Wexler RR - Search Results

1

Isoxazolines as potent antagonists of the integrin alpha(v)beta(3).

Pitts WJ, Wityak J, Smallheer JM, Tobin AE, Jetter JW, Buynitsky JS, Harlow PP, Solomon KA, Corjay MH, Mousa SA, Wexler RR, Jadhav PK. Pitts WJ, et al. Among authors: wexler rr. J Med Chem. 2000 Jan 13;43(1):27-40. doi: 10.1021/jm9900321. J Med Chem. 2000. PMID: 10633036

2

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.

Carini DJ, Duncia JV, Aldrich PE, Chiu AT, Johnson AL, Pierce ME, Price WA, Santella JB 3rd, Wells GJ, Wexler RR, et al. Carini DJ, et al. Among authors: wexler rr. J Med Chem. 1991 Aug;34(8):2525-47. doi: 10.1021/jm00112a031. J Med Chem. 1991. PMID: 1875348

3

Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.

Quan ML, Chiu AT, Ellis CD, Wong PC, Wexler RR, Timmermans PB. Quan ML, et al. Among authors: wexler rr. J Med Chem. 1995 Jul 21;38(15):2938-45. doi: 10.1021/jm00015a016. J Med Chem. 1995. PMID: 7636854

4

Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles.

Higley CA, Wilde RG, Maduskuie TP, Johnson AL, Pennev P, Billheimer JT, Robinson CS, Gillies PJ, Wexler RR. Higley CA, et al. Among authors: wexler rr. J Med Chem. 1994 Oct 14;37(21):3511-22. doi: 10.1021/jm00047a009. J Med Chem. 1994. PMID: 7932580

5

A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.

VanAtten MK, Ensinger CL, Chiu AT, McCall DE, Nguyen TT, Wexler RR, Timmermans PB. VanAtten MK, et al. Among authors: wexler rr. J Med Chem. 1993 Dec 10;36(25):3985-92. doi: 10.1021/jm00077a001. J Med Chem. 1993. PMID: 8258820

6

Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.

Wexler RR, Greenlee WJ, Irvin JD, Goldberg MR, Prendergast K, Smith RD, Timmermans PB. Wexler RR, et al. J Med Chem. 1996 Feb 2;39(3):625-56. doi: 10.1021/jm9504722. J Med Chem. 1996. PMID: 8576904 Review. No abstract available.

7

ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes.

Wilde RG, Billheimer JT, Germain SJ, Hausner EA, Meunier PC, Munzer DA, Stoltenborg JK, Gillies PJ, Burcham DL, Huang SM, Klaczkiewicz JD, Ko SS, Wexler RR. Wilde RG, et al. Among authors: wexler rr. Bioorg Med Chem. 1996 Sep;4(9):1493-513. doi: 10.1016/0968-0896(96)00143-5. Bioorg Med Chem. 1996. PMID: 8894107

8

Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity.

Mousa SA, Forsythe M, Lorelli W, Bozarth J, Xue CB, Wityak J, Sielecki TM, Olson RE, DeGrado W, Kapil R, Hussain M, Wexler R, Thoolen MJ, Reilly TM. Mousa SA, et al. Coron Artery Dis. 1996 Oct;7(10):767-74. doi: 10.1097/00019501-199610000-00010. Coron Artery Dis. 1996. PMID: 8970768

9

Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists.

Wityak J, Sielecki TM, Pinto DJ, Emmett G, Sze JY, Liu J, Tobin AE, Wang S, Jiang B, Ma P, Mousa SA, Wexler RR, Olson RE. Wityak J, et al. Among authors: wexler rr. J Med Chem. 1997 Jan 3;40(1):50-60. doi: 10.1021/jm960626t. J Med Chem. 1997. PMID: 9016328

10

Oral antiplatelet efficacy and specificity of a novel nonpeptide platelet GPIIb/IIIa receptor antagonist, DMP 802.

Mousa SA, Olson RE, Bozarth JM, Lorelli W, Forsythe MS, Racanelli A, Gibbs S, Schlingman K, Bozarth T, Kapil R, Wityak J, Sielecki TM, Wexler RR, Thoolen MJ, Slee A, Reilly TM, Anderson PS, Friedman PA. Mousa SA, et al. Among authors: wexler rr. J Cardiovasc Pharmacol. 1998 Aug;32(2):169-76. doi: 10.1097/00005344-199808000-00001. J Cardiovasc Pharmacol. 1998. PMID: 9700976

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