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Page 1
Showing results for triazin
Your search for triasyn retrieved no results
Synthesis and evaluation of anti-yellow fever virus activity of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones.
Novodvorskyi Y, Lesyk R, Komarov I, Lega D, Zhuravel I, Moskalenko O, Sukhoveev V, Demchenko A. Novodvorskyi Y, et al. Eur J Med Chem. 2023 Feb 15;248:115117. doi: 10.1016/j.ejmech.2023.115117. Epub 2023 Jan 13. Eur J Med Chem. 2023. PMID: 36657300
In this regard, here we describe the synthesis of a series of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones and evaluation of their in vitro inhibitory activity against yellow fever virus. ...
In this regard, here we describe the synthesis of a series of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones and evaluation of their i …
1,3,5-Triazine-azole Hybrids and their Anticancer Activity.
Guo H, Diao QP. Guo H, et al. Curr Top Med Chem. 2020;20(16):1481-1492. doi: 10.2174/1568026620666200310122741. Curr Top Med Chem. 2020. PMID: 32156236 Review.
1,3,5-Triazine and azole can interact with various therapeutic targets, and their derivatives possess promising in vitro and in vivo anticancer activity. ...Substantial efforts have been made to develop azole-containing 1,3,5-triazine hybrids as novel anticancer age …
1,3,5-Triazine and azole can interact with various therapeutic targets, and their derivatives possess promising in vitro and in vivo …
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), design, synthesis and biological evaluation of novel PI3Kalpha selective inhibitors.
Wang Y, Liu Y, Ge T, Tang J, Wang S, Gao Z, Chen J, Xu J, Gong P, Zhao Y, Liu J, Hou Y. Wang Y, et al. Bioorg Chem. 2023 Jan;130:106211. doi: 10.1016/j.bioorg.2022.106211. Epub 2022 Oct 27. Bioorg Chem. 2023. PMID: 36343598
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), three series of novel 1,3,5-triazine or pyrimidine derivatives containing semicarbazones have been designed and synthesized to obtain new potent and selective PI3Kal …
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), three series of novel 1,3,5-t …
(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands.
Kamińska K, Ziemba J, Ner J, Schwed JS, Łażewska D, Więcek M, Karcz T, Olejarz A, Latacz G, Kuder K, Kottke T, Zygmunt M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K. Kamińska K, et al. Eur J Med Chem. 2015 Oct 20;103:238-51. doi: 10.1016/j.ejmech.2015.08.014. Epub 2015 Aug 10. Eur J Med Chem. 2015. PMID: 26360048
A series of novel compounds in the group of 4-methylpiperazine-1,3,5-triazine-2-amines were designed and obtained. Considered structures were modified at the triazine 6-position by introduction of variously substituted arylethenyl moieties. ...Pharmacological studie …
A series of novel compounds in the group of 4-methylpiperazine-1,3,5-triazine-2-amines were designed and obtained. Considered structu …
Functionalized Triazines and Tetrazines: Synthesis and Applications.
Mondal J, Sivaramakrishna A. Mondal J, et al. Top Curr Chem (Cham). 2022 Jun 23;380(5):34. doi: 10.1007/s41061-022-00385-7. Top Curr Chem (Cham). 2022. PMID: 35737142 Review.
The molecules possessing triazine and tetrazine moieties belong to a special class of heterocyclic compounds. ...Synthetic approaches contain linear, angular, and fused triazine and tetrazine heterocycles through a combinatorial method. ...
The molecules possessing triazine and tetrazine moieties belong to a special class of heterocyclic compounds. ...Synthetic approaches …
Synthesis, beta -catenin Translocation Capability and ALP Activation Activity of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives.
Hou S, Xu H, Hu J, Hou J, Wang Y, Jin Z, Wan DCC, Hu C. Hou S, et al. Med Chem. 2018;14(1):67-73. doi: 10.2174/1573406413666171002121443. Med Chem. 2018. PMID: 28969571
The target compounds 3,6-diaryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-ones (3a-3c) were prepared by compound 2 with substituted alkyl chloride by Williamson reaction. As to 6-benzyl-3-aryl-7H-thiazolo[3,2- b]-1,2,4-triazin-7-one derivatives as the target compounds, the …
The target compounds 3,6-diaryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-ones (3a-3c) were prepared by compound 2 with substituted alkyl ch …
Antitumor Activity of s-Triazine Derivatives: A Systematic Review.
Dai Q, Sun Q, Ouyang X, Liu J, Jin L, Liu A, He B, Fan T, Jiang Y. Dai Q, et al. Molecules. 2023 May 23;28(11):4278. doi: 10.3390/molecules28114278. Molecules. 2023. PMID: 37298753 Free PMC article. Review.
1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an important role in anticancer drug design and development. To date, three s-triazine derivatives, including altretamine, gedatolisib, a …
1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an i …
5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists.
Schmitz WD, Brenner AB, Bronson JJ, Ditta JL, Griffin CR, Li YW, Lodge NJ, Molski TF, Olson RE, Zhuo X, Macor JE. Schmitz WD, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3579-83. doi: 10.1016/j.bmcl.2010.04.121. Epub 2010 May 17. Bioorg Med Chem Lett. 2010. PMID: 20483614
A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor receptor. ...
A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor r …
1,3,5-Triazine: A versatile pharmacophore with diverse biological activities.
Singh S, Mandal MK, Masih A, Saha A, Ghosh SK, Bhat HR, Singh UP. Singh S, et al. Arch Pharm (Weinheim). 2021 Jun;354(6):e2000363. doi: 10.1002/ardp.202000363. Epub 2021 Mar 24. Arch Pharm (Weinheim). 2021. PMID: 33760298 Review.
1,3,5-Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer, antiviral, antimicrobial, anti-inflammatory, antiamoebic, and antitubercular …
1,3,5-Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to their effective biological activities …
Pyrazolotriazines: Biological activities, synthetic strategies and recent developments.
Alizadeh SR, Ebrahimzadeh MA. Alizadeh SR, et al. Eur J Med Chem. 2021 Nov 5;223:113537. doi: 10.1016/j.ejmech.2021.113537. Epub 2021 Jun 10. Eur J Med Chem. 2021. PMID: 34147747 Review.
The reactivity of identified compounds was similar to the free azoles and triazines. The pyrazolotriazine scaffold exhibited antiasthma, antiinflammatory, anticancer, antithrombogenic activity and showed activity for major depression and pathological anxiety. ...This paper …
The reactivity of identified compounds was similar to the free azoles and triazines. The pyrazolotriazine scaffold exhibited antiasth …
30,440 results
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