Pass rates depended on the tumour entity. Median pass rates were for liver metastases stereotactic body radiotherapy 99. …
MR-guided radiotherapy requires novel quality assurance (QA) methods for intensity-modulated radiotherapy treatment plans (TPs …
Initial clinical experience of Stereotactic Body Radiation Therapy (SBRT) for liver metastases, primary liver malignancy, and pancreatic cancer with 4D-MRI based online adaptation and real-time MRI monitoring using a 1.5 Tesla MR-Linac.
Hall WA, Straza MW, Chen X, Mickevicius N, Erickson B, Schultz C, Awan M, Ahunbay E, Li XA, Paulson ES. Hall WA, et al. PLoS One. 2020 Aug 7;15(8):e0236570. doi: 10.1371/journal.pone.0236570. eCollection 2020. PLoS One. 2020. PMID: 32764748 Free PMC article.
Tumor types included liver metastatic lesions from melanoma and sarcoma, primary liver hepatocellular carcinoma (HCC), and regional abdominal tumors included pancreatic metastatic lesions from renal cell carcinoma (RCC) along with two cases of recurrent pancreatic c …
Tumor types included liver metastatic lesions from melanoma and sarcoma, primary liver hepatocellular carcinoma (HCC), and regional abdomina …
Patterns of Failure After Neoadjuvant Stereotactic Body Radiation Therapy or Fractionated Chemoradiation in Resectable and Borderline Resectable Pancreatic Cancer.
Barrord M, Ahmad S, Patel S, Olowokure O, Sussman J, Smith M, Poreddy S, Esslinger H, Latif T, Choe K, Kharofa J. Barrord M, et al. Pancreas. 2020 Aug;49(7):941-946. doi: 10.1097/MPA.0000000000001602. Pancreas. 2020. PMID: 32658077
OBJECTIVES: The goal of this study was to compare outcomes of patients with borderline and resectable pancreatic cancer treated with neoadjuvant stereotactic body radiation therapy (SBRT) versus fractionated chemoradiation. METHODS: Patients with borderline or resec …
OBJECTIVES: The goal of this study was to compare outcomes of patients with borderline and resectable pancreatic cancer treated with …
Predictive value of 0.35 T magnetic resonance imaging radiomic features in stereotactic ablative body radiotherapy of pancreatic cancer: A pilot study.
Simpson G, Spieler B, Dogan N, Portelance L, Mellon EA, Kwon D, Ford JC, Yang F. Simpson G, et al. Med Phys. 2020 Aug;47(8):3682-3690. doi: 10.1002/mp.14200. Epub 2020 May 16. Med Phys. 2020. PMID: 32329904
PURPOSE: The aim of this study was to evaluate the potential and feasibility of radiomic features extracted from low field strength (0.35 T) magnetic resonance images (MRIs) in predicting treatment response for patients with pancreatic cancer undergoing stereotactic …
PURPOSE: The aim of this study was to evaluate the potential and feasibility of radiomic features extracted from low field strength (0.35 T) …
Novel strategies using modern radiotherapy to improve pancreatic cancer outcomes: toward a new standard?
Bouchart C, Navez J, Closset J, Hendlisz A, Van Gestel D, Moretti L, Van Laethem JL. Bouchart C, et al. Ther Adv Med Oncol. 2020 Jul 7;12:1758835920936093. doi: 10.1177/1758835920936093. eCollection 2020. Ther Adv Med Oncol. 2020. PMID: 32684987 Free PMC article. Review.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive solid tumours with an estimated 5-year overall survival rate of 7% for all stages combined. In this highly resistant disease that is located in the vicinity of many radiosensitive organs, the role o …
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive solid tumours with an estimated 5-year overall survival ra …
Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group.
Nieuwenhuizen S, Puijk RS, van den Bemd B, Aldrighetti L, Arntz M, van den Boezem PB, Bruynzeel AME, Burgmans MC, de Cobelli F, Coolsen MME, Dejong CHC, Derks S, Diederik A, van Duijvendijk P, Eker HH, Engelsman AF, Erdmann JI, Fütterer JJ, Geboers B, Groot G, Haasbeek CJA, Janssen JJ, de Jong KP, Kater GM, Kazemier G, Kruimer JWH, Leclercq WKG, van der Leij C, Manusama ER, Meier MAJ, van der Meijs BB, Melenhorst MCAM, Nielsen K, Nijkamp MW, Potters FH, Prevoo W, Rietema FJ, Ruarus AH, Ruiter SJS, Schouten EAC, Serafino GP, Sietses C, Swijnenburg RJ, Timmer FEF, Versteeg KS, Vink T, de Vries JJJ, de Wilt JHW, Zonderhuis BM, Scheffer HJ, van den Tol PMP, Meijerink MR. Nieuwenhuizen S, et al. Cancers (Basel). 2020 Jul 3;12(7):1779. doi: 10.3390/cancers12071779. Cancers (Basel). 2020. PMID: 32635230 Free PMC article.
Thermal ablation is reserved for unresectable CRLM, deep-seated resectable CRLM and can be considered when patients are in poor health. Irreversible electroporation and stereotactic body radiotherapy can be considered for unresectable perihilar and perivascular CRLM …
Thermal ablation is reserved for unresectable CRLM, deep-seated resectable CRLM and can be considered when patients are in poor health. Irre …
Single-Fraction Stereotactic Body Radiation Therapy: A Paradigm During the Coronavirus Disease 2019 (COVID-19) Pandemic and Beyond?
Ng SSW, Ning MS, Lee P, McMahon RA, Siva S, Chuong MD. Ng SSW, et al. Adv Radiat Oncol. 2020 Jun 24;5(4):761-773. doi: 10.1016/j.adro.2020.06.011. eCollection 2020 Jul-Aug. Adv Radiat Oncol. 2020. PMID: 32775790 Free PMC article. Review.
RESULTS: Single-fraction SBRT for peripheral early-stage non-small cell lung cancer is supported by randomized data and is strongly endorsed during the COVID-19 pandemic by the European Society for Radiotherapy and Oncology-American Society for Radiation Oncology practice …
RESULTS: Single-fraction SBRT for peripheral early-stage non-small cell lung cancer is supported by randomized data and is strongly endorsed …
Radiation as a Single-Modality Treatment in Localized Pancreatic Cancer.
Shaib WL, Zakka K, Shahin AA, Yared F, Switchenko JM, Wu C, Akce M, Alese OB, Patel PR, Mcdonald M, El-Rayes BF. Shaib WL, et al. Pancreas. 2020 Jul;49(6):822-829. doi: 10.1097/MPA.0000000000001584. Pancreas. 2020. PMID: 32541638 Free PMC article.
OBJECTIVES: Locally advanced pancreatic cancer (LAPC) is managed with multimodality therapy. We aim to evaluate the outcome of single-modality radiation therapy for LAPC. ...Tumors of 4 cm or greater (>T3 stage) accounted for 52.7%. The median radiation dose was 39.6 Gy …
OBJECTIVES: Locally advanced pancreatic cancer (LAPC) is managed with multimodality therapy. We aim to evaluate the outcome of single …
Multi-institution validation of a new high spatial resolution diode array for SRS and SBRT plan pretreatment quality assurance.
Rose MS, Tirpak L, Van Casteren K, Zack J, Simon T, Schoenfeld A, Simon W. Rose MS, et al. Med Phys. 2020 Jul;47(7):3153-3164. doi: 10.1002/mp.14153. Epub 2020 Apr 27. Med Phys. 2020. PMID: 32215929
PURPOSE: The SRS MapCHECK() , a recently developed patient-specific quality assurance (PSQA) tool for end-to-end testing of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT), was evaluated in a multi-institution study and compared …
PURPOSE: The SRS MapCHECK() , a recently developed patient-specific quality assurance (PSQA) tool for end-to-end testing of stereotactic …
The Utility of Stereotactic Ablative Radiation Therapy for Palliation of Metastatic Pancreatic Adenocarcinoma.
Koong AJ, Toesca DAS, Baclay JRM, Pollom EL, von Eyben R, Koong AC, Chang DT. Koong AJ, et al. Pract Radiat Oncol. 2020 Jul-Aug;10(4):274-281. doi: 10.1016/j.prro.2020.02.010. Epub 2020 Feb 29. Pract Radiat Oncol. 2020. PMID: 32119922
PURPOSE: Our purpose was to report the outcome of stereotactic ablative radiation therapy (SABR) to the primary tumor for patients with metastatic pancreatic cancer. METHODS AND MATERIALS: We examined the records of patients with metastatic pancreatic cancer …
PURPOSE: Our purpose was to report the outcome of stereotactic ablative radiation therapy (SABR) to the primary tumor for patients wi …
Setup Management for Stereotactic Body Radiation Therapy of Patients With Pancreatic Cancer Treated via the Breath-Hold Technique.
Teboh RF, Srinivasan S, Ng SP, Aliru ML, Herman JM. Teboh RF, et al. Pract Radiat Oncol. 2020 Jul-Aug;10(4):e280-e289. doi: 10.1016/j.prro.2019.10.012. Epub 2019 Oct 25. Pract Radiat Oncol. 2020. PMID: 31669403
Determining a safe range of values for such adjustments is an important quality assurance measure and was the purpose of this study, with focus on stereotactic body radiation therapy in patients with pancreatic cancer. ...
Determining a safe range of values for such adjustments is an important quality assurance measure and was the purpose of this study, with fo …
Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines.
Cellini F, Arcelli A, Simoni N, Caravatta L, Buwenge M, Calabrese A, Brunetti O, Genovesi D, Mazzarotto R, Deodato F, Mattiucci GC, Silvestris N, Valentini V, Morganti AG. Cellini F, et al. Cancers (Basel). 2020 Jun 29;12(7):1729. doi: 10.3390/cancers12071729. Cancers (Basel). 2020. PMID: 32610592 Free PMC article. Review.
Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. ...This review will focus on i) the current indications by the available national and international guidelines; ii) the current standard indications …
Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. ...This …
Neuroendocrine Carcinoma of Uterine Cervix: Stereotactic Radiotherapy for Brain Metastasis and Stereotactic Body Radiotherapy for Renal and Pancreatic Metastases.
Mori Y, Kida Y, Matsushita Y, Mizumatsu S, Hatano M, Morita N, Tsuzuki T. Mori Y, et al. Cureus. 2020 Jun 27;12(6):e8869. doi: 10.7759/cureus.8869. Cureus. 2020. PMID: 32754406 Free PMC article.
In addition, a brainstem metastasis causing neurologic signs developed. The brain lesion was treated by stereotactic radiotherapy (SRT) and the renal and pancreatic lesions by stereotactic body radiotherapy (SBRT). ...Recurrence and newly develo …
In addition, a brainstem metastasis causing neurologic signs developed. The brain lesion was treated by stereotactic radiotherapy …
Reliability of ITV approach to varying treatment fraction time: a retrospective analysis based on 2D cine MR images.
Cusumano D, Dhont J, Boldrini L, Chiloiro G, Romano A, Votta C, Longo S, Placidi L, Azario L, De Spirito M, Verellen D, Valentini V. Cusumano D, et al. Radiat Oncol. 2020 Jun 12;15(1):152. doi: 10.1186/s13014-020-01530-6. Radiat Oncol. 2020. PMID: 32532334 Free PMC article.
BACKGROUND: Internal Target Volume (ITV) is one of the most common strategies to passively manage tumour motion in Radiotherapy (RT). The reliability of this approach is based on the assumption that the tumour motion estimated during pre-treatment 4D Computed Tomography (C …
BACKGROUND: Internal Target Volume (ITV) is one of the most common strategies to passively manage tumour motion in Radiotherapy (RT). …
Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Derived Imaging Metrics for Stereotactic Body Radiotherapy of Pancreatic Ductal Adenocarcinoma: Preliminary Findings.
Kinh Do R, Reyngold M, Paudyal R, Oh JH, Konar AS, LoCastro E, Goodman KA, Shukla-Dave A. Kinh Do R, et al. Tomography. 2020 Jun;6(2):261-271. doi: 10.18383/j.tom.2020.00015. Tomography. 2020. PMID: 32548304 Free PMC article.
We aimed to assess longitudinal changes in quantitative imaging metric values obtained from diffusion-weighted (DW-) and dynamic contrast-enhanced magnetic resonance imaging (DCE)-MRI at pre-treatment (TX[0]), immediately after the first fraction of stereotactic body ra …
We aimed to assess longitudinal changes in quantitative imaging metric values obtained from diffusion-weighted (DW-) and dynamic contrast-en …
Deep Learning model for markerless tracking in spinal SBRT.
Roggen T, Bobic M, Givehchi N, Scheib SG. Roggen T, et al. Phys Med. 2020 Jun;74:66-73. doi: 10.1016/j.ejmp.2020.04.029. Epub 2020 May 15. Phys Med. 2020. PMID: 32422577
Stereotactic Body Radiation Therapy (SBRT), alternatively termed Stereotactic ABlative Radiotherapy (SABR) or Stereotactic RadioSurgery (SRS), delivers high dose with a sub-millimeter accuracy. ...To allow for dose escalation within the target w …
Stereotactic Body Radiation Therapy (SBRT), alternatively termed Stereotactic ABlative Radiotherapy (SABR) or Stereo …
Standardized thresholds of volume-based PET/CT parameters predicting survival of patients with pancreatic head cancer treated with stereotactic body radiation therapy.
Su W, Ren S, Zhu X, Zhang H, Zuo C. Su W, et al. Ann Nucl Med. 2020 Jun;34(6):379-387. doi: 10.1007/s12149-020-01454-x. Epub 2020 Apr 10. Ann Nucl Med. 2020. PMID: 32277421
OBJECTIVE: To explore standardized relative thresholds of volume-based parameters on FDG PET/CT, and define the optimal prognosticator among the relative thresholds for patients with locally advanced pancreatic head cancer (LAPHC) treated by stereotactic body radiat …
OBJECTIVE: To explore standardized relative thresholds of volume-based parameters on FDG PET/CT, and define the optimal prognosticator among …
Conventionally fractionated radiation therapy versus stereotactic body radiation therapy for locally advanced pancreatic cancer (CRiSP): An international systematic review and meta-analysis.
Tchelebi LT, Lehrer EJ, Trifiletti DM, Sharma NK, Gusani NJ, Crane CH, Zaorsky NG. Tchelebi LT, et al. Cancer. 2020 May 15;126(10):2120-2131. doi: 10.1002/cncr.32756. Epub 2020 Mar 3. Cancer. 2020. PMID: 32125712 Free article.
BACKGROUND: The goal of this study was to characterize the efficacy and safety of stereotactic body radiation therapy (SBRT) versus conventionally fractionated radiation therapy with concurrent chemotherapy (CFRT) for the definitive treatment of locally advanced pancrea …
BACKGROUND: The goal of this study was to characterize the efficacy and safety of stereotactic body radiation therapy (SBRT) versus c …
Immune Checkpoint Blockade in Combination with Stereotactic Body Radiotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma.
Xie C, Duffy AG, Brar G, Fioravanti S, Mabry-Hrones D, Walker M, Bonilla CM, Wood BJ, Citrin DE, Gil Ramirez EM, Escorcia FE, Redd B, Hernandez JM, Davis JL, Gasmi B, Kleiner D, Steinberg SM, Jones JC, Greten TF. Xie C, et al. Clin Cancer Res. 2020 May 15;26(10):2318-2326. doi: 10.1158/1078-0432.CCR-19-3624. Epub 2020 Jan 29. Clin Cancer Res. 2020. PMID: 31996388 Free PMC article. Clinical Trial.
PURPOSE: The effectiveness of immune checkpoint inhibitors (ICI) is limited in pancreatic ductal adenocarcinoma (PDAC). We conducted a phase I study to evaluate the safety of ICI with stereotactic body radiation therapy (SBRT) in patients with metastatic PDAC. ...
PURPOSE: The effectiveness of immune checkpoint inhibitors (ICI) is limited in pancreatic ductal adenocarcinoma (PDAC). We conducted …
Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer.
Ji K, Shao YJ, Hao JL, Cheng XJ, Guan BQ, Liu WS, Chen L, Wang X, Song YC, Wang K, Wang P. Ji K, et al. J Pain Res. 2020 May 4;13:919-925. doi: 10.2147/JPR.S247303. eCollection 2020. J Pain Res. 2020. PMID: 32440197 Free PMC article.
PURPOSE: This study evaluated the analgesic effect of stereotactic body radiotherapy (SBRT) in combination with celiac plexus block (CPB), relative to SBRT alone, in locally advanced pancreatic cancer (LAPC) patients. ...
PURPOSE: This study evaluated the analgesic effect of stereotactic body radiotherapy (SBRT) in combination with celiac plexus …
Australasian Gastrointestinal Trials Group (AGITG) and Trans-Tasman Radiation Oncology Group (TROG) Guidelines for Pancreatic Stereotactic Body Radiation Therapy (SBRT).
Oar A, Lee M, Le H, Hruby G, Dalfsen R, Pryor D, Lee D, Chu J, Holloway L, Briggs A, Barbour A, Chander S, Ng SP, Samra J, Shakeshaft J, Goldstein D, Nguyen N, Goodman KA, Chang DT, Kneebone A. Oar A, et al. Pract Radiat Oncol. 2020 May-Jun;10(3):e136-e146. doi: 10.1016/j.prro.2019.07.018. Epub 2019 Nov 21. Pract Radiat Oncol. 2020. PMID: 31761541
PURPOSE: Nonrandomized data exploring pancreas stereotactic body radiation therapy (SBRT) has demonstrated excellent local control rates and low toxicity. ...In addition, dose constraints, stepwise contouring guidelines, and an anatomic atlas for pancreatic S …
PURPOSE: Nonrandomized data exploring pancreas stereotactic body radiation therapy (SBRT) has demonstrated excellent local con …
Pancreas SBRT: Who, What, When, Where, and How.
Bernard V, Herman JM. Bernard V, et al. Pract Radiat Oncol. 2020 May-Jun;10(3):183-185. doi: 10.1016/j.prro.2019.11.005. Epub 2019 Nov 21. Pract Radiat Oncol. 2020. PMID: 31760165 No abstract available.
Radiomics-Based Outcome Prediction for Pancreatic Cancer Following Stereotactic Body Radiotherapy.
Parr E, Du Q, Zhang C, Lin C, Kamal A, McAlister J, Liang X, Bavitz K, Rux G, Hollingsworth M, Baine M, Zheng D. Parr E, et al. Cancers (Basel). 2020 Apr 24;12(4):1051. doi: 10.3390/cancers12041051. Cancers (Basel). 2020. PMID: 32344538 Free PMC article.
Currently available clinical prediction models poorly predict treatment outcomes in pancreatic adenocarcinoma. Therefore, we used radiomic features of primary pancreatic tumors to develop outcome prediction models and compared them to traditional clinical models. (2 …
Currently available clinical prediction models poorly predict treatment outcomes in pancreatic adenocarcinoma. Therefore, we used rad …
[A Case of Anaplastic Carcinoma with Osteoclastlike Giant Cells of the Pancreas Concomitant with Lung Recurrence of Solitary Fibrous Tumor].
Zhou D, Kagawa S, Sato Y, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Takano S, Suzuki D, Sakai N, Nojima H, Mishima T, Nakadai E, Ohtsuka M. Zhou D, et al. Gan To Kagaku Ryoho. 2020 Apr;47(4):685-687. Gan To Kagaku Ryoho. 2020. PMID: 32389984 Japanese.
When she was 31 years old, it had recurred but was cured by gamma knife radiosurgery. We performed distal pancreatectomy and splenectomy with lymph node dissection. ...Fourteen months since undergoing pancreatectomy, the patient experienced no recurrence from …
When she was 31 years old, it had recurred but was cured by gamma knife radiosurgery. We performed distal pancreatectomy and s …
Volume de-escalation in radiation therapy: state of the art and new perspectives.
Meduri B, Gregucci F, D'Angelo E, Alitto AR, Ciurlia E, Desideri I, Marino L, Borghetti P, Fiore M, Fiorentino A; AIRO Giovani -Italian Association of Radiation Oncology-Young Members. Meduri B, et al. J Cancer Res Clin Oncol. 2020 Apr;146(4):909-924. doi: 10.1007/s00432-020-03152-7. Epub 2020 Feb 18. J Cancer Res Clin Oncol. 2020. PMID: 32072318 Review.
In early breast cancer, partial breast irradiation has been established as a treatment option in low-risk patients. In pancreatic cancer stereotactic body radiotherapy may be used to dose escalation. Stereotactic radiosurgery should be the treat …
In early breast cancer, partial breast irradiation has been established as a treatment option in low-risk patients. In pancreatic can …
Stereotactic ablative radiation therapy for pulmonary metastases: Improving overall survival and identifying subgroups at high risk of local failure.
Pasalic D, Lu Y, Betancourt-Cuellar SL, Taku N, Mesko SM, Bagley AF, Chance WW, Allen PK, Tang C, Antonoff MB, Balter PA, Mehran RJ, Welsh JW, Liao Z, Gomez D, Erasmus JJ, Nguyen QN. Pasalic D, et al. Radiother Oncol. 2020 Apr;145:178-185. doi: 10.1016/j.radonc.2020.01.010. Epub 2020 Feb 7. Radiother Oncol. 2020. PMID: 32044530
BACKGROUND & PURPOSE: Stereotactic ablative radiation therapy (SABR) is an emerging treatment option for patients with pulmonary metastases; identifying patients who would benefit from SABR can improve outcomes. ...RESULTS: Median follow-up time was 23 months. Primary …
BACKGROUND & PURPOSE: Stereotactic ablative radiation therapy (SABR) is an emerging treatment option for patients with pulmonary …
[Ablative treatment options for locally advanced unresectable and borderline resectable pancreatic carcinoma].
Moulla Y, Petersen TO, Maiwald B, Bailis N, Kreuser N, Lordick F, Seehofer D, Sucher R, Hecker M, Hoffmeister A, Jansen-Winkeln B, Gockel I. Moulla Y, et al. Chirurg. 2020 Apr;91(4):319-328. doi: 10.1007/s00104-019-01072-y. Chirurg. 2020. PMID: 31828387 Review. German.
BACKGROUND: Locally advanced unresectable (nonmetastatic) and borderline resectable pancreatic carcinomas represent a therapeutic challenge. Several minimally invasive local ablative techniques are available for local treatment in these situations. OBJECTIVE: Which interve …
BACKGROUND: Locally advanced unresectable (nonmetastatic) and borderline resectable pancreatic carcinomas represent a therapeutic cha …
Prognostic value of 18F-FDG PET /CT metabolic parameters in patients with locally advanced pancreatic Cancer treated with stereotactic body radiation therapy.
Ren S, Zhu X, Zhang A, Li D, Zuo C, Zhang H. Ren S, et al. Cancer Imaging. 2020 Mar 10;20(1):22. doi: 10.1186/s40644-020-00301-6. Cancer Imaging. 2020. PMID: 32156306 Free PMC article.
BACKGROUND: (18)F-FDG PET/CT metabolic parameters have been applied as prognostic factors in multi-malignancies. However, the role in locally advanced pancreatic cancer (LAPC) was not confirmed. In this study, we investigated the prognostic value of (18)F-FDG PET/CT metabo …
BACKGROUND: (18)F-FDG PET/CT metabolic parameters have been applied as prognostic factors in multi-malignancies. However, the role in locall …
Local control and toxicity outcomes of stereotactic radiosurgery for spinal metastases of gastrointestinal origin.
Sandhu N, Benson KRK, Kumar KA, Eyben RV, Chang DT, Gibbs IC, Hancock SL, Meola A, Chang SD, Li G, Hayden-Gephart M, Soltys SG, Pollom EL. Sandhu N, et al. J Neurosurg Spine. 2020 Mar 6;33(1):87-94. doi: 10.3171/2020.1.SPINE191260. J Neurosurg Spine. 2020. PMID: 32114530
The authors report local control and toxicity outcomes of stereotactic radiosurgery (SRS) to spinal metastases from GI primary cancers. ...Histologies included CRC (46%), hepatocellular carcinoma (19%), neuroendocrine carcinoma (13%), pancreatic carcinoma (12 …
The authors report local control and toxicity outcomes of stereotactic radiosurgery (SRS) to spinal metastases from GI primary …
Intrafractional relationship changes between an external breathing signal and fiducial marker positions in pancreatic cancer patients.
Pettersson N, Oderinde OM, Murphy J, Simpson D, Cerviño LI. Pettersson N, et al. J Appl Clin Med Phys. 2020 Mar;21(3):153-161. doi: 10.1002/acm2.12841. Epub 2020 Mar 14. J Appl Clin Med Phys. 2020. PMID: 32170900 Free PMC article.
BACKGROUND AND PURPOSE: The purpose of this study of pancreatic cancer patients treated with respiratory-guided stereotactic body radiotherapy (SBRT) on a standard linac was to investigate (a) the intrafractional relationship change (IRC) between a breathing …
BACKGROUND AND PURPOSE: The purpose of this study of pancreatic cancer patients treated with respiratory-guided stereotactic b …
Performance assessment of a new optimization system for robotic SBRT MLC-based plans.
Calusi S, Doro R, Di Cataldo V, Cipressi S, Francolini G, Bonucci I, Livi L, Masi L. Calusi S, et al. Phys Med. 2020 Mar;71:31-38. doi: 10.1016/j.ejmp.2020.02.009. Epub 2020 Feb 20. Phys Med. 2020. PMID: 32088563 Free article.
METHODS: MLC-plans were created for 25 SBRT cases (liver, prostate, pancreas and spine) using both VOLO and Sequential. Monitor units (MU), delivery time (DT), PTV coverage, conformity (nCI), dose gradient (R50%) and OAR doses were used for comparison and combined to obtai …
METHODS: MLC-plans were created for 25 SBRT cases (liver, prostate, pancreas and spine) using both VOLO and Sequential. Monitor units …
Posterior Fossa Arteriovenous Malformations: Experience with 14 Patients and a Systematic Review of the Literature.
Corniola MV, Meling TR, Bijlenga P, Bernava G, Machi P, Schaller K. Corniola MV, et al. J Neurol Surg A Cent Eur Neurosurg. 2020 Mar;81(2):170-176. doi: 10.1055/s-0039-1691820. Epub 2019 Oct 28. J Neurol Surg A Cent Eur Neurosurg. 2020. PMID: 31659722
The treatments were microsurgery (n = 4), endovascular (n = 3), radiosurgery (n = 2), a combination of two or three treatment modalities (n = 3), or conservative (n = 2). ...In contrast, in ruptured pfAVM cases, mRS was 0 to 2 in four patients (40%), mRS 3 to 4 in two (20% …
The treatments were microsurgery (n = 4), endovascular (n = 3), radiosurgery (n = 2), a combination of two or three treatment modalit …
[A Case of Pulmonary Metastasis from Hilar Cholangiocarcinoma Treated by Stereotactic Body Radiotherapy].
Ishida H, Seyama Y, Ome Y, Matsumura M, Nemoto S, Doi M, Muto J, Hayakawa S, Karasawa K, Horio H, Horiguchi S, Honda G. Ishida H, et al. Gan To Kagaku Ryoho. 2020 Feb;47(2):340-342. Gan To Kagaku Ryoho. 2020. PMID: 32381982 Japanese.
We report a case of pulmonary metastasis from hilar cholangiocarcinoma successfully treated by stereotactic body radiotherapy. The patient was a 70-year-old woman who underwent extended left hemi-hepatectomy with bile duct reconstruction for hilar cholangiocarcinoma …
We report a case of pulmonary metastasis from hilar cholangiocarcinoma successfully treated by stereotactic body radiotherapy. …
Neoadjuvant treatment strategies for resectable pancreas cancer: A propensity-matched analysis of the National Cancer Database.
Xiang M, Heestand GM, Chang DT, Pollom EL. Xiang M, et al. Radiother Oncol. 2020 Feb;143:101-107. doi: 10.1016/j.radonc.2020.01.007. Epub 2020 Feb 7. Radiother Oncol. 2020. PMID: 32044168
BACKGROUND AND PURPOSE: The optimal neoadjuvant approach in patients with resectable pancreas cancer is unclear. We investigated outcomes after preoperative chemotherapy alone, chemotherapy with conventionally-fractionated radiation (CFRT), or chemotherapy with stereota …
BACKGROUND AND PURPOSE: The optimal neoadjuvant approach in patients with resectable pancreas cancer is unclear. We investigated outc …
Aggressive Local Control With Multisite Stereotactic Body Radiation in Metastatic Ewing Sarcoma: A Literature Review and Case Report.
Karimi AM, Campbell SR, Parsai S, Angelov L, Scott J, Qi P, Anderson P, Chao ST, Murphy ES. Karimi AM, et al. Anticancer Res. 2020 Feb;40(2):951-955. doi: 10.21873/anticanres.14028. Anticancer Res. 2020. PMID: 32014939 Review.
Results of the EURO-EWING 99 trial of ES patients showed that local treatment of not only the primary, but also of the sites of metastatic disease should be considered to improve event-free survival. The use of stereotactic body radiotherapy (SBRT) has been extensiv …
Results of the EURO-EWING 99 trial of ES patients showed that local treatment of not only the primary, but also of the sites of metastatic d …
Two cases of Hemosuccus pancreaticus after stereotactic radiotherapy to the pancreas: A case study.
Pezzulla D, Loi M, Suker M, van Eijck C, Nuyttens J. Pezzulla D, et al. Cancer Radiother. 2020 Feb;24(1):60-63. doi: 10.1016/j.canrad.2019.09.003. Epub 2020 Jan 21. Cancer Radiother. 2020. PMID: 31980360
We present 2 cases of patients who underwent stereotactic radiotherapy for pancreatic lesions who manifested signs of HP after treatment. Two male patients were diagnosed with an inoperable locally advanced pancreatic cancer and underwent 8 cycles of c …
We present 2 cases of patients who underwent stereotactic radiotherapy for pancreatic lesions who manifested signs of H …
[Stereotactic body radiotherapy: Passing fad or revolution?].
Vallard A, Vial N, Jmour O, Rehailia-Blanchard A, Trone JC, Sotton S, Daguenet E, Guy JB, Magné N. Vallard A, et al. Bull Cancer. 2020 Feb;107(2):244-253. doi: 10.1016/j.bulcan.2019.09.011. Epub 2019 Dec 19. Bull Cancer. 2020. PMID: 31864665 Review. French.
Stereotactic body radiotherapy (SBRT) is a young technology that can deliver a high dose of radiation to the target, utilizing either a single dose or a small number of fractions with a high degree of precision within the body. ...
Stereotactic body radiotherapy (SBRT) is a young technology that can deliver a high dose of radiation to the target, utilizing …
Is there an oligometastatic state in pancreatic cancer? Practical clinical considerations raise the question.
Scorsetti M, Comito T, Franceschini D, Franzese C, Prete MG, D'Alessio A, Bozzarelli S, Rimassa L, Santoro A. Scorsetti M, et al. Br J Radiol. 2020 Feb 1;93(1106):20190627. doi: 10.1259/bjr.20190627. Epub 2019 Dec 18. Br J Radiol. 2020. PMID: 31825664 Free PMC article.
OBJECTIVES: To evaluate the role of stereotactic body radiotherapy (SBRT) as a local ablative treatment (LAT) in oligometastatic pancreatic cancer. ...ADVANCES IN KNOWLEDGE: Selected patients affected by oligometastatic pancreatic adenocarcinoma can be …
OBJECTIVES: To evaluate the role of stereotactic body radiotherapy (SBRT) as a local ablative treatment (LAT) in oligometastat …
Shear Wave Elastography Can Differentiate between Radiation-Responsive and Non-responsive Pancreatic Tumors: An ex Vivo Study with Murine Models.
Wang H, Mills B, Mislati R, Ahmed R, Gerber SA, Linehan D, Doyley MM. Wang H, et al. Ultrasound Med Biol. 2020 Feb;46(2):393-404. doi: 10.1016/j.ultrasmedbio.2019.10.005. Epub 2019 Nov 11. Ultrasound Med Biol. 2020. PMID: 31727378 Free PMC article.
Neither contrast-enhanced computed tomography nor magnetic resonance imaging can monitor changes in the pancreatic ductal adenocarcinoma microenvironment during therapy. We hypothesized that shear wave elastography could overcome this limitation. To test this hypothesis, w …
Neither contrast-enhanced computed tomography nor magnetic resonance imaging can monitor changes in the pancreatic ductal adenocarcin …
Clinical outcomes and prognostic factors of stereotactic body radiation therapy combined with gemcitabine plus capecitabine for locally advanced unresectable pancreatic cancer.
Shen ZT, Zhou H, Li AM, Ji XQ, Jiang CC, Yuan X, Li B, Zhu XX, Huang GC. Shen ZT, et al. J Cancer Res Clin Oncol. 2020 Feb;146(2):417-428. doi: 10.1007/s00432-019-03066-z. Epub 2019 Oct 30. J Cancer Res Clin Oncol. 2020. PMID: 31667573
PURPOSE: This study aimed to evaluate the clinical outcomes, toxicity, and prognostic factors of SBRT combined with gemcitabine plus capecitabine (GEM-CAP) in treating locally advanced pancreatic cancer (LAPC). METHODS: A total of 56 patients with LAPC treated with SBRT co …
PURPOSE: This study aimed to evaluate the clinical outcomes, toxicity, and prognostic factors of SBRT combined with gemcitabine plus capecit …
Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy.
Taylor E, Zhou J, Lindsay P, Foltz W, Cheung M, Siddiqui I, Hosni A, Amir AE, Kim J, Hill RP, Jaffray DA, Hedley DW. Taylor E, et al. Sci Rep. 2020 Jan 31;10(1):1638. doi: 10.1038/s41598-019-57364-0. Sci Rep. 2020. PMID: 32005829 Free PMC article.
Recent advances in RT have led to an increase in the use stereotactic body radiotherapy (SBRT), which delivers high doses in five or fewer fractions. For cancers such as pancreatic adenocarcinoma for which hypoxia varies significantly between patients, SBRT m …
Recent advances in RT have led to an increase in the use stereotactic body radiotherapy (SBRT), which delivers high doses in f …
Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs: A case report.
Nam NH, Taura K, Kanai M, Fukuyama K, Uza N, Maeda H, Yutaka Y, Chen-Yoshikawa TF, Muto M, Uemoto S. Nam NH, et al. World J Gastroenterol. 2020 Jan 21;26(3):366-374. doi: 10.3748/wjg.v26.i3.366. World J Gastroenterol. 2020. PMID: 31988595 Free PMC article.
Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated. In addition to histopathological results, a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile …
Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated. In addition to histo …
[Radiosurgical hypophysectomy in cancer pain treatment. Literature review and clinical case].
Golanov AV, Kostjuchenko VV, Antipina NA, Isagulyan ED, Makashova ES, Abuzarova GR, Astafyeva LI, Savateev AN, Asriyants SV. Golanov AV, et al. Zh Vopr Neirokhir Im N N Burdenko. 2020;84(5):102-109. doi: 10.17116/neiro202084051102. Zh Vopr Neirokhir Im N N Burdenko. 2020. PMID: 33095538 Review. Russian.
The case of successful relief of resistant pain in patient with pancreatic cancer by means of radiosurgical hypophysectomy is described....
The case of successful relief of resistant pain in patient with pancreatic cancer by means of radiosurgical hypophysectomy is describ …
Dosimetric Comparison of Treatment Plans Computed With Finite Size Pencil Beam and Monte Carlo Algorithms Using the InCise™ Multileaf Collimator-Equipped Cyberknife® System.
Galpayage Dona KNU, Shang C, Leventouri T. Galpayage Dona KNU, et al. J Med Phys. 2020 Jan-Mar;45(1):7-15. doi: 10.4103/jmp.JMP_64_19. Epub 2020 Mar 13. J Med Phys. 2020. PMID: 32355430 Free PMC article.
In the present study, the dose disparities between MC and FSPB algorithms for selected Stereotactic Ablative Radiation Therapy (SABR) CK-MLC treatment plans are quantified. ...No significant dose differences are found in intracranial (0.3%, n = 21) and pancreatic (0 …
In the present study, the dose disparities between MC and FSPB algorithms for selected Stereotactic Ablative Radiation Therapy (SABR) …
Higher Biologically Effective Dose Predicts Survival in SBRT of Pancreatic Cancer: A Multicentric Analysis (PAULA-1).
Arcelli A, Guido A, Buwenge M, Simoni N, Mazzarotto R, Macchia G, Deodato F, Cilla S, Bonomo P, Scotti V, Belgioia L, Tolento G, Cellini F, Grassi E, DI Marco M, Casadei R, Morganti AG, Cammelli S. Arcelli A, et al. Anticancer Res. 2020 Jan;40(1):465-472. doi: 10.21873/anticanres.13975. Anticancer Res. 2020. PMID: 31892602
AIM: The purpose of the present multicentric study was to review stereotactic body radiotherapy (SBRT) with or without chemotherapy (CHT) experience in locally advanced pancreatic cancer (LAPC). ...
AIM: The purpose of the present multicentric study was to review stereotactic body radiotherapy (SBRT) with or without chemoth …
Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer.
Ye J, Mills BN, Zhao T, Han BJ, Murphy JD, Patel AP, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA. Ye J, et al. Cancer Immunol Res. 2020 Jan;8(1):94-107. doi: 10.1158/2326-6066.CIR-19-0373. Epub 2019 Nov 12. Cancer Immunol Res. 2020. PMID: 31719057 Free PMC article.
Pancreatic ductal adenocarcinoma (PDAC) continues to have a dismal prognosis, in part, due to ineffective treatment strategies. ...Using murine models of PDAC, we demonstrated that concurrent administration of stereotactic body radiotherapy (SBRT) and a modif …
Pancreatic ductal adenocarcinoma (PDAC) continues to have a dismal prognosis, in part, due to ineffective treatment strategies. ...Us …
An open-label, single-arm pilot study of EUS-guided brachytherapy with phosphorus-32 microparticles in combination with gemcitabine +/- nab-paclitaxel in unresectable locally advanced pancreatic cancer (OncoPaC-1): Technical details and study protocol.
Bhutani MS, Klapman JB, Tuli R, El-Haddad G, Hoffe S, Wong FCL, Chasen B, Fogelman DR, Lo SK, Nissen NN, Hendifar AE, Varadhachary G, Katz MHG, Erwin WD, Koay EJ, Tamm EP, Singh BS, Mehta R, Wolff RA, Soman A, Cazacu IM, Herman JM. Bhutani MS, et al. Endosc Ultrasound. 2020 Jan-Feb;9(1):24-30. doi: 10.4103/eus.eus_44_19. Endosc Ultrasound. 2020. PMID: 31670288 Free PMC article.
Current treatment options for patients with unresectable locally advanced pancreatic cancer (LAPC) include chemotherapy alone or followed by chemoradiation or stereotactic body radiotherapy. ...Therefore, novel treatment options are needed. Currently, there i …
Current treatment options for patients with unresectable locally advanced pancreatic cancer (LAPC) include chemotherapy alone or foll …
Efficacy and feasibility of stereotactic radiotherapy after folfirinox in patients with locally advanced pancreatic cancer (LAPC-1 trial).
Suker M, Nuyttens JJ, Eskens FALM, Haberkorn BCM, Coene PLO, van der Harst E, Bonsing BA, Vahrmeijer AL, Mieog JSD, Jan Swijnenburg R, Roos D, Koerkamp BG, van Eijck CHJ. Suker M, et al. EClinicalMedicine. 2019 Nov 19;17:100200. doi: 10.1016/j.eclinm.2019.10.013. eCollection 2019 Dec. EClinicalMedicine. 2019. PMID: 31891135 Free PMC article.
BACKGROUND: We conducted a multicentre phase II trial to investigate feasibility and antitumor activity of sequential FOLFIRINOX and Stereotactic Body Radiotherapy (SBRT) in patients with locally advanced pancreatic cancer (LAPC), (LAPC-1 trial). ...
BACKGROUND: We conducted a multicentre phase II trial to investigate feasibility and antitumor activity of sequential FOLFIRINOX and Ster …
Defining oligometastatic non-small cell lung cancer: A simulated multidisciplinary expert opinion.
Hendriks LEL, Dooms C, Berghmans T, Novello S, Levy A, De Ruysscher D, Hasan B, Giaj Levra M, Giaj Levra N, Besse B, Vansteenkiste J, Dingemans AC; European Organisation for Research and Treatment of Cancer (EORTC) Lung Cancer Group. Hendriks LEL, et al. Eur J Cancer. 2019 Dec;123:28-35. doi: 10.1016/j.ejca.2019.09.013. Epub 2019 Oct 23. Eur J Cancer. 2019. PMID: 31655358 Free article.
[Inter- and intrafraction imaging during stereotactic body radiation therapy: Which solutions for which tumours?].
Gensanne D, Hadj Henni A, Lauzin Y, Clarisse P, Thureau S. Gensanne D, et al. Cancer Radiother. 2019 Dec;23(8):891-895. doi: 10.1016/j.canrad.2019.09.001. Epub 2019 Oct 12. Cancer Radiother. 2019. PMID: 31615729 French.
Due to high dose gradients, stereotactic body radiation therapy requires high precision in the location of the tumour. ...Finally, propositions are given in terms of imaging system according to the location treated by stereotactic body radiation therapy....
Due to high dose gradients, stereotactic body radiation therapy requires high precision in the location of the tumour. ...Finally, pr …
A model-based patient selection tool to identify who may be at risk of exceeding dose tolerances during pancreatic SBRT.
Magallon-Baro A, Granton PV, Milder MTW, Loi M, Zolnay AG, Nuyttens JJ, Hoogeman MS. Magallon-Baro A, et al. Radiother Oncol. 2019 Dec;141:116-122. doi: 10.1016/j.radonc.2019.09.016. Epub 2019 Oct 9. Radiother Oncol. 2019. PMID: 31606227
PURPOSE: Locally advanced pancreatic cancer (LAPC) patients are prone to experience daily anatomical variations, which can lead to additional doses in organs-at-risk (OAR) during SBRT. ...
PURPOSE: Locally advanced pancreatic cancer (LAPC) patients are prone to experience daily anatomical variations, which can lead to ad …
Lymphocyte-sparing effect of stereotactic body radiation therapy compared to conventional fractionated radiation therapy in patients with locally advanced pancreatic cancer.
Wu G, Baine MJ, Zhao N, Li S, Li X, Lin C. Wu G, et al. BMC Cancer. 2019 Oct 22;19(1):977. doi: 10.1186/s12885-019-6220-1. BMC Cancer. 2019. PMID: 31640607 Free PMC article.
BACKGROUND: Conventionally fractionated (CF) radiation therapy (RT) has been associated with lymphopenia, leading to compromised overall survival (OS) in cancer patients. It currently remains unknown if stereotactic body (SB) RT induces lymphopenia to the same degree. The …
BACKGROUND: Conventionally fractionated (CF) radiation therapy (RT) has been associated with lymphopenia, leading to compromised overall sur …
Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.
Mills BN, Connolly KA, Ye J, Murphy JD, Uccello TP, Han BJ, Zhao T, Drage MG, Murthy A, Qiu H, Patel A, Figueroa NM, Johnston CJ, Prieto PA, Egilmez NK, Belt BA, Lord EM, Linehan DC, Gerber SA. Mills BN, et al. Cell Rep. 2019 Oct 8;29(2):406-421.e5. doi: 10.1016/j.celrep.2019.08.095. Cell Rep. 2019. PMID: 31597100 Free PMC article.
Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuvant approach for treating …
Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective …
Phase I/II Trial of Neoadjuvant Oregovomab-based Chemoimmunotherapy Followed by Stereotactic Body Radiotherapy and Nelfinavir For Locally Advanced Pancreatic Adenocarcinoma.
Lin C, Verma V, Lazenby A, Ly QP, Berim LD, Schwarz JK, Madiyalakan M, Nicodemus CF, Hollingsworth MA, Meza JL, Are C, Padussis J, Grem JL. Lin C, et al. Am J Clin Oncol. 2019 Oct;42(10):755-760. doi: 10.1097/COC.0000000000000599. Am J Clin Oncol. 2019. PMID: 31513018 Free PMC article. Clinical Trial.
OBJECTIVE: Cancer antigen (CA)-125 influences progression, metastasis, and outcomes in pancreatic cancer. This phase I/II trial (NCT01959672) evaluated the safety, efficacy, and immunologic correlates of chemoimmunotherapy (CIT) with oregovomab (anti-CA-125), followed by …
OBJECTIVE: Cancer antigen (CA)-125 influences progression, metastasis, and outcomes in pancreatic cancer. This phase I/II trial (NCT0 …
Feasibility of Using Hydrogel Spacers for Borderline-Resectable and Locally Advanced Pancreatic Tumors.
Kerdsirichairat T, Narang AK, Thompson E, Kim SH, Rao A, Ding K, Shin EJ. Kerdsirichairat T, et al. Gastroenterology. 2019 Oct;157(4):933-935. doi: 10.1053/j.gastro.2019.07.012. Epub 2019 Jul 12. Gastroenterology. 2019. PMID: 31306631 Free PMC article.
Learning Objective: Upon completion of this CME activity, successful learners will be able to describe the pharmacokinetics of hydrogel, identify appropriate candidates for hydrogel injection among patients with pancreatic cancer, and describe key techniques to successfull …
Learning Objective: Upon completion of this CME activity, successful learners will be able to describe the pharmacokinetics of hydrogel, ide …
Cancer metabolism in a snapshot: MRS(I).
Julià-Sapé M, Candiota AP, Arús C. Julià-Sapé M, et al. NMR Biomed. 2019 Oct;32(10):e4054. doi: 10.1002/nbm.4054. Epub 2019 Jan 11. NMR Biomed. 2019. PMID: 30633389 Review.
Hot-spots of, mostly, increased lactate dehydrogenase activity or flow between Pyr and lactate (Lac) have been seen with cancer progression in prostate (preclinical and in humans), brain and pancreas (both preclinical) tumours. Therapy response is usually signalled by decr …
Hot-spots of, mostly, increased lactate dehydrogenase activity or flow between Pyr and lactate (Lac) have been seen with cancer progression …
An 81-Year-Old Man With Shortness of Breath After Chemotherapy and Radiation Therapy for Lung Cancer.
Mehta AK, Khan Z, Deepak J. Mehta AK, et al. Chest. 2019 Sep;156(3):e63-e67. doi: 10.1016/j.chest.2019.04.091. Chest. 2019. PMID: 31511162
Medical history was pertinent for lung adenocarcinoma stage IIIb status post right upper lobectomy 10 years prior with recurrence of lung adenocarcinoma in the right lower lobe and was recently diagnosed with stage 1 primary pancreatic adenocarcinoma. He had been a longsta …
Medical history was pertinent for lung adenocarcinoma stage IIIb status post right upper lobectomy 10 years prior with recurrence of lung ad …
Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.
Palta M, Godfrey D, Goodman KA, Hoffe S, Dawson LA, Dessert D, Hall WA, Herman JM, Khorana AA, Merchant N, Parekh A, Patton C, Pepek JM, Salama JK, Tuli R, Koong AC. Palta M, et al. Pract Radiat Oncol. 2019 Sep-Oct;9(5):322-332. doi: 10.1016/j.prro.2019.06.016. Pract Radiat Oncol. 2019. PMID: 31474330
PURPOSE: This guideline systematically reviews the evidence for treatment of pancreatic cancer with radiation in the adjuvant, neoadjuvant, definitive, and palliative settings and provides recommendations on indications and technical considerations. ...RESULTS: The guideli …
PURPOSE: This guideline systematically reviews the evidence for treatment of pancreatic cancer with radiation in the adjuvant, neoadj …
Technological Advances in Surgical Equipment in Exotic Pet Medicine.
Chassang L, Bismuth C. Chassang L, et al. Vet Clin North Am Exot Anim Pract. 2019 Sep;22(3):471-487. doi: 10.1016/j.cvex.2019.05.005. Vet Clin North Am Exot Anim Pract. 2019. PMID: 31395326 Review.
These surgical equipment improve the simplicity, rapidity, and effectiveness of surgery. Vessel-sealing devices, radiosurgery, lasers, and ultrasound devices are commonly used because of their ease of use and increase in surgical efficiency. ...
These surgical equipment improve the simplicity, rapidity, and effectiveness of surgery. Vessel-sealing devices, radiosurgery, lasers …
The role of biological dose-escalation for pancreatic cancer.
Bruynzeel AME, Lagerwaard FJ. Bruynzeel AME, et al. Clin Transl Radiat Oncol. 2019 Apr 25;18:128-130. doi: 10.1016/j.ctro.2019.04.020. eCollection 2019 Sep. Clin Transl Radiat Oncol. 2019. PMID: 31341988 Free PMC article. Review.
The role of chemo-radiotherapy for treatment of locally advanced pancreatic cancer (LAPC) has been discussed for many years, and the absence of an overall survival benefit compared to gemcitabine chemotherapy alone in the recent LAP07 study seems to have increased t …
The role of chemo-radiotherapy for treatment of locally advanced pancreatic cancer (LAPC) has been discussed for many years, a …
Use of 4D-CT for radiotherapy planning and reality in France: Data from a national survey.
De Oliveira Duarte S, Rancoule C, He MY, Baury M, Sotton S, Vallard A, Espenel S, Guy JB, Guillaume É, Vial N, Magné N, Rehailia-Blanchard A. De Oliveira Duarte S, et al. Cancer Radiother. 2019 Sep;23(5):395-400. doi: 10.1016/j.canrad.2019.02.006. Epub 2019 Jul 19. Cancer Radiother. 2019. PMID: 31331842
METHODS AND MATERIAL: We conducted a survey in all French radiotherapy centres between March and April 2017. RESULTS: One hundred and seventy-two were contacted. ...Many centres declared they carried out several 4D-CT for treatment planning (29, 55% in case of stereotac …
METHODS AND MATERIAL: We conducted a survey in all French radiotherapy centres between March and April 2017. RESULTS: One hundred and …
Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non-Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial.
Theelen WSME, Peulen HMU, Lalezari F, van der Noort V, de Vries JF, Aerts JGJV, Dumoulin DW, Bahce I, Niemeijer AN, de Langen AJ, Monkhorst K, Baas P. Theelen WSME, et al. JAMA Oncol. 2019 Sep 1;5(9):1276-1282. doi: 10.1001/jamaoncol.2019.1478. JAMA Oncol. 2019. PMID: 31294749 Free PMC article.
This radiotherapy may enhance the effects of checkpoint inhibition. OBJECTIVE: To assess whether stereotactic body radiotherapy on a single tumor site preceding pembrolizumab treatment enhances tumor response in patients with metastatic NSCLC. ...CONCLUSIONS …
This radiotherapy may enhance the effects of checkpoint inhibition. OBJECTIVE: To assess whether stereotactic body radiothe …
Neoadjuvant stereotactic body radiation therapy for nonmetastatic pancreatic adenocarcinoma.
Jiang W, Haque W, Verma V, Butler EB, Teh BS. Jiang W, et al. Acta Oncol. 2019 Sep;58(9):1259-1266. doi: 10.1080/0284186X.2019.1631472. Epub 2019 Jun 25. Acta Oncol. 2019. PMID: 31237185
Neoadjuvant options include chemotherapy with/without radiotherapy. Stereotactic body radiation therapy (SBRT) is a novel radiation technique that may provide benefit over conventionally fractionated radiation therapy (CFRT) in the neoadjuvant setting. ...The chemo- …
Neoadjuvant options include chemotherapy with/without radiotherapy. Stereotactic body radiation therapy (SBRT) is a novel radi …
Stereotactic body radiotherapy as the initial treatment for hepatocellular carcinoma with extensive inferior vena cava and atrium tumor thrombus.
Shui Y, Zhu X, Wu J, Liang T, Wei Q. Shui Y, et al. Onco Targets Ther. 2019 Jul 4;12:5299-5303. doi: 10.2147/OTT.S208560. eCollection 2019. Onco Targets Ther. 2019. PMID: 31308700 Free PMC article.
A 49-year-old locally advanced HCC male with tumor thrombus extension into the IVC and the right atrium was successfully treated with stereotactic body radiotherapy (SBRT). A radiation dose of 40 Gy/5 fractions was delivered to the thrombus in 5 days. ...
A 49-year-old locally advanced HCC male with tumor thrombus extension into the IVC and the right atrium was successfully treated with ste …
Objective assessment of the effects of tumor motion in radiation therapy.
Ding Y, Barrett HH, Kupinski MA, Vinogradskiy Y, Miften M, Jones BL. Ding Y, et al. Med Phys. 2019 Jul;46(7):3311-3323. doi: 10.1002/mp.13601. Epub 2019 Jun 7. Med Phys. 2019. PMID: 31111961 Free PMC article.
We propose to use therapy operating characteristic (TOC) analysis to quantify the effects of motion on treatment efficacy for individual patients. We demonstrate the application of this tool with pancreatic stereotactic body radiation therapy (SBRT) clinical data an …
We propose to use therapy operating characteristic (TOC) analysis to quantify the effects of motion on treatment efficacy for individual pat …
Quantifying Allowable Motion to Achieve Safe Dose Escalation in Pancreatic SBRT.
Ding Y, Campbell WG, Miften M, Vinogradskiy Y, Goodman KA, Schefter T, Jones BL. Ding Y, et al. Pract Radiat Oncol. 2019 Jul-Aug;9(4):e432-e442. doi: 10.1016/j.prro.2019.03.006. Epub 2019 Apr 2. Pract Radiat Oncol. 2019. PMID: 30951868 Free PMC article.
PURPOSE: Tumor motion plays a key role in the safe delivery of stereotactic body radiation therapy (SBRT) for pancreatic cancer. The purpose of this study was to use tumor motion measured in patients to establish limits on motion magnitude for safe delivery of pa …
PURPOSE: Tumor motion plays a key role in the safe delivery of stereotactic body radiation therapy (SBRT) for pancreatic cance …
Radiotherapy of pancreatic cancer in older patients: A systematic review.
Ciabatti S, Cammelli S, Frakulli R, Arcelli A, Macchia G, Deodato F, Cilla S, Giaccherini L, Buwenge M, Morganti AG. Ciabatti S, et al. J Geriatr Oncol. 2019 Jul;10(4):534-539. doi: 10.1016/j.jgo.2018.09.007. Epub 2018 Sep 28. J Geriatr Oncol. 2019. PMID: 30270196
Pancreatic cancer (PaC) will soon be one of the main causes of cancer mortality. Furthermore, its incidence is higher in the older population and radiotherapy (RT) represents a treatment option. The aim of this review was to evaluate feasibility and outcome of RT in …
Pancreatic cancer (PaC) will soon be one of the main causes of cancer mortality. Furthermore, its incidence is higher in the older po …
Ablative radiation therapy for locally advanced pancreatic cancer: techniques and results.
Reyngold M, Parikh P, Crane CH. Reyngold M, et al. Radiat Oncol. 2019 Jun 6;14(1):95. doi: 10.1186/s13014-019-1309-x. Radiat Oncol. 2019. PMID: 31171025 Free PMC article. Review.
Standard doses of conventionally fractionated radiation have had minimal to no impact on the survival duration of patients with locally advanced unresectable pancreatic cancer (LAPC). The use of low-dose stereotactic body radiation (SBRT) in 3- to 5-fractionshas thu …
Standard doses of conventionally fractionated radiation have had minimal to no impact on the survival duration of patients with locally adva …
Endoscopic ultrasound-guided fiducial placement in pancreatic tumors: safety and technical feasibility.
Tabernero S, Prados S, Rubio MDC, de la Morena F, López M, Sánchez E. Tabernero S, et al. Rev Esp Enferm Dig. 2019 Jun;111(6):425-430. doi: 10.17235/reed.2019.5873/2018. Rev Esp Enferm Dig. 2019. PMID: 31081670 Free article.
BACKGROUND AND AIMS: stereotactic body radiation therapy (SBRT) for pancreatic malignancies requires the placement of fiducials to guide treatment delivery. The aim of this study was to assess the safety and feasibility of endoscopic ultrasound (EUS) guided fiducial …
BACKGROUND AND AIMS: stereotactic body radiation therapy (SBRT) for pancreatic malignancies requires the placement of fiducial …
Nowadays pancreatic cancer prognosis.
Jiménez Gordo AM, López Gómez M. Jiménez Gordo AM, et al. Med Clin (Barc). 2019 May 17;152(10):395-396. doi: 10.1016/j.medcli.2018.12.005. Epub 2019 Feb 2. Med Clin (Barc). 2019. PMID: 30718002 Review. English, Spanish. No abstract available.
Pancreatic cancer treated with SBRT: Effect of anatomical interfraction variations on dose to organs at risk.
Loi M, Magallon-Baro A, Suker M, van Eijck C, Sharma A, Hoogeman M, Nuyttens J. Loi M, et al. Radiother Oncol. 2019 May;134:67-73. doi: 10.1016/j.radonc.2019.01.020. Epub 2019 Feb 2. Radiother Oncol. 2019. PMID: 31005226
BACKGROUND AND PURPOSE: Interfraction shape and position variations of organs at risk (OARs) may increase uncertainty in dose delivery during stereotactic body radiotherapy (SBRT), potentially leading to overirradiation or concessions in planned tumor dose and/or co …
BACKGROUND AND PURPOSE: Interfraction shape and position variations of organs at risk (OARs) may increase uncertainty in dose delivery durin …
Modeling daily changes in organ-at-risk anatomy in a cohort of pancreatic cancer patients.
Magallon-Baro A, Loi M, Milder MTW, Granton PV, Zolnay AG, Nuyttens JJ, Hoogeman MS. Magallon-Baro A, et al. Radiother Oncol. 2019 May;134:127-134. doi: 10.1016/j.radonc.2019.01.030. Epub 2019 Feb 8. Radiother Oncol. 2019. PMID: 31005206
PURPOSE: To characterize daily geometrical variations of gastrointestinal organs with respect to pancreatic tumors, through a population-based statistical model. MATERIALS AND METHODS: The study included 131 CT scans from 35 pancreatic cancer patients treated with …
PURPOSE: To characterize daily geometrical variations of gastrointestinal organs with respect to pancreatic tumors, through a populat …
Using adaptive magnetic resonance image-guided radiation therapy for treatment of inoperable pancreatic cancer.
Rudra S, Jiang N, Rosenberg SA, Olsen JR, Roach MC, Wan L, Portelance L, Mellon EA, Bruynzeel A, Lagerwaard F, Bassetti MF, Parikh PJ, Lee PP. Rudra S, et al. Cancer Med. 2019 May;8(5):2123-2132. doi: 10.1002/cam4.2100. Epub 2019 Apr 1. Cancer Med. 2019. PMID: 30932367 Free PMC article.
METHODS: We reviewed 44 patients with inoperable pancreatic cancer treated with MRgRT. Treatments included conventional fractionation, hypofractionation, and stereotactic body radiation therapy. ...Prospective evaluation of high-dose RT regimens with standardized tr …
METHODS: We reviewed 44 patients with inoperable pancreatic cancer treated with MRgRT. Treatments included conventional fractionation …
Patterns of Local Failure After Stereotactic Body Radiation Therapy and Sequential Chemotherapy as Initial Treatment for Pancreatic Cancer: Implications of Target Volume Design.
Zhu X, Ju X, Cao Y, Shen Y, Cao F, Qing S, Fang F, Jia Z, Zhang H. Zhu X, et al. Int J Radiat Oncol Biol Phys. 2019 May 1;104(1):101-110. doi: 10.1016/j.ijrobp.2019.01.075. Epub 2019 Jan 23. Int J Radiat Oncol Biol Phys. 2019. PMID: 30684663
PURPOSE: To identify patterns of local failure in patients with pancreatic cancer receiving stereotactic body radiation therapy plus chemotherapy as initial treatment, for the optimal design of target volumes encompassing a majority of local recurrences. METHODS AND …
PURPOSE: To identify patterns of local failure in patients with pancreatic cancer receiving stereotactic body radiation therap …
Stereotactic body radiation therapy for locally advanced pancreatic cancer.
Jung J, Yoon SM, Park JH, Seo DW, Lee SS, Kim MH, Lee SK, Park DH, Song TJ, Ryoo BY, Chang HM, Kim KP, Yoo C, Jeong JH, Kim SC, Hwang DW, Lee JH, Song KB, Jo YY, Park J, Kim JH. Jung J, et al. PLoS One. 2019 Apr 12;14(4):e0214970. doi: 10.1371/journal.pone.0214970. eCollection 2019. PLoS One. 2019. PMID: 30978229 Free PMC article.
PURPOSE: Stereotactic body radiation therapy (SBRT) is a promising treatment modality for locally advanced pancreatic cancer (LAPC). ...RESULTS: A total of 95 patients with LAPC were analyzed, 52 of which (54.7%) had pancreatic head cancers. Most (94.7%) had …
PURPOSE: Stereotactic body radiation therapy (SBRT) is a promising treatment modality for locally advanced pancreatic cancer ( …
Comparisons of different neoadjuvant chemotherapy regimens with or without stereotactic body radiation therapy for borderline resectable pancreatic cancer: study protocol of a prospective, randomized phase II trial (BRPCNCC-1).
Gao S, Zhu X, Shi X, Cao K, Bian Y, Jiang H, Wang K, Guo S, Zhang H, Jin G. Gao S, et al. Radiat Oncol. 2019 Mar 27;14(1):52. doi: 10.1186/s13014-019-1254-8. Radiat Oncol. 2019. PMID: 30917842 Free PMC article. Clinical Trial.
Moreover, most of previous studies only adopted conventional radiotherapy as the neoadjuvant modality though stereotactic body radiation therapy (SBRT) has been proven effective and commonly employed in pancreatic cancer. ...Surgical resection will be perform …
Moreover, most of previous studies only adopted conventional radiotherapy as the neoadjuvant modality though stereotactic body …
Prognostic values of 18F-FDG PET/CT metabolic parameters and clinical figures in locally advanced pancreatic cancer underwent chemotherapy combined with stereotactic body radiation therapy.
Zhang A, Ren S, Yuan Y, Li X, Zhu X, Jiang L, Li D, Zuo C. Zhang A, et al. Medicine (Baltimore). 2019 Mar;98(13):e15064. doi: 10.1097/MD.0000000000015064. Medicine (Baltimore). 2019. PMID: 30921238 Free PMC article.
Stereotactic body radiation therapy (SBRT) has emerged to be a preference treatment for locally advanced pancreatic cancer (LAPC) patients. ...
Stereotactic body radiation therapy (SBRT) has emerged to be a preference treatment for locally advanced pancreatic cancer (LA …
Phase I trial of concurrent stereotactic body radiotherapy and nelfinavir for locally advanced borderline or unresectable pancreatic adenocarcinoma.
Lin C, Verma V, Ly QP, Lazenby A, Sasson A, Schwarz JK, Meza JL, Are C, Li S, Wang S, Hahn SM, Grem JL. Lin C, et al. Radiother Oncol. 2019 Mar;132:55-62. doi: 10.1016/j.radonc.2018.11.002. Epub 2018 Dec 20. Radiother Oncol. 2019. PMID: 30825970 Free PMC article. Clinical Trial.
INTRODUCTION: The HIV protease inhibitor nelfinavir (NFV) displays notable radiosensitizing effects. There have been no studies evaluating combined stereotactic body radiotherapy (SBRT) and NFV for borderline/unresectable pancreatic cancer. ...CONCLUSIONS: Co …
INTRODUCTION: The HIV protease inhibitor nelfinavir (NFV) displays notable radiosensitizing effects. There have been no studies evaluating c …
Pattern of Marginal Local Failure in a Phase II Trial of Neoadjuvant Chemotherapy and Stereotactic Body Radiation Therapy for Resectable and Borderline Resectable Pancreas Cancer.
Kharofa J, Mierzwa M, Olowokure O, Sussman J, Latif T, Gupta A, Xie C, Patel S, Esslinger H, Mcgill B, Wolf E, Ahmad SA. Kharofa J, et al. Am J Clin Oncol. 2019 Mar;42(3):247-252. doi: 10.1097/COC.0000000000000518. Am J Clin Oncol. 2019. PMID: 30724781 Clinical Trial.
OBJECTIVES: The main objectives of this study were to prospectively evaluate the safety and efficacy of stereotactic body radiation therapy (SBRT) in the neoadjuvant setting for resectable or borderline resectable pancreatic cancer. ...
OBJECTIVES: The main objectives of this study were to prospectively evaluate the safety and efficacy of stereotactic body radiation t …
Advanced Pancreatic Cancer: High-Intensity Focused Ultrasound (HIFU) and Other Local Ablative Therapies.
Marinova M, Wilhelm-Buchstab T, Strunk H. Marinova M, et al. Rofo. 2019 Mar;191(3):216-227. doi: 10.1055/a-0820-5564. Epub 2019 Jan 31. Rofo. 2019. PMID: 30703824 Free article. Review. English, German.
BACKGROUND: Locally advanced pancreatic cancer is a life-limiting tumor with a wide range of incapacitating symptoms such as cancer-associated pain. ...METHOD: Our experiences with HIFU treatment are based on 89 pancreatic cancer patients (UICC III-IV). Outcomes suc …
BACKGROUND: Locally advanced pancreatic cancer is a life-limiting tumor with a wide range of incapacitating symptoms such as cancer-a …
Application of stereotactic body radiotherapy in advanced pancreatic cancers in Australia.
Kim L, Nguyen N, Singhal N, Phan VA, Iankov I, Le H. Kim L, et al. J Med Radiat Sci. 2019 Mar;66(1):54-61. doi: 10.1002/jmrs.313. Epub 2018 Nov 9. J Med Radiat Sci. 2019. PMID: 30411540 Free PMC article. Clinical Trial.
INTRODUCTION: The majority of pancreatic cancers present locally advanced and carry a high mortality rate. ...Stereotactic body radiotherapy (SBRT) allows delivery of higher biologically equivalent dose in a shorter treatment duration. ...
INTRODUCTION: The majority of pancreatic cancers present locally advanced and carry a high mortality rate. ...Stereotactic bod …
Elective nodal irradiation with simultaneous integrated boost stereotactic body radiotherapy for pancreatic cancer: Analyses of planning feasibility and geometrically driven DVH prediction model.
Nakamura A, Prichard HA, Wo JY, Wolfgang JA, Hong TS. Nakamura A, et al. J Appl Clin Med Phys. 2019 Feb;20(2):71-83. doi: 10.1002/acm2.12528. Epub 2019 Jan 13. J Appl Clin Med Phys. 2019. PMID: 30636367 Free PMC article. Clinical Trial.
PURPOSE: We evaluate the feasibility of the elective nodal irradiation strategy in stereotactic body radiotherapy (SBRT) for pancreatic cancer. METHODS: Three simultaneous integrated boost (SIB)-SBRT plans (Boost1, Boost2, and Boost3) were retrospectively gen …
PURPOSE: We evaluate the feasibility of the elective nodal irradiation strategy in stereotactic body radiotherapy (SBRT) for …
Computed tomography based radiomic signature as predictive of survival and local control after stereotactic body radiation therapy in pancreatic carcinoma.
Cozzi L, Comito T, Fogliata A, Franzese C, Franceschini D, Bonifacio C, Tozzi A, Di Brina L, Clerici E, Tomatis S, Reggiori G, Lobefalo F, Stravato A, Mancosu P, Zerbi A, Sollini M, Kirienko M, Chiti A, Scorsetti M. Cozzi L, et al. PLoS One. 2019 Jan 18;14(1):e0210758. doi: 10.1371/journal.pone.0210758. eCollection 2019. PLoS One. 2019. PMID: 30657785 Free PMC article.
PURPOSE: To appraise the ability of a radiomics signature to predict clinical outcome after stereotactic body radiation therapy (SBRT) for pancreas carcinoma. METHODS: A cohort of 100 patients was included in this retrospective, single institution analysis. ...
PURPOSE: To appraise the ability of a radiomics signature to predict clinical outcome after stereotactic body radiation therapy (SBRT …
Pancreatic Adenocarcinoma: Epidemiology, Role of EUS in Diagnosis, Role of ERCP, Endoscopic Palliation.
Zar S, Kohoutová D, Bureš J. Zar S, et al. Acta Medica (Hradec Kralove). 2019;62(4):131-136. doi: 10.14712/18059694.2020.1. Acta Medica (Hradec Kralove). 2019. PMID: 32036844 Free article. Review.
Pancreatic cancer is the seventh leading cause of cancer deaths worldwide and is associated with a poor survival rate. ...Emerging EUS-guided therapeutic techniques have opened up new horizons in the management of pancreatic malignancy. EUS guidance can be used for …
Pancreatic cancer is the seventh leading cause of cancer deaths worldwide and is associated with a poor survival rate. ...Emerging EU …
The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic Cancer.
Ghaly M, Gogineni E, Saif MW. Ghaly M, et al. Pancreas (Fairfax). 2019;3(1):9-14. doi: 10.17140/POJ-3-110. Epub 2019 Nov 6. Pancreas (Fairfax). 2019. PMID: 31930185 Free PMC article.
Pancreatic cancer remains a devastating disease with dismal outcomes despite the development of novel chemotherapeutic regimens and radiation techniques. Stereotactic body radiation therapy (SBRT) offers an advantage both in image guidance and radiation dose deliver …
Pancreatic cancer remains a devastating disease with dismal outcomes despite the development of novel chemotherapeutic regimens and r …
A Collimator Setting Optimization Algorithm for Dual-Arc Volumetric Modulated Arc Therapy in Pancreas Stereotactic Body Radiation Therapy.
Li X, Wu J, Palta M, Zhang Y, Sheng Y, Zhang J, Wang C. Li X, et al. Technol Cancer Res Treat. 2019 Jan 1;18:1533033819870767. doi: 10.1177/1533033819870767. Technol Cancer Res Treat. 2019. PMID: 31426721 Free PMC article.
PURPOSE: To optimize collimator setting to improve dosimetric quality of pancreas volumetric modulated arc therapy plan for stereotactic body radiation therapy. ...CONCLUSIONS: The proposed collimator settings optimization algorithm successfully improved dosimetric …
PURPOSE: To optimize collimator setting to improve dosimetric quality of pancreas volumetric modulated arc therapy plan for stereo …
Technical Assessment of an Automated Treatment Planning on Dose Escalation of Pancreas Stereotactic Body Radiotherapy.
Wang S, Zheng D, Lin C, Lei Y, Verma V, Smith A, Ma R, Enke CA, Zhou S. Wang S, et al. Technol Cancer Res Treat. 2019 Jan 1;18:1533033819851520. doi: 10.1177/1533033819851520. Technol Cancer Res Treat. 2019. PMID: 31195891 Free PMC article.
BACKGROUND: Stereotactic body radiotherapy has been suggested to provide high rates of local control for locally advanced pancreatic cancer. ...METHODS: Twenty-four patients with pancreatic cancer treated with stereotactic body radiotherapy …
BACKGROUND: Stereotactic body radiotherapy has been suggested to provide high rates of local control for locally advanced p …
Stereotactic Body Radiotherapy - Current Indications.
Burkoň P, Slavik M, Kazda T, Pospíšil P, Prochazka T, Vrzal M, Šlampa P. Burkoň P, et al. Klin Onkol. 2019 Winter;32(1):10-24. doi: 10.14735/amko201910. Klin Onkol. 2019. PMID: 30894002 Review. English.
BACKGROUND: Stereotactic body radiotherapy (SBRT) is used to treat localized tumor lesions and consists of applying high doses of radiation to a small number of fractions using specially equipped linear accelerators, modern immobilization devices, and imaging method …
BACKGROUND: Stereotactic body radiotherapy (SBRT) is used to treat localized tumor lesions and consists of applying high doses …
Incidence and Patterns of Locoregional Failure After Stereotactic Body Radiation Therapy for Pancreatic Adenocarcinoma.
Baine MJ, Sleightholm R, Lin C. Baine MJ, et al. Pract Radiat Oncol. 2019 Jan;9(1):e29-e37. doi: 10.1016/j.prro.2018.06.006. Epub 2018 Jul 3. Pract Radiat Oncol. 2019. PMID: 30612720
PURPOSE: Stereotactic body radiation therapy (SBRT) is increasingly utilized in the neoadjuvant and definitive settings for pancreatic adenocarcinoma. ...METHODS AND MATERIALS: Electronic medical records of all patients treated in our department with SBRT for pan …
PURPOSE: Stereotactic body radiation therapy (SBRT) is increasingly utilized in the neoadjuvant and definitive settings for pancre …
Dosimetric Benefits and Practical Pitfalls of Daily Online Adaptive MRI-Guided Stereotactic Radiation Therapy for Pancreatic Cancer.
El-Bared N, Portelance L, Spieler BO, Kwon D, Padgett KR, Brown KM, Mellon EA. El-Bared N, et al. Pract Radiat Oncol. 2019 Jan;9(1):e46-e54. doi: 10.1016/j.prro.2018.08.010. Epub 2018 Aug 25. Pract Radiat Oncol. 2019. PMID: 30149192
We hypothesized that MRI-g OART would improve OAR sparing and target coverage in patients with pancreatic cancer treated with stereotactic body radiation therapy (SBRT). ...CONCLUSIONS: MRI-g OART improves target coverage and OAR sparing for pancreas SBRT. Th …
We hypothesized that MRI-g OART would improve OAR sparing and target coverage in patients with pancreatic cancer treated with ster …
The Clinical and Dosimetric Impact of Real-Time Target Tracking in Pancreatic SBRT.
Vinogradskiy Y, Goodman KA, Schefter T, Miften M, Jones BL. Vinogradskiy Y, et al. Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):268-275. doi: 10.1016/j.ijrobp.2018.08.021. Epub 2018 Aug 24. Int J Radiat Oncol Biol Phys. 2019. PMID: 30145394 Free PMC article.
In this study, we report on a large, retrospective cohort of pancreatic patients treated with real-time, fiducial-based, kV-image guidance of stereotactic body radiation therapy (SBRT). ...The increased accuracy of real-time target tracking may potentially enable sa …
In this study, we report on a large, retrospective cohort of pancreatic patients treated with real-time, fiducial-based, kV-image gui …
Dose Escalation in Stereotactic Body Radiation Therapy for Pancreatic Cancer: A Meta-Analysis.
Zaorsky NG, Lehrer EJ, Handorf E, Meyer JE. Zaorsky NG, et al. Am J Clin Oncol. 2019 Jan;42(1):46-55. doi: 10.1097/COC.0000000000000472. Am J Clin Oncol. 2019. PMID: 29965809
OBJECTIVE: To determine whether increasing biologically effective dose (BED) with stereotactic body radiation therapy (SBRT) is associated with improved local control (LC) or toxicities in patients with locally advanced pancreatic cancer. ...There were no significan …
OBJECTIVE: To determine whether increasing biologically effective dose (BED) with stereotactic body radiation therapy (SBRT) is assoc …
Large database utilization in health outcomes research in pancreatic cancer: an update.
Torgeson A, Tao R, Garrido-Laguna I, Willen B, Dursteler A, Lloyd S. Torgeson A, et al. J Gastrointest Oncol. 2018 Dec;9(6):996-1004. doi: 10.21037/jgo.2018.05.15. J Gastrointest Oncol. 2018. PMID: 30603118 Free PMC article. Review.
Multiple database studies have been published regarding the role for radiotherapy in resected pancreatic cancer (n=6), the timing of additional therapy in resectable pancreatic cancer (n=4), and the role for radiotherapy and resection in locally advanc …
Multiple database studies have been published regarding the role for radiotherapy in resected pancreatic cancer (n=6), the tim …
CyberKnife MLC-based treatment planning for abdominal and pelvic SBRT: Analysis of multiple dosimetric parameters, overall scoring index and clinical scoring.
Masi L, Zani M, Doro R, Calusi S, Di Cataldo V, Bonucci I, Cipressi S, Francolini G, Bonomo P, Livi L. Masi L, et al. Phys Med. 2018 Dec;56:25-33. doi: 10.1016/j.ejmp.2018.11.012. Epub 2018 Nov 21. Phys Med. 2018. PMID: 30527086
METHODS AND MATERIALS: Iris and MLC plans were created for 28 liver, 15 pancreas and 13 prostate cases including a wide range of PTV sizes (24-643 cm(3)). ...
METHODS AND MATERIALS: Iris and MLC plans were created for 28 liver, 15 pancreas and 13 prostate cases including a wide range of PTV …
Clinical assessment of palliative radiotherapy for pancreatic cancer.
Tian Q, Zhang F, Wang Y. Tian Q, et al. Cancer Radiother. 2018 Dec;22(8):778-783. doi: 10.1016/j.canrad.2018.02.004. Epub 2018 Nov 3. Cancer Radiother. 2018. PMID: 30401617 Clinical Trial.
PURPOSE: To evaluate the feasibility and response to radiotherapy for improving the symptoms and quality of life in patients with pancreatic cancer. ...CONCLUSIONS: Following treatment, pain and clinical symptoms were improved in a considerable proportion of patient …
PURPOSE: To evaluate the feasibility and response to radiotherapy for improving the symptoms and quality of life in patients with …
Dosimetric analysis of stereotactic rotational versus static intensity-modulated radiation therapy for pancreatic cancer.
Cho I, Park JW, Cho B, Kwak J, Yoon SM, Nesseler JP, Park J, Kim JH. Cho I, et al. Cancer Radiother. 2018 Dec;22(8):754-762. doi: 10.1016/j.canrad.2018.01.007. Epub 2018 Oct 12. Cancer Radiother. 2018. PMID: 30322818
PURPOSE: Stereotactic body radiation therapy is a promising treatment modality for locally advanced pancreatic cancer. ...Based on these results, volumetric-modulated arc therapy might be an appropriate treatment for locally advanced pancreatic cancer when co …
PURPOSE: Stereotactic body radiation therapy is a promising treatment modality for locally advanced pancreatic cancer. ...Base …
Predicting tumour motion during the whole radiotherapy treatment: a systematic approach for thoracic and abdominal lesions based on real time MR.
Cusumano D, Dhont J, Boldrini L, Chiloiro G, Teodoli S, Massaccesi M, Fionda B, Cellini F, Azario L, Vandemeulebroucke J, De Spirito M, Valentini V, Verellen D. Cusumano D, et al. Radiother Oncol. 2018 Dec;129(3):456-462. doi: 10.1016/j.radonc.2018.07.025. Epub 2018 Aug 22. Radiother Oncol. 2018. PMID: 30144955
Acquired resistance to immunotherapy in MMR-D pancreatic cancer.
Hu ZI, Hellmann MD, Wolchok JD, Vyas M, Shia J, Stadler ZK, Diaz LA Jr, O'Reilly EM. Hu ZI, et al. J Immunother Cancer. 2018 Nov 20;6(1):127. doi: 10.1186/s40425-018-0448-1. J Immunother Cancer. 2018. PMID: 30458888 Free PMC article.
BACKGROUND: MMR-D pancreatic cancer have been reported to respond to checkpoint inhibitor therapy. Here, we report the first case of acquired resistance to immunotherapy in MMR-D pancreatic cancer. CASE PRESENTATION: A 45-year-old woman with unresectable MMR-D pa …
BACKGROUND: MMR-D pancreatic cancer have been reported to respond to checkpoint inhibitor therapy. Here, we report the first case of …
MR-guided Gated Stereotactic Radiation Therapy Delivery for Lung, Adrenal, and Pancreatic Tumors: A Geometric Analysis.
van Sörnsen de Koste JR, Palacios MA, Bruynzeel AME, Slotman BJ, Senan S, Lagerwaard FJ. van Sörnsen de Koste JR, et al. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):858-866. doi: 10.1016/j.ijrobp.2018.05.048. Epub 2018 May 29. Int J Radiat Oncol Biol Phys. 2018. PMID: 30061007
PURPOSE: We implemented magnetic resonance-guided breath-hold stereotactic body radiation therapy in combination with visual feedback using the MRIdian system. ...The beam-off latency had a marginal impact on the GTV coverage. CONCLUSIONS: Gated stereotactic body ra …
PURPOSE: We implemented magnetic resonance-guided breath-hold stereotactic body radiation therapy in combination with visual feedback …
Prediction of overall survival after re-irradiation with stereotactic body radiation therapy for pancreatic cancer with a novel prognostic model (the SCAD score).
Zhu X, Li F, Ju X, Shen Y, Cao Y, Cao F, Fang F, Qing S, Jia Z, Zhang H. Zhu X, et al. Radiother Oncol. 2018 Nov;129(2):313-318. doi: 10.1016/j.radonc.2018.08.012. Epub 2018 Sep 11. Radiother Oncol. 2018. PMID: 30217337 Clinical Trial.
PURPOSE: To develop a predictive model for stratification of patients with pancreatic cancer who may achieve survival benefits from re-irradiation with stereotactic body radiation therapy (SBRT). ...
PURPOSE: To develop a predictive model for stratification of patients with pancreatic cancer who may achieve survival benefits from r …
Retrospective evaluation of decision-making for pancreatic stereotactic MR-guided adaptive radiotherapy.
Tyran M, Jiang N, Cao M, Raldow A, Lamb JM, Low D, Luterstein E, Steinberg ML, Lee P. Tyran M, et al. Radiother Oncol. 2018 Nov;129(2):319-325. doi: 10.1016/j.radonc.2018.08.009. Epub 2018 Aug 30. Radiother Oncol. 2018. PMID: 30174107
BACKGROUND/PURPOSE: Stereotactic-magnetic-resonance-guided-online-adaptive-radiotherapy (SMART) is a promising tool for pancreas stereotactic-body-radiotherapy. Our online-adaptive-radiotherapy (On-ART) process relies on daily image overv …
BACKGROUND/PURPOSE: Stereotactic-magnetic-resonance-guided-online-adaptive-radiotherapy (SMART) is a promising tool for pan …
MRI guided stereotactic radiotherapy for locally advanced pancreatic cancer.
Heerkens HD, van Vulpen M, Erickson B, Reerink O, Intven MP, van den Berg CA, Molenaar IQ, Vleggaar FP, Meijer GJ. Heerkens HD, et al. Br J Radiol. 2018 Nov;91(1091):20170563. doi: 10.1259/bjr.20170563. Epub 2018 Jul 31. Br J Radiol. 2018. PMID: 30063383 Free PMC article. Clinical Trial.
OBJECTIVE: We want to explore the safety and technical feasibility of MRI-guided stereotactic radiotherapy for locally advanced pancreatic cancer. METHODS: A custom-made abdominal corset was manufactured to reduce breathing induced tumour motion. ...No Grade3 …
OBJECTIVE: We want to explore the safety and technical feasibility of MRI-guided stereotactic radiotherapy for locally advance …
Dose Prediction Model for Duodenum Sparing With a Biodegradable Hydrogel Spacer for Pancreatic Cancer Radiation Therapy.
Feng Z, Rao AD, Cheng Z, Shin EJ, Moore J, Su L, Kim SH, Wong J, Narang A, Herman JM, McNutt T, Li D, Ding K. Feng Z, et al. Int J Radiat Oncol Biol Phys. 2018 Nov 1;102(3):651-659. doi: 10.1016/j.ijrobp.2018.07.184. Epub 2018 Jul 19. Int J Radiat Oncol Biol Phys. 2018. PMID: 30031143 Free PMC article.
METHODS AND MATERIALS: OVH metrics for the duodenum were collected from the stereotactic body radiation therapy plans of 232 patients with unresectable pancreatic cancer (33 Gy in 5 fractions). ...CONCLUSION: Our model may predict which patients require placement of …
METHODS AND MATERIALS: OVH metrics for the duodenum were collected from the stereotactic body radiation therapy plans of 232 patients …
The emerging role of stereotactic radiotherapy in gastrointestinal malignancies: a review of the literature and analysis from the Irish perspective.
O'Sullivan S, Cagney DN. O'Sullivan S, et al. Ir J Med Sci. 2018 Nov;187(4):887-894. doi: 10.1007/s11845-018-1755-8. Epub 2018 Feb 8. Ir J Med Sci. 2018. PMID: 29423821 Review.
Primary and secondary malignancies of the liver and pancreas result in significant morbidity and mortality, with increasing incidence and increasing demands on health services worldwide. ...Unfortunately, up to 80% of the patients present with unresectable disease, and so, …
Primary and secondary malignancies of the liver and pancreas result in significant morbidity and mortality, with increasing incidence …
The radiobiological impact of motion tracking of liver, pancreas and kidney SBRT tumors in a MR-linac.
Al-Ward S, Wronski M, Ahmad SB, Myrehaug S, Chu W, Sahgal A, Keller BM. Al-Ward S, et al. Phys Med Biol. 2018 Oct 30;63(21):215022. doi: 10.1088/1361-6560/aae7fd. Phys Med Biol. 2018. PMID: 30375365
The purpose of this work is to evaluate and quantify the potential radiobiological advantages of tumor tracking using the MR-linac for three disease sites: liver, pancreas and kidney. From each disease site, three patients were selected and 4DCT data sets were used. ...The …
The purpose of this work is to evaluate and quantify the potential radiobiological advantages of tumor tracking using the MR-linac for three …
Health-related quality of life for gemcitabine and nab-paclitaxel plus radiotherapy versus gemcitabine and S-1 plus radiotherapy in patients with metastatic pancreatic cancer.
Zhu X, Li F, Shi D, Ju X, Cao Y, Shen Y, Cao F, Qing S, Fang F, Jia Z, Zhang H. Zhu X, et al. Cancer Manag Res. 2018 Oct 23;10:4805-4815. doi: 10.2147/CMAR.S166713. eCollection 2018. Cancer Manag Res. 2018. PMID: 30425574 Free PMC article.
PURPOSE: To compare the effects of gemcitabine and nab-paclitaxel (GT) plus stereotactic body radiation therapy (SBRT) or gemcitabine and S-1 (GS) plus SBRT on health-related quality of life (HRQOL) of metastatic pancreatic cancer. ...CONCLUSION: GS may achieve bett …
PURPOSE: To compare the effects of gemcitabine and nab-paclitaxel (GT) plus stereotactic body radiation therapy (SBRT) or gemcitabine …
Stereotactic ablative radiotherapy (SABR) as primary, adjuvant, consolidation and re-treatment option in pancreatic cancer: scope for dose escalation and lessons for toxicity.
Goldsmith C, Plowman PN, Green MM, Dale RG, Price PM. Goldsmith C, et al. Radiat Oncol. 2018 Oct 19;13(1):204. doi: 10.1186/s13014-018-1138-3. Radiat Oncol. 2018. PMID: 30340643 Free PMC article.
BACKGROUND: Stereotactic ablative radiotherapy (SABR) offers an alternative treatment for pancreatic cancer, with the potential for improved tumour control and reduced toxicity compared with conventional therapies. ...Comparator regimen LQ modelling analysis …
BACKGROUND: Stereotactic ablative radiotherapy (SABR) offers an alternative treatment for pancreatic cancer, with the p …
Stereotactic radiotherapy of pancreatic cancer: a systematic review on pain relief.
Buwenge M, Macchia G, Arcelli A, Frakulli R, Fuccio L, Guerri S, Grassi E, Cammelli S, Cellini F, Morganti AG. Buwenge M, et al. J Pain Res. 2018 Oct 4;11:2169-2178. doi: 10.2147/JPR.S167994. eCollection 2018. J Pain Res. 2018. PMID: 30323651 Free PMC article. Review.
Locally advanced pancreatic carcinoma (LAPC) has a poor prognosis and the purpose of treatment is survival prolongation and symptom palliation. Radiotherapy has been reported to reduce pain in LAPC. Stereotactic RT (SBRT) is considered as an emerging radio …
Locally advanced pancreatic carcinoma (LAPC) has a poor prognosis and the purpose of treatment is survival prolongation and symptom p …
MRI-based high-precision irradiation in an orthotopic pancreatic tumor mouse model : A treatment planning study.
Dobiasch S, Kampfer S, Habermehl D, Duma MN, Felix K, Strauss A, Schilling D, Wilkens JJ, Combs SE. Dobiasch S, et al. Strahlenther Onkol. 2018 Oct;194(10):944-952. doi: 10.1007/s00066-018-1326-y. Epub 2018 Jun 11. Strahlenther Onkol. 2018. PMID: 29947818 English.
Three irradiation techniques (rotational, 3D multifield, stereotactic) were performed with the SARRP system (Small Animal Radiation Research Platform, Xstrahl Ltd., Camberley, UK). ...CONCLUSION: An MRI/CT-based treatment planning for high-precision IGRT using different te …
Three irradiation techniques (rotational, 3D multifield, stereotactic) were performed with the SARRP system (Small Animal Radiation R …
Stereotactic body radiotherapy based treatment for hepatocellular carcinoma with extensive portal vein tumor thrombosis.
Shui Y, Yu W, Ren X, Guo Y, Xu J, Ma T, Zhang B, Wu J, Li Q, Hu Q, Shen L, Bai X, Liang T, Wei Q. Shui Y, et al. Radiat Oncol. 2018 Sep 25;13(1):188. doi: 10.1186/s13014-018-1136-5. Radiat Oncol. 2018. PMID: 30253783 Free PMC article.
BACKGROUND: There is currently no worldwide consensus for the management of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). We evaluated the efficacy of stereotactic body radiotherapy (SBRT) as the initial treatment for HCC with extensive PVTT …
BACKGROUND: There is currently no worldwide consensus for the management of hepatocellular carcinoma (HCC) with portal vein tumor thrombus ( …
Chemotherapy in combination with stereotactic body radiation therapy (SBRT) for oligometastatic pancreatic cancer.
Vorobyov N, Rykov I, Orlova R, Cherkashin M. Vorobyov N, et al. BMJ Case Rep. 2018 Sep 15;2018:bcr2018225846. doi: 10.1136/bcr-2018-225846. BMJ Case Rep. 2018. PMID: 30219780 Free PMC article.
Metastatic pancreatic cancer is characterised by poor prognosis. High toxicity of chemotherapy limits its use in elderly patients with severe comorbidities. ...Thereafter, consolidating radiosurgical treatment was performed. Dose to pancreatic and liver lesions was …
Metastatic pancreatic cancer is characterised by poor prognosis. High toxicity of chemotherapy limits its use in elderly patients wit …
Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer.
Yasmin-Karim S, Bruck PT, Moreau M, Kunjachan S, Chen GZ, Kumar R, Grabow S, Dougan SK, Ngwa W. Yasmin-Karim S, et al. Front Immunol. 2018 Sep 7;9:2030. doi: 10.3389/fimmu.2018.02030. eCollection 2018. Front Immunol. 2018. PMID: 30245691 Free PMC article.
In practice, this abscopal effect is rarely observed. We use two mouse models of pancreatic cancer to show that a single dose of stereotactic body radiation therapy (SBRT) synergizes with intratumoral injection of agonistic anti-CD40, resulting in regression of non- …
In practice, this abscopal effect is rarely observed. We use two mouse models of pancreatic cancer to show that a single dose of s …
Evaluation of delivered dose to a moving target by 4D dose reconstruction in gated volumetric modulated arc therapy.
Chung H, Jung J, Jeong C, Kwak J, Park JH, Kim SS, Yoon SM, Song SY, Kim JH, Choi EK, Cho S, Cho B. Chung H, et al. PLoS One. 2018 Sep 7;13(9):e0202765. doi: 10.1371/journal.pone.0202765. eCollection 2018. PLoS One. 2018. PMID: 30192793 Free PMC article.
MATERIALS AND METHODS: A total 112 treatment sessions of gated VMAT for 30 stereotactic body radiotherapy (SBRT) patients (10 lung, 10 liver, and 10 pancreas) were evaluated. ...The average gamma pass rates were 97.6 4.8% for lung cases, 99.6 0.5% for liver c …
MATERIALS AND METHODS: A total 112 treatment sessions of gated VMAT for 30 stereotactic body radiotherapy (SBRT) patients (10 …
Autoimmune Granulomatous Inflammation of Lacrimal Glands and Axonal Neuritis Following Treatment With Ipilimumab and Radiation Therapy.
Ileana Dumbrava E, Smith V, Alfattal R, El-Naggar AK, Penas-Prado M, Tsimberidou AM. Ileana Dumbrava E, et al. J Immunother. 2018 Sep;41(7):336-339. doi: 10.1097/CJI.0000000000000224. J Immunother. 2018. PMID: 29787423 Free PMC article.
The most notable immune reactions are noted in skin (rash), gastrointestinal track (colitis, hepatitis, pancreatitis), lung (pneumonitis), heart (myocarditis), and endocrine system (thyroiditis, hypophysitis). ...
The most notable immune reactions are noted in skin (rash), gastrointestinal track (colitis, hepatitis, pancreatitis), lung (pneumoni …
Dosimetric analysis of stereotactic body radiation therapy for pancreatic cancer using MR-guided Tri-(60)Co unit, MR-guided LINAC, and conventional LINAC-based plans.
Ramey SJ, Padgett KR, Lamichhane N, Neboori HJ, Kwon D, Mellon EA, Brown K, Duffy M, Victoria J, Dogan N, Portelance L. Ramey SJ, et al. Pract Radiat Oncol. 2018 Sep-Oct;8(5):e312-e321. doi: 10.1016/j.prro.2018.02.010. Epub 2018 Mar 1. Pract Radiat Oncol. 2018. PMID: 29703704 No abstract available.
Linac-based stereotactic body radiation therapy for unresectable locally advanced pancreatic cancer: risk-adapted dose prescription and image-guided delivery.
Mazzola R, Fersino S, Aiello D, Gregucci F, Tebano U, Corradini S, Di Paola G, Cirillo M, Tondulli L, Ruffo G, Ruggieri R, Alongi F. Mazzola R, et al. Strahlenther Onkol. 2018 Sep;194(9):835-842. doi: 10.1007/s00066-018-1306-2. Epub 2018 Apr 25. Strahlenther Onkol. 2018. PMID: 29696321 English.
BACKGROUND: Stereotactic body radiation therapy (SBRT) represents a new treatment option for locally advanced pancreatic cancer (LAPC). ...One-year LC and OS were 81% and 75%, respectively. A total of 12 patients (37%) had an extra-pancreatic progression. No …
BACKGROUND: Stereotactic body radiation therapy (SBRT) represents a new treatment option for locally advanced pancreatic cance …
Long-term complete response after transcatheter arterial chemoembolization and stereotactic body radiation therapy in a patient with hepatocellular carcinoma at the caudate lobe.
Chung YK, Hwang S, Ko GY, Yoon SM. Chung YK, et al. Ann Hepatobiliary Pancreat Surg. 2018 Aug;22(3):274-281. doi: 10.14701/ahbps.2018.22.3.274. Epub 2018 Aug 31. Ann Hepatobiliary Pancreat Surg. 2018. PMID: 30215050 Free PMC article.
It is expected that a combination of transcatheter arterial chemoembolization (TACE) with stereotactic body radiation therapy (SBRT) may induce synergistic therapeutic effects in hepatocellular carcinoma (HCC), which would result in a high rate of complete therapeutic resp …
It is expected that a combination of transcatheter arterial chemoembolization (TACE) with stereotactic body radiation therapy (SBRT) …
Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy.
Ng SP, Koay EJ. Ng SP, et al. Ann Pancreat Cancer. 2018 Aug;1:22. doi: 10.21037/apc.2018.07.03. Epub 2018 Aug 13. Ann Pancreat Cancer. 2018. PMID: 30198024 Free PMC article.
The role of radiotherapy for locally advanced pancreatic cancer (LAPC) is unclear based on studies that used conventional doses and fractionation schedules. Modern radiotherapy techniques have not been studied in depth, however. We reviewed the literature on …
The role of radiotherapy for locally advanced pancreatic cancer (LAPC) is unclear based on studies that used conventional dose …
Towards abdominal MRI-based treatment planning using population-based Hounsfield units for bulk density assignment.
Hsu SH, Zawisza I, O'Grady K, Peng Q, Tomé WA. Hsu SH, et al. Phys Med Biol. 2018 Jul 24;63(15):155003. doi: 10.1088/1361-6560/aacfb1. Phys Med Biol. 2018. PMID: 29952320
A retrospective study was performed utilizing 18 patients that had previously undergone stereotactic body radiation therapy for liver or pancreas cancer. HU values in the CT datasets were collected for various tissue types, and compared with the HUs derived from ICR …
A retrospective study was performed utilizing 18 patients that had previously undergone stereotactic body radiation therapy for liver …
Intraoperative Ultrasound Appearance of a Pancreatic Cerebral Metastasis: A Case Report.
Donofrio CA, Barzaghi LR, Capitanio JF, Cavalli A, Panni P, Snider S, Mortini P. Donofrio CA, et al. J Neurol Surg A Cent Eur Neurosurg. 2018 Jul;79(4):337-340. doi: 10.1055/s-0037-1608874. Epub 2018 Mar 23. J Neurol Surg A Cent Eur Neurosurg. 2018. PMID: 29571176
BACKGROUND: Brain metastases (BMs) derived from pancreatic adenocarcinoma (PAC) have an extremely low incidence (0.1-0.4%) and are usually associated with a very poor prognosis. The treatment strategy is palliative and includes conventional radiotherapy, stereota …
BACKGROUND: Brain metastases (BMs) derived from pancreatic adenocarcinoma (PAC) have an extremely low incidence (0.1-0.4%) and are us …
Is a Pathological Complete Response Following Neoadjuvant Chemoradiation Associated With Prolonged Survival in Patients With Pancreatic Cancer?
He J, Blair AB, Groot VP, Javed AA, Burkhart RA, Gemenetzis G, Hruban RH, Waters KM, Poling J, Zheng L, Laheru D, Herman JM, Makary MA, Weiss MJ, Cameron JL, Wolfgang CL. He J, et al. Ann Surg. 2018 Jul;268(1):1-8. doi: 10.1097/SLA.0000000000002672. Ann Surg. 2018. PMID: 29334562 Free PMC article.
OBJECTIVES: To describe the survival outcome of patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA-PDAC) who have a pathologic complete response (pCR) following neoadjuvant chemoradiation. ...RESULTS: One hundred eighty-six pati …
OBJECTIVES: To describe the survival outcome of patients with borderline resectable or locally advanced pancreatic ductal adenocarcin …
VHL-Associated Optic Nerve Hemangioblastoma Treated with Stereotactic Radiosurgery.
Kanno H, Osano S, Shinonaga M. Kanno H, et al. J Kidney Cancer VHL. 2018 Jun 6;5(2):1-6. doi: 10.15586/jkcvhl.2018.104. eCollection 2018. J Kidney Cancer VHL. 2018. PMID: 29911000 Free PMC article.
The optic nerve hemangioblastoma was treated with fractionated stereotactic radiosurgery using Novalis. Eighteen months after the stereotactic radiosurgery, the tumor volume decreased although the patient lost vision. This report presents an extremely …
The optic nerve hemangioblastoma was treated with fractionated stereotactic radiosurgery using Novalis. Eighteen months after …
SBRT for pancreatic cancer: In regard of Bohoudi et al.
Bohoudi O, Bruynzeel AM, Senan S, Cuijpers JP, Slotman BJ, Lagerwaard FJ, Palacios MA. Bohoudi O, et al. Radiother Oncol. 2018 Jun;127(3):511-512. doi: 10.1016/j.radonc.2018.04.024. Epub 2018 May 11. Radiother Oncol. 2018. PMID: 29759683 No abstract available.
SBRT for pancreatic cancer: In regard of Bohoudi et al.
Garibaldi C, Moretti E, Russo S, Talamonti C, Villaggi E, Mancosu P; Italian Medical Physicists SBRT Working Group. Garibaldi C, et al. Radiother Oncol. 2018 Jun;127(3):509-510. doi: 10.1016/j.radonc.2018.04.001. Epub 2018 May 3. Radiother Oncol. 2018. PMID: 29731159 No abstract available.
Five-Fraction Stereotactic Body Radiation Therapy (SBRT) and Chemotherapy for the Local Management of Metastatic Pancreatic Cancer.
Lischalk JW, Burke A, Chew J, Elledge C, Gurka M, Marshall J, Pishvaian M, Collins S, Unger K. Lischalk JW, et al. J Gastrointest Cancer. 2018 Jun;49(2):116-123. doi: 10.1007/s12029-016-9909-2. J Gastrointest Cancer. 2018. PMID: 28044263
BACKGROUND: The majority of patients with pancreatic cancer are diagnosed with metastatic disease at presentation. ...As a consequence, further exploration of effective methods of local control and palliation is essential. Stereotactic body radiation therapy (SBRT) …
BACKGROUND: The majority of patients with pancreatic cancer are diagnosed with metastatic disease at presentation. ...As a consequenc …
Postoperative complications after resection of borderline resectable and locally advanced pancreatic cancer: The impact of neoadjuvant chemotherapy with conventional radiation or stereotactic body radiation therapy.
Blair AB, Rosati LM, Rezaee N, Gemenetzis G, Zheng L, Hruban RH, Cameron JL, Weiss MJ, Wolfgang CL, Herman JM, He J. Blair AB, et al. Surgery. 2018 May;163(5):1090-1096. doi: 10.1016/j.surg.2017.11.027. Epub 2018 Mar 12. Surgery. 2018. PMID: 29395234 Free PMC article.
BACKGROUND: The impact of neoadjuvant stereotactic body radiation therapy on postoperative complications for patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma remains unclear. ...METHODS: Patients with borderline resectable or …
BACKGROUND: The impact of neoadjuvant stereotactic body radiation therapy on postoperative complications for patients with borderline …
Management of Borderline Resectable Pancreatic Cancer.
Toesca DAS, Koong AJ, Poultsides GA, Visser BC, Haraldsdottir S, Koong AC, Chang DT. Toesca DAS, et al. Int J Radiat Oncol Biol Phys. 2018 Apr 1;100(5):1155-1174. doi: 10.1016/j.ijrobp.2017.12.287. Int J Radiat Oncol Biol Phys. 2018. PMID: 29722658 Review.
With the rapid development of imaging modalities and surgical techniques, the clinical entity representing tumors that are intermediate between resectable and unresectable pancreatic adenocarcinoma has been identified has been termed "borderline resectable" (BR). ...This r …
With the rapid development of imaging modalities and surgical techniques, the clinical entity representing tumors that are intermediate betw …
Perioperative outcomes and survival following neoadjuvant stereotactic body radiation therapy (SBRT) versus intensity-modulated radiation therapy (IMRT) in pancreatic adenocarcinoma.
Chapman BC, Gleisner A, Rigg D, Meguid C, Goodman K, Brauer B, Gajdos C, Schulick RD, Edil BH, McCarter MD. Chapman BC, et al. J Surg Oncol. 2018 Apr;117(5):1073-1083. doi: 10.1002/jso.25004. Epub 2018 Feb 15. J Surg Oncol. 2018. PMID: 29448308
BACKGROUND AND OBJECTIVES: To compare outcomes in patients receiving neoadjuvant stereotactic body radiation therapy (SBRT) with those receiving intensity-modulated radiation therapy (IMRT) for pancreatic adenocarcinoma. METHODS: We analyzed patients receiving neoad …
BACKGROUND AND OBJECTIVES: To compare outcomes in patients receiving neoadjuvant stereotactic body radiation therapy (SBRT) with thos …
Chemotherapy with or Without Definitive Radiation Therapy in Inoperable Pancreatic Cancer.
Zhong J, Switchenko J, Behera M, Kooby D, Maithel SK, McDonald MW, Lin JY, Cassidy RJ, El-Rayes B, Landry J, Patel PR. Zhong J, et al. Ann Surg Oncol. 2018 Apr;25(4):1026-1033. doi: 10.1245/s10434-017-6322-4. Epub 2018 Jan 11. Ann Surg Oncol. 2018. PMID: 29327180 Free PMC article.
Patients undergoing definitive RT, defined as at least 20 fractions or 5 Gy per fraction [i.e., stereotactic body radiation therapy (SBRT)] were included in the CRT cohort. ...Definitive radiotherapy should remain a treatment option for LAPC, but optimal selection c …
Patients undergoing definitive RT, defined as at least 20 fractions or 5 Gy per fraction [i.e., stereotactic body radiation therapy ( …
Stereotactic body radiotherapy (SBRT) for patients with locally advanced pancreatic cancer: A single center experience.
Jumeau R, Delouya G, Roberge D, Donath D, Béliveau-Nadeau D, Campeau MP. Jumeau R, et al. Dig Liver Dis. 2018 Apr;50(4):396-400. doi: 10.1016/j.dld.2017.12.013. Epub 2017 Dec 21. Dig Liver Dis. 2018. PMID: 29326012
INTRODUCTION: Despite advances in treatment, notably in systemic therapy, the prognosis of pancreatic adenocarcinoma (PADC) remains dismal. Stereotactic body radiotherapy (SBRT) is an emerging tool in the complex management of PADC. ...CONCLUSION: In PADC, fr …
INTRODUCTION: Despite advances in treatment, notably in systemic therapy, the prognosis of pancreatic adenocarcinoma (PADC) remains d …
Stereotactic Magnetic Resonance-guided Online Adaptive Radiotherapy for Oligometastatic Breast Cancer: A Case Report.
Tyran M, Cao M, Raldow AC, Dang A, Lamb J, Low DA, Steinberg ML, Lee P. Tyran M, et al. Cureus. 2018 Mar 26;10(3):e2368. doi: 10.7759/cureus.2368. Cureus. 2018. PMID: 29805937 Free PMC article.
We present a case of durable local control achieved in a patient treated with stereotactic magnetic resonance-guided adaptive radiation therapy (SMART) for an abdominal lymph node in the setting of oligometastatic breast cancer. ...At 20 months after definitive treatment o …
We present a case of durable local control achieved in a patient treated with stereotactic magnetic resonance-guided adaptive radiati …
Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer.
Ng SP, Herman JM. Ng SP, et al. Cancers (Basel). 2018 Mar 16;10(3):75. doi: 10.3390/cancers10030075. Cancers (Basel). 2018. PMID: 29547526 Free PMC article. Review.
Stereotactic radiotherapy, which employs a hypofractionated regimen, has the potential advantage of delivering a high dose of radiation to the tumor in a short period of time (typically over 5 days) with minimal dose to the surrounding normal structures. ...This rev …
Stereotactic radiotherapy, which employs a hypofractionated regimen, has the potential advantage of delivering a high dose of …
Metastatic primary pulmonary melanoma successfully treated with checkpoint inhibitors.
Al-Helou G, Temesgen N, Gwizdala J, Ahari J. Al-Helou G, et al. BMJ Case Rep. 2018 Mar 15;2018:bcr2017223025. doi: 10.1136/bcr-2017-223025. BMJ Case Rep. 2018. PMID: 29545428 Free PMC article.
MRI revealed multiple brain lesions suspicious for metastases. Further workup revealed a 5 cm lung mass and a 1 cm pancreatic nodule. Biopsy of both pulmonary and pancreatic lesions was consistent with melanoma and was similar histologically. The patient underwent c …
MRI revealed multiple brain lesions suspicious for metastases. Further workup revealed a 5 cm lung mass and a 1 cm pancreatic nodule. …
Stereotactic MRI-guided Adaptive Radiation Therapy (SMART) for Locally Advanced Pancreatic Cancer: A Promising Approach.
Luterstein E, Cao M, Lamb J, Raldow AC, Low DA, Steinberg ML, Lee P. Luterstein E, et al. Cureus. 2018 Mar 14;10(3):e2324. doi: 10.7759/cureus.2324. Cureus. 2018. PMID: 29765792 Free PMC article.
Stereotactic body radiation therapy (SBRT), which has a shorter treatment course than conventionally fractionated radiotherapy and allows for better integration with systemic therapy, may confer a survival benefit but is limited by gastrointestinal toxicity. Ster …
Stereotactic body radiation therapy (SBRT), which has a shorter treatment course than conventionally fractionated radiotherapy …
Automatic patient positioning and gating window settings in respiratory-gated stereotactic body radiation therapy for pancreatic cancer using fluoroscopic imaging.
Pettersson N, Simpson D, Atwood T, Hattangadi-Gluth J, Murphy J, Cerviño L. Pettersson N, et al. J Appl Clin Med Phys. 2018 Mar;19(2):74-82. doi: 10.1002/acm2.12258. Epub 2018 Jan 27. J Appl Clin Med Phys. 2018. PMID: 29377561 Free PMC article.
We retrospectively compared clinically used setups to the automatic setups by our method in five pancreatic cancer patients treated with hypofractionated RT. In 15 investigated fractions, the average (standard deviation) differences between the clinical and automatic setup …
We retrospectively compared clinically used setups to the automatic setups by our method in five pancreatic cancer patients treated w …
Results of a prospective phase 2 clinical trial of induction gemcitabine/capecitabine followed by stereotactic ablative radiation therapy in borderline resectable or locally advanced pancreatic adenocarcinoma.
Quan K, Sutera P, Xu K, Bernard ME, Burton SA, Wegner RE, Zeh H, Bahary N, Stoller R, Heron DE. Quan K, et al. Pract Radiat Oncol. 2018 Mar-Apr;8(2):95-106. doi: 10.1016/j.prro.2017.10.001. Epub 2017 Oct 7. Pract Radiat Oncol. 2018. PMID: 29291966 Clinical Trial.
PURPOSE: Stereotactic ablative radiation therapy's (SABR's) great conformity and short duration has become an attractive treatment modality. ...Of those 32 patients, 34.3% (n = 12: 10 BR, 2 LA) underwent pancreaticoduodenectomy and 11 of 12 (91.7%) received R0 resec …
PURPOSE: Stereotactic ablative radiation therapy's (SABR's) great conformity and short duration has become an attractive treatment mo …
Essential role of radiation therapy for the treatment of pancreatic cancer : Novel study concepts and established treatment recommendations.
Dobiasch S, Goerig NL, Fietkau R, Combs SE. Dobiasch S, et al. Strahlenther Onkol. 2018 Mar;194(3):185-195. doi: 10.1007/s00066-017-1227-5. Epub 2017 Nov 1. Strahlenther Onkol. 2018. PMID: 29094172 Review. English.
BACKGROUND: Pancreatic cancer is one of the most aggressive human tumors and the incidence has increased over the last 6 years. ...The role of radiation therapy as treatment option for patients with pancreatic cancer is controversially discussed although radiation o …
BACKGROUND: Pancreatic cancer is one of the most aggressive human tumors and the incidence has increased over the last 6 years. ...Th …
Albumin and Neutrophil-Lymphocyte Ratio (NLR) Predict Survival in Patients With Pancreatic Adenocarcinoma Treated With SBRT.
Alagappan M, Pollom EL, von Eyben R, Kozak MM, Aggarwal S, Poultsides GA, Koong AC, Chang DT. Alagappan M, et al. Am J Clin Oncol. 2018 Mar;41(3):242-247. doi: 10.1097/COC.0000000000000263. Am J Clin Oncol. 2018. PMID: 26757436
PURPOSE: To determine if pretreatment nutritional status and inflammatory markers correlate with survival in patients with locally advanced pancreatic adenocarcinoma treated with stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: We retrospectively …
PURPOSE: To determine if pretreatment nutritional status and inflammatory markers correlate with survival in patients with locally advanced …
Pre-treatment DWI as a predictor of overall survival in locally advanced pancreatic cancer treated with Cyberknife radiotherapy and sequential S-1 therapy.
Zhang Y, Zhu X, Liu D, Song J, Zhang H, Lu J. Zhang Y, et al. Cancer Imaging. 2018 Feb 22;18(1):6. doi: 10.1186/s40644-018-0139-7. Cancer Imaging. 2018. PMID: 29471875 Free PMC article. Retracted.
BACKGROUND: To identify the value of the pre-treatment apparent diffusion coefficient (ADC) derived from diffusion weighted imaging (DWI) in predicting the overall survival (OS) for locally advanced pancreatic cancer (LAPC) treated with Cyberknife followed by sequential S- …
BACKGROUND: To identify the value of the pre-treatment apparent diffusion coefficient (ADC) derived from diffusion weighted imaging (DWI) in …
Stereotactic Body Radiotherapy (SBRT) for liver metastasis - clinical outcomes from the international multi-institutional RSSearch Patient Registry.
Mahadevan A, Blanck O, Lanciano R, Peddada A, Sundararaman S, D'Ambrosio D, Sharma S, Perry D, Kolker J, Davis J. Mahadevan A, et al. Radiat Oncol. 2018 Feb 13;13(1):26. doi: 10.1186/s13014-018-0969-2. Radiat Oncol. 2018. PMID: 29439707 Free PMC article.
BACKGROUND: Stereotactic body radiotherapy (SBRT) is an emerging treatment option for liver metastases in patients unsuitable for surgery. ...Median OS was greater for patients with CRC (27 mo), breast (21 mo) and gynecological (25 mo) metastases compared to lung (1 …
BACKGROUND: Stereotactic body radiotherapy (SBRT) is an emerging treatment option for liver metastases in patients unsuitable …
Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy.
Rao AD, Liu Y, von Eyben R, Hsu CC, Hu C, Rosati LM, Parekh A, Ng K, Hacker-Prietz A, Zheng L, Pawlik TM, Laheru DA, Jaffee EM, Weiss MJ, Le DT, Hruban RH, De Jesus-Acosta A, Wolfgang CL, Narang AK, Chang DT, Koong AC, Herman JM. Rao AD, et al. Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):486-489. doi: 10.1016/j.ijrobp.2017.10.001. Epub 2017 Oct 12. Int J Radiat Oncol Biol Phys. 2018. PMID: 29157747 Free PMC article.
PURPOSE: To explore seromarker levels for associations with outcomes in locally advanced pancreatic cancer (LAPC) patients who received chemotherapy and stereotactic body radiation therapy (SBRT). ...Proximity ligation assay quantified the expression levels of 36 …
PURPOSE: To explore seromarker levels for associations with outcomes in locally advanced pancreatic cancer (LAPC) patients who receiv …
The role of imaging in the clinical practice of radiation oncology for pancreatic cancer.
Koay EJ, Hall W, Park PC, Erickson B, Herman JM. Koay EJ, et al. Abdom Radiol (NY). 2018 Feb;43(2):393-403. doi: 10.1007/s00261-017-1373-3. Abdom Radiol (NY). 2018. PMID: 29110053 Free PMC article. Review.
Advances in technology have enabled the delivery of high doses of radiation therapy for pancreatic ductal adenocarcinoma (PDAC) with low rates of toxicity. Although the role of radiation for pancreatic cancer continues to evolve, encouraging results with newer techn …
Advances in technology have enabled the delivery of high doses of radiation therapy for pancreatic ductal adenocarcinoma (PDAC) with …
Resection of Locally Advanced Pancreatic Cancer without Regression of Arterial Encasement After Modern-Era Neoadjuvant Therapy.
Kluger MD, Rashid MF, Rosario VL, Schrope BA, Steinman JA, Hecht EM, Chabot JA. Kluger MD, et al. J Gastrointest Surg. 2018 Feb;22(2):235-241. doi: 10.1007/s11605-017-3556-1. Epub 2017 Sep 11. J Gastrointest Surg. 2018. PMID: 28895032
METHODS: Sixty-one LAPC patients were brought to the operating room after neoadjuvant therapy for NCCN-defined unresectable pancreatic cancer between 2012 and 2017. Pts were explored with intent of pancreatectomy and irreversible electroporation for margin extension …
METHODS: Sixty-one LAPC patients were brought to the operating room after neoadjuvant therapy for NCCN-defined unresectable pancreatic …
Optimization of dose distributions of target volumes and organs at risk during stereotactic body radiation therapy for pancreatic cancer with dose-limiting auto-shells.
Cao Y, Zhu X, Ju X, Liu Y, Yu C, Sun Y, Dai Z, Guo X, Zhang H. Cao Y, et al. Radiat Oncol. 2018 Jan 22;13(1):11. doi: 10.1186/s13014-018-0956-7. Radiat Oncol. 2018. PMID: 29357875 Free PMC article.
BACKGROUND: To identify optimization of dose distributions of target volumes and decrease of radiation doses to normal tissues during stereotactic body radiation therapy (SBRT) for pancreatic cancer with dose-limiting auto-shells. ...
BACKGROUND: To identify optimization of dose distributions of target volumes and decrease of radiation doses to normal tissues during ste …
Automated inverse optimization facilitates lower doses to normal tissue in pancreatic stereotactic body radiotherapy.
Mihaylov IB, Mellon EA, Yechieli R, Portelance L. Mihaylov IB, et al. PLoS One. 2018 Jan 19;13(1):e0191036. doi: 10.1371/journal.pone.0191036. eCollection 2018. PLoS One. 2018. PMID: 29351303 Free PMC article.
This work introduces a fully automated inverse optimization approach, where the treatment plan is closely tailored to the unique patient anatomy. The auto-optimization is applied to pancreatic stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS: The …
This work introduces a fully automated inverse optimization approach, where the treatment plan is closely tailored to the unique patient ana …
Stereotactic Body Radiation Therapy in the Management of Upper GI Malignancies.
Tchelebi L, Zaorsky N, Mackley H. Tchelebi L, et al. Biomedicines. 2018 Jan 3;6(1):7. doi: 10.3390/biomedicines6010007. Biomedicines. 2018. PMID: 29301352 Free PMC article. Review.
As radiation therapy techniques improve and are able to deliver more ablative doses of radiotherapy while sparing healthy tissue, radiation can be applied to a wider range of clinical scenarios. Stereotactic body radiation therapy (SBRT) allows a high dose of radiat …
As radiation therapy techniques improve and are able to deliver more ablative doses of radiotherapy while sparing healthy tissue, rad …
Efficient Interplay Effect Mitigation for Proton Pencil Beam Scanning by Spot-Adapted Layered Repainting Evenly Spread out Over the Full Breathing Cycle.
Poulsen PR, Eley J, Langner U, Simone CB 2nd, Langen K. Poulsen PR, et al. Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):226-234. doi: 10.1016/j.ijrobp.2017.09.043. Epub 2017 Oct 4. Int J Radiat Oncol Biol Phys. 2018. PMID: 29254775
This strategy could allow for safe and more optimal clinical delivery of thoracic and abdominal proton PBS and better facilitate hypofractionated and stereotactic treatments....
This strategy could allow for safe and more optimal clinical delivery of thoracic and abdominal proton PBS and better facilitate hypofractio …
Locally advanced pancreatic cancer: An emerging entity.
O Kane GM, Knox JJ. O Kane GM, et al. Curr Probl Cancer. 2018 Jan-Feb;42(1):12-25. doi: 10.1016/j.currproblcancer.2017.10.006. Epub 2017 Nov 16. Curr Probl Cancer. 2018. PMID: 29153290 Review.
Pancreatic adenocarcinoma (PDAC) remains a highly fatal disease that is increasing in incidence. ...Local therapies after induction chemotherapy including standard fractionation radiation, stereotactic body radiotherapy (SBRT), and irreversible electroporatio …
Pancreatic adenocarcinoma (PDAC) remains a highly fatal disease that is increasing in incidence. ...Local therapies after induction c …
Stereotactic Body Radiation Therapy for Isolated Local Recurrence After Surgical Resection of Pancreatic Ductal Adenocarcinoma Appears to be Safe and Effective.
Ryan JF, Groot VP, Rosati LM, Hacker-Prietz A, Narang AK, McNutt TR, Jackson JF, Le DT, Jaffee EM, Zheng L, Laheru DA, He J, Pawlik TM, Weiss MJ, Wolfgang CL, Herman JM. Ryan JF, et al. Ann Surg Oncol. 2018 Jan;25(1):280-289. doi: 10.1245/s10434-017-6134-6. Epub 2017 Oct 23. Ann Surg Oncol. 2018. PMID: 29063299
BACKGROUND: A standardized treatment regimen for unresectable isolated local recurrence (ILR) of pancreatic ductal adenocarcinoma has not been established. This study evaluated the outcomes for patients with ILR who underwent stereotactic body radiation therapy (SBR …
BACKGROUND: A standardized treatment regimen for unresectable isolated local recurrence (ILR) of pancreatic ductal adenocarcinoma has …