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Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.
Gregory MA, Gaisser S, Lill RE, Hong H, Sheridan RM, Wilkinson B, Petkovic H, Weston AJ, Carletti I, Lee HL, Staunton J, Leadlay PF. Gregory MA, et al. Among authors: leadlay pf. Angew Chem Int Ed Engl. 2004 May 3;43(19):2551-3. doi: 10.1002/anie.200453764. Angew Chem Int Ed Engl. 2004. PMID: 15127450 No abstract available.
Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.).
Lowden PA, Wilkinson B, Böhm GA, Handa S, Floss HG, Leadlay PF, Staunton J. Lowden PA, et al. Among authors: leadlay pf. Angew Chem Int Ed Engl. 2001 Feb 16;40(4):777-779. Angew Chem Int Ed Engl. 2001. PMID: 11241621 No abstract available.
Active-site residue, domain and module swaps in modular polyketide synthases.
Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortés J, Rudd BA, Staunton J, Leadlay PF. Del Vecchio F, et al. Among authors: leadlay pf. J Ind Microbiol Biotechnol. 2003 Aug;30(8):489-94. doi: 10.1007/s10295-003-0062-0. Epub 2003 Jun 14. J Ind Microbiol Biotechnol. 2003. PMID: 12811585
Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.
Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall K, McArthur HA, Staunton J, Leadlay PF. Gaisser S, et al. Among authors: leadlay pf. Org Biomol Chem. 2003 Aug 21;1(16):2840-7. doi: 10.1039/b304022d. Org Biomol Chem. 2003. PMID: 12968333
Rapamycin biosynthesis: Elucidation of gene product function.
Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, Wilkinson B, Sheridan RM. Gregory MA, et al. Among authors: leadlay pf. Org Biomol Chem. 2006 Oct 7;4(19):3565-8. doi: 10.1039/b608813a. Epub 2006 Aug 22. Org Biomol Chem. 2006. PMID: 16990929
224 results