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The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase.
Senthong P, Millington CL, Wilkinson OJ, Marriott AS, Watson AJ, Reamtong O, Eyers CE, Williams DM, Margison GP, Povey AC. Senthong P, et al. Among authors: wilkinson oj. Nucleic Acids Res. 2013 Mar 1;41(5):3047-55. doi: 10.1093/nar/gks1476. Epub 2013 Jan 17. Nucleic Acids Res. 2013. PMID: 23335782 Free PMC article.
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations.
Zhang F, Tsunoda M, Suzuki K, Kikuchi Y, Wilkinson O, Millington CL, Margison GP, Williams DM, Czarina Morishita E, Takénaka A. Zhang F, et al. Nucleic Acids Res. 2013 May 1;41(10):5524-32. doi: 10.1093/nar/gkt198. Epub 2013 Apr 10. Nucleic Acids Res. 2013. PMID: 23580550 Free PMC article.
Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O6-methylguanine and their recognition by MGMT and Atl1.
Abdu K, Aiertza MK, Wilkinson OJ, Senthong P, Craggs TD, Povey AC, Margison GP, Williams DM. Abdu K, et al. Among authors: wilkinson oj. Nucleosides Nucleotides Nucleic Acids. 2020;39(8):1108-1121. doi: 10.1080/15257770.2020.1764971. Epub 2020 May 23. Nucleosides Nucleotides Nucleic Acids. 2020. PMID: 32449465 Free article.
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Latypov VF, Tubbs JL, Watson AJ, Marriott AS, McGown G, Thorncroft M, Wilkinson OJ, Senthong P, Butt A, Arvai AS, Millington CL, Povey AC, Williams DM, Santibanez-Koref MF, Tainer JA, Margison GP. Latypov VF, et al. Among authors: wilkinson oj. Mol Cell. 2012 Jul 13;47(1):50-60. doi: 10.1016/j.molcel.2012.04.028. Epub 2012 May 31. Mol Cell. 2012. PMID: 22658721 Free PMC article.
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.
Wilkinson OJ, Latypov V, Tubbs JL, Millington CL, Morita R, Blackburn H, Marriott A, McGown G, Thorncroft M, Watson AJ, Connolly BA, Grasby JA, Masui R, Hunter CA, Tainer JA, Margison GP, Williams DM. Wilkinson OJ, et al. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18755-60. doi: 10.1073/pnas.1209451109. Epub 2012 Oct 29. Proc Natl Acad Sci U S A. 2012. PMID: 23112169 Free PMC article.
19 results