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Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Moye AL, Dost AF, Ietswaart R, Sengupta S, Ya V, Aluya C, Fahey CG, Louie SM, Paschini M, Kim CF. Moye AL, et al. EMBO J. 2024 May 16. doi: 10.1038/s44318-024-00113-5. Online ahead of print. EMBO J. 2024. PMID: 38755258 Free article.
The injury state in AT2(KRAS) cells of patients, mice, and organoids was distinguishable from AT2(WT) states via altered receptor expression, including co-expression of ITGA3 and SRC. ...
The injury state in AT2(KRAS) cells of patients, mice, and organoids was distinguishable from AT2(WT) states via altered receptor exp …
Bone marrow stromal cells induce chromatin remodeling in multiple myeloma cells leading to transcriptional changes.
Binder M, Szalat RE, Talluri S, Fulciniti M, Avet-Loiseau H, Parmigiani G, Samur MK, Munshi NC. Binder M, et al. Nat Commun. 2024 May 16;15(1):4139. doi: 10.1038/s41467-024-47793-5. Nat Commun. 2024. PMID: 38755155 Free PMC article.
Here, we show that the interaction between bone marrow stromal cells and myeloma cells (using human cell lines) induces chromatin remodeling of cis-regulatory elements and is associated with changes in the expression of genes involved in the cell migration and cytokine sig …
Here, we show that the interaction between bone marrow stromal cells and myeloma cells (using human cell lines) induces chromatin rem …
Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling.
Rezvan A, Romain G, Fathi M, Heeke D, Martinez-Paniagua M, An X, Bandey IN, Montalvo MJ, Adolacion JRT, Saeedi A, Sadeghi F, Fousek K, Puebla-Osorio N, Cooper LJN, Bernatchez C, Singh H, Ahmed N, Mattie M, Bot A, Neelapu S, Varadarajan N. Rezvan A, et al. Nat Cancer. 2024 May 15. doi: 10.1038/s43018-024-00768-3. Online ahead of print. Nat Cancer. 2024. PMID: 38750245
Antibodies expand the scope of angiotensin receptor pharmacology.
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC. Skiba MA, et al. Nat Chem Biol. 2024 May 14. doi: 10.1038/s41589-024-01620-6. Online ahead of print. Nat Chem Biol. 2024. PMID: 38744986
G-protein-coupled receptors (GPCRs) are key regulators of human physiology and are the targets of many small-molecule research compounds and therapeutic drugs. ...
G-protein-coupled receptors (GPCRs) are key regulators of human physiology and are the targets of many small-molecule research compou …
GAGE-seq concurrently profiles multiscale 3D genome organization and gene expression in single cells.
Zhou T, Zhang R, Jia D, Doty RT, Munday AD, Gao D, Xin L, Abkowitz JL, Duan Z, Ma J. Zhou T, et al. Nat Genet. 2024 May 14. doi: 10.1038/s41588-024-01745-3. Online ahead of print. Nat Genet. 2024. PMID: 38744973
Here, we introduce genome architecture and gene expression by sequencing (GAGE-seq), a scalable, robust single-cell co-assay measuring 3D genome structure and transcriptome simultaneously within the same cell. Applied to mouse brain cortex and human bone marrow CD34(+) cel …
Here, we introduce genome architecture and gene expression by sequencing (GAGE-seq), a scalable, robust single-cell co-assay measuring 3D ge …
Top-down mass spectrometry of native proteoforms and their complexes: a community study.
Habeck T, Brown KA, Des Soye B, Lantz C, Zhou M, Alam N, Hossain MA, Jung W, Keener JE, Volny M, Wilson JW, Ying Y, Agar JN, Danis PO, Ge Y, Kelleher NL, Li H, Loo JA, Marty MT, Paša-Tolić L, Sandoval W, Lermyte F. Habeck T, et al. Nat Methods. 2024 May 14. doi: 10.1038/s41592-024-02279-6. Online ahead of print. Nat Methods. 2024. PMID: 38744918
ReMIND: The Brain Resection Multimodal Imaging Database.
Juvekar P, Dorent R, Kögl F, Torio E, Barr C, Rigolo L, Galvin C, Jowkar N, Kazi A, Haouchine N, Cheema H, Navab N, Pieper S, Wells WM, Bi WL, Golby A, Frisken S, Kapur T. Juvekar P, et al. Sci Data. 2024 May 14;11(1):494. doi: 10.1038/s41597-024-03295-z. Sci Data. 2024. PMID: 38744868 Free PMC article.
Artificial intelligence in surgery.
Varghese C, Harrison EM, O'Grady G, Topol EJ. Varghese C, et al. Nat Med. 2024 May 13. doi: 10.1038/s41591-024-02970-3. Online ahead of print. Nat Med. 2024. PMID: 38740998 Review.
Reduction of spermine synthase enhances autophagy to suppress Tau accumulation.
Tao X, Liu J, Diaz-Perez Z, Foley JR, Nwafor A, Stewart TM, Casero RA Jr, Zhai RG. Tao X, et al. Cell Death Dis. 2024 May 13;15(5):333. doi: 10.1038/s41419-024-06720-8. Cell Death Dis. 2024. PMID: 38740758 Free PMC article.
Here, we altered SMS expression level to investigate the regulation of autophagy by modulated polyamine metabolism in Tauopathy in Drosophila and human cellular models. Interestingly, while complete loss of Drosophila spermine synthase (dSms) impairs lysosomal function and …
Here, we altered SMS expression level to investigate the regulation of autophagy by modulated polyamine metabolism in Tauopathy in Drosophil …
Adipocyte-Specific Disruption of the BBSome Causes Metabolic and Autonomic Dysfunction.
Zhao Y, Guo DF, Morgan DA, Cho YE, Rahmouni K. Zhao Y, et al. Am J Physiol Regul Integr Comp Physiol. 2024 May 13. doi: 10.1152/ajpregu.00039.2024. Online ahead of print. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 38738295
Obesity is a major public health issue due to its association with type 2 diabetes, hypertension, and other cardiovascular risks. ...
Obesity is a major public health issue due to its association with type 2 diabetes, hypertension, and other cardiovascular risks. ...
Scalable telomere-to-telomere assembly for diploid and polyploid genomes with double graph.
Cheng H, Asri M, Lucas J, Koren S, Li H. Cheng H, et al. Nat Methods. 2024 May 10. doi: 10.1038/s41592-024-02269-8. Online ahead of print. Nat Methods. 2024. PMID: 38730258
Here we present hifiasm (UL), an efficient de novo assembly algorithm combining multiple sequencing technologies to scale up population-wide near telomere-to-telomere assemblies. Applied to 22 human and two plant genomes, our algorithm produces better diploid assemblies at …
Here we present hifiasm (UL), an efficient de novo assembly algorithm combining multiple sequencing technologies to scale up population-wide …
hiPSC-CM Electrophysiology: Impact of Temporal Changes and Study Parameters on Experimental Reproducibility.
Guerrelli D, Pressman J, Salameh S, Posnack NG. Guerrelli D, et al. Am J Physiol Heart Circ Physiol. 2024 May 10. doi: 10.1152/ajpheart.00631.2023. Online ahead of print. Am J Physiol Heart Circ Physiol. 2024. PMID: 38727253
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are frequently used for preclinical cardiotoxicity testing and remain an important tool for confirming model-based predictions of drug effects in accordance with Comprehensive in Vitro Proarrhythmia Ass …
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are frequently used for preclinical cardiotoxicity testing and …
Diffusion-tensor-imaging 1-year-old and 2-year-old infant brain atlases with comprehensive gray and white matter labels.
Song L, Peng Y, Ouyang M, Peng Q, Feng L, Sotardi S, Yu Q, Kang H, Sindabizera KL, Liu S, Huang H. Song L, et al. Hum Brain Mapp. 2024 May;45(7):e26695. doi: 10.1002/hbm.26695. Hum Brain Mapp. 2024. PMID: 38727010 Free PMC article.
Human infancy is marked by fastest postnatal brain structural changes. ...
Human infancy is marked by fastest postnatal brain structural changes. ...
Exercise MR of Skeletal Muscles, the Heart, and the Brain.
Hooijmans MT, Jeneson JAL, Jørstad HT, Bakermans AJ. Hooijmans MT, et al. J Magn Reson Imaging. 2024 May 10. doi: 10.1002/jmri.29445. Online ahead of print. J Magn Reson Imaging. 2024. PMID: 38726984 Review.
Magnetic resonance (MR) imaging (MRI) is routinely used to evaluate organ morphology and pathology in the human body at rest or in combination with pharmacological stress as an exercise surrogate. ...Although not yet integrated in most clinical workflows, and while some ap …
Magnetic resonance (MR) imaging (MRI) is routinely used to evaluate organ morphology and pathology in the human body at rest or in co …
Direct transposition of native DNA for sensitive multimodal single-molecule sequencing.
Nanda AS, Wu K, Irkliyenko I, Woo B, Ostrowski MS, Clugston AS, Sayles LC, Xu L, Satpathy AT, Nguyen HG, Alejandro Sweet-Cordero E, Goodarzi H, Kasinathan S, Ramani V. Nanda AS, et al. Nat Genet. 2024 May 9. doi: 10.1038/s41588-024-01748-0. Online ahead of print. Nat Genet. 2024. PMID: 38724748
We developed two methods that implement tagmentation and use 90-99% less input than current protocols: (1) single-molecule real-time sequencing by tagmentation (SMRT-Tag), which allows detection of genetic variation and CpG methylation; and (2) single-molecule adenine-methylated …
We developed two methods that implement tagmentation and use 90-99% less input than current protocols: (1) single-molecule real-time sequenc …
Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders.
Luo J, Li L, Niu M, Kong D, Jiang Y, Poudel S, Shieh AW, Cheng L, Giase G, Grennan K, White KP, Chen C, Wang SH, Pinto D, Wang Y, Liu C, Peng J, Wang X. Luo J, et al. Mol Psychiatry. 2024 May 9. doi: 10.1038/s41380-024-02576-8. Online ahead of print. Mol Psychiatry. 2024. PMID: 38724566
Genome-wide association studies have identified hundreds of genomic susceptibility loci with susceptibility to psychiatric disorders; however, the contribution of these loci to the underlying psychopathology and etiology remains elusive. Here we generated deep human brain …
Genome-wide association studies have identified hundreds of genomic susceptibility loci with susceptibility to psychiatric disorders; howeve …
Mononuclear phagocyte morphologic response to chemoattractants is dependent on geranylgeranyl pyrophosphate.
Krauklis SA, Hussain J, Murphy KM, Dray EL, Ousley CG, Justyna K, Distefano MD, Steelman AJ, McKim DB. Krauklis SA, et al. Am J Physiol Endocrinol Metab. 2024 May 8. doi: 10.1152/ajpendo.00359.2023. Online ahead of print. Am J Physiol Endocrinol Metab. 2024. PMID: 38717364
Proteomic analysis of C15AlkOPP-prenylated proteins identified several geranylgeranylated proteins involved in chemoattractant responses, including RHOA, RAC1, CDC42, and GNG2. Chemoattractant responses in THP-1 human macrophages were also geranylgeranylation dependent. Th …
Proteomic analysis of C15AlkOPP-prenylated proteins identified several geranylgeranylated proteins involved in chemoattractant responses, in …
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics.
Mongia A, Zohora FT, Burget NG, Zhou Y, Saunders DC, Wang YJ, Brissova M, Powers AC, Kaestner KH, Vahedi G, Naji A, Schwartz GW, Faryabi RB. Mongia A, et al. Nat Commun. 2024 May 3;15(1):3744. doi: 10.1038/s41467-024-47334-0. Nat Commun. 2024. PMID: 38702321 Free PMC article.
However, annotation of cell types and quantification of their relative localization in tissues remain challenging. To address these unmet needs for atlas-scale datasets like Human Pancreas Analysis Program (HPAP), we develop AnnoSpat (Annotator and Spatial Pattern Finder) …
However, annotation of cell types and quantification of their relative localization in tissues remain challenging. To address these unmet ne …
Color morphing surfaces with effective chemical shielding.
Rather AM, Vallabhuneni S, Pyrch AJ, Barrubeeah M, Pillai S, Taassob A, Castellano FN, Kota AK. Rather AM, et al. Nat Commun. 2024 May 3;15(1):3735. doi: 10.1038/s41467-024-48154-y. Nat Commun. 2024. PMID: 38702308 Free PMC article.
A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations.
Saldana-Guerrero IM, Montano-Gutierrez LF, Boswell K, Hafemeister C, Poon E, Shaw LE, Stavish D, Lea RA, Wernig-Zorc S, Bozsaky E, Fetahu IS, Zoescher P, Pötschger U, Bernkopf M, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S, Shoeb MR, Bozatzi P, Rados M, Guarini M, Buri MC, Weninger W, Putz EM, Huang M, Ladenstein R, Andrews PW, Barbaric I, Cresswell GD, Bryant HE, Distel M, Chesler L, Taschner-Mandl S, Farlik M, Tsakiridis A, Halbritter F. Saldana-Guerrero IM, et al. Nat Commun. 2024 May 3;15(1):3745. doi: 10.1038/s41467-024-47945-7. Nat Commun. 2024. PMID: 38702304 Free PMC article.
However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we employ female human embryonic stem cell (hESC) differentiation and single-cell transcriptome and epigenome analysis to assess the effects of chromosome 17q …
However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we employ female human …
Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells.
Yee Mon KJ, Kim S, Dai Z, West JD, Zhu H, Jain R, Grimson A, Rudd BD, Singh A. Yee Mon KJ, et al. Nat Nanotechnol. 2024 Apr 29. doi: 10.1038/s41565-024-01649-7. Online ahead of print. Nat Nanotechnol. 2024. PMID: 38684809
This was done by delivering single or multiple microRNAs to primary naive mouse and human CD8(+) T cells without pre-activation. The use of nanowires further allowed for the delivery of large, whole lentiviral particles with potential for long-term integration. ...
This was done by delivering single or multiple microRNAs to primary naive mouse and human CD8(+) T cells without pre-activation. The …
Respiratory symptoms and outcomes among cigar smokers: findings from the Population Assessment of Tobacco and Health (PATH) study waves 2-5 (2014-2019).
Sharma E, Lauten K, Zebrak KA, Edwards KC, VanEtten S, Benson AF, Delnevo CD, Marshall D, Kimmel HL, Taylor KA, Bansal-Travers M, Hyland A, Cummings KM. Sharma E, et al. Respir Res. 2024 Apr 27;25(1):185. doi: 10.1186/s12931-024-02818-x. Respir Res. 2024. PMID: 38678212 Free PMC article.
METHODS: Data from Waves 2-5 (2014-19) of the Population Assessment of Tobacco and Health (PATH) Study, a nationally representative longitudinal study, were analyzed in two ways. ...CONCLUSIONS: This study provides evidence that cigar smokers or dual smokers of cigars and …
METHODS: Data from Waves 2-5 (2014-19) of the Population Assessment of Tobacco and Health (PATH) Study, a nationally representative l …
Reservoir displacement by an invasive rodent reduces Lassa virus zoonotic spillover risk.
Eskew EA, Bird BH, Ghersi BM, Bangura J, Basinski AJ, Amara E, Bah MA, Kanu MC, Kanu OT, Lavalie EG, Lungay V, Robert W, Vandi MA, Fichet-Calvet E, Nuismer SL. Eskew EA, et al. Nat Commun. 2024 Apr 27;15(1):3589. doi: 10.1038/s41467-024-47991-1. Nat Commun. 2024. PMID: 38678025 Free PMC article.
Here, we use rodent trapping data from Sierra Leone and Guinea to show that R. rattus presence reduces M. natalensis density within the human dwellings where Lassa virus exposure is most likely to occur. ...
Here, we use rodent trapping data from Sierra Leone and Guinea to show that R. rattus presence reduces M. natalensis density within the h …
Perivascular space diffusivity and brain microstructural measures are associated with circadian time and sleep quality.
Brendstrup-Brix K, Ulv Larsen SM, Lee HH, Knudsen GM. Brendstrup-Brix K, et al. J Sleep Res. 2024 Apr 27:e14226. doi: 10.1111/jsr.14226. Online ahead of print. J Sleep Res. 2024. PMID: 38676409
We use diffusion weighted images from 916 young healthy individuals, aged between 22 and 37 years, collected as part of the Human Connectome Project to assess diffusion tensor image analysis along the perivascular space index, white matter fractional anisotropy, intra-neur …
We use diffusion weighted images from 916 young healthy individuals, aged between 22 and 37 years, collected as part of the Human Con …
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
Chen Z, Guo X, Tao R, Huyghe JR, Law PJ, Fernandez-Rozadilla C, Ping J, Jia G, Long J, Li C, Shen Q, Xie Y, Timofeeva MN, Thomas M, Schmit SL, Díez-Obrero V, Devall M, Moratalla-Navarro F, Fernandez-Tajes J, Palles C, Sherwood K, Briggs SEW, Svinti V, Donnelly K, Farrington SM, Blackmur J, Vaughan-Shaw PG, Shu XO, Lu Y, Broderick P, Studd J, Harrison TA, Conti DV, Schumacher FR, Melas M, Rennert G, Obón-Santacana M, Martín-Sánchez V, Oh JH, Kim J, Jee SH, Jung KJ, Kweon SS, Shin MH, Shin A, Ahn YO, Kim DH, Oze I, Wen W, Matsuo K, Matsuda K, Tanikawa C, Ren Z, Gao YT, Jia WH, Hopper JL, Jenkins MA, Win AK, Pai RK, Figueiredo JC, Haile RW, Gallinger S, Woods MO, Newcomb PA, Duggan D, Cheadle JP, Kaplan R, Kerr R, Kerr D, Kirac I, Böhm J, Mecklin JP, Jousilahti P, Knekt P, Aaltonen LA, Rissanen H, Pukkala E, Eriksson JG, Cajuso T, Hänninen U, Kondelin J, Palin K, Tanskanen T, Renkonen-Sinisalo L, Männistö S, Albanes D, Weinstein SJ, Ruiz-Narvaez E, Palmer JR, Buchanan DD, Platz EA, Visvanathan K, Ulrich CM, Siegel E, Brezina S, Gsur A, Campbell PT, Chang-Claude J, Hoffmeister M, Brenner H, Slattery ML, Potter JD, Tsilidis KK, Schulze MB, Gunter MJ, Murphy N, Castells A, Castellví-Bel… See abstract for full author list ➔ Chen Z, et al. Nat Commun. 2024 Apr 26;15(1):3557. doi: 10.1038/s41467-024-47399-x. Nat Commun. 2024. PMID: 38670944 Free PMC article.
Minimizing higher-order aggregation maximizes iron mobilization by small molecules.
Blake AD, Chao J, SantaMaria AM, Ekaputri S, Green KJ, Brown ST, Rakowski CK, Choi EK, Aring L, Chen PJ, Snead NM, Matje DM, Geng T, Octaviani A, Bailey K, Hollenbach SJ, Fan TM, Seo YA, Burke MD. Blake AD, et al. Nat Chem Biol. 2024 Apr 25. doi: 10.1038/s41589-024-01596-3. Online ahead of print. Nat Chem Biol. 2024. PMID: 38664586
Spatial modeling connecting childhood atopic dermatitis prevalence with household exposure to pollutants.
Ratley G, Zeldin J, Sun AA, Yadav M, Chaudhary PP, Myles IA. Ratley G, et al. Commun Med (Lond). 2024 Apr 18;4(1):74. doi: 10.1038/s43856-024-00500-3. Commun Med (Lond). 2024. PMID: 38637696 Free PMC article.
BACKGROUND: Atopic dermatitis (AD) is a chronic, inflammatory disease characterized by dry, pruritic skin. In the U.S., the prevalence of AD has increased over three-fold since the 1970s. ...Meanwhile, synthetic fabric exposure shifts the lipid metabolism of heal …
BACKGROUND: Atopic dermatitis (AD) is a chronic, inflammatory disease characterized by dry, pruritic skin. In the U.S., the pr …
Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption.
Guo Y, Abou Daya F, Le HD, Panda S, Melkani GC. Guo Y, et al. Aging Cell. 2024 Apr 14:e14169. doi: 10.1111/acel.14169. Online ahead of print. Aging Cell. 2024. PMID: 38616316 Free article.
Heart-specific manipulation of Dgat2 modulates cardiac function and lipid droplet accumulation. Strikingly, heart-specific overexpression of human Dgat2 at ZT 0-10 significantly improves cardiac performance in flies exposed to constant light. ...Moreover, our data suggests …
Heart-specific manipulation of Dgat2 modulates cardiac function and lipid droplet accumulation. Strikingly, heart-specific overexpression of …
Differential temporal utility of passively sensed smartphone features for depression and anxiety symptom prediction: a longitudinal cohort study.
Stamatis CA, Meyerhoff J, Meng Y, Lin ZCC, Cho YM, Liu T, Karr CJ, Liu T, Curtis BL, Ungar LH, Mohr DC. Stamatis CA, et al. Npj Ment Health Res. 2024 Jan 4;3(1):1. doi: 10.1038/s44184-023-00041-y. Npj Ment Health Res. 2024. PMID: 38609548 Free PMC article.
We used a shifting window to understand the time scale at which sensed features relate to mental health symptoms, predicting symptoms 2 weeks in the future (distal prediction), 1 week in the future (medial prediction), and 0 weeks in the future (proximal prediction). ...Fi …
We used a shifting window to understand the time scale at which sensed features relate to mental health symptoms, predicting symptoms …
Combined approaches, including long-read sequencing, address the diagnostic challenge of HYDIN in primary ciliary dyskinesia.
Fleming A, Galey M, Briggs L, Edwards M, Hogg C, John S, Wilkinson S, Quinn E, Rai R, Burgoyne T, Rogers A, Patel MP, Griffin P, Muller S, Carr SB, Loebinger MR, Lucas JS, Shah A, Jose R, Mitchison HM, Shoemark A, Miller DE, Morris-Rosendahl DJ. Fleming A, et al. Eur J Hum Genet. 2024 Apr 11. doi: 10.1038/s41431-024-01599-7. Online ahead of print. Eur J Hum Genet. 2024. PMID: 38605126
brainlife.io: a decentralized and open-source cloud platform to support neuroscience research.
Hayashi S, Caron BA, Heinsfeld AS, Vinci-Booher S, McPherson B, Bullock DN, Bertò G, Niso G, Hanekamp S, Levitas D, Ray K, MacKenzie A, Avesani P, Kitchell L, Leong JK, Nascimento-Silva F, Koudoro S, Willis H, Jolly JK, Pisner D, Zuidema TR, Kurzawski JW, Mikellidou K, Bussalb A, Chaumon M, George N, Rorden C, Victory C, Bhatia D, Aydogan DB, Yeh FF, Delogu F, Guaje J, Veraart J, Fischer J, Faskowitz J, Fabrega R, Hunt D, McKee S, Brown ST, Heyman S, Iacovella V, Mejia AF, Marinazzo D, Craddock RC, Olivetti E, Hanson JL, Garyfallidis E, Stanzione D, Carson J, Henschel R, Hancock DY, Stewart CA, Schnyer D, Eke DO, Poldrack RA, Bollmann S, Stewart A, Bridge H, Sani I, Freiwald WA, Puce A, Port NL, Pestilli F. Hayashi S, et al. Nat Methods. 2024 May;21(5):809-813. doi: 10.1038/s41592-024-02237-2. Epub 2024 Apr 11. Nat Methods. 2024. PMID: 38605111 Free PMC article.
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations.
Chandrasekaran SN, Cimini BA, Goodale A, Miller L, Kost-Alimova M, Jamali N, Doench JG, Fritchman B, Skepner A, Melanson M, Kalinin AA, Arevalo J, Haghighi M, Caicedo JC, Kuhn D, Hernandez D, Berstler J, Shafqat-Abbasi H, Root DE, Swalley SE, Garg S, Singh S, Carpenter AE. Chandrasekaran SN, et al. Nat Methods. 2024 Apr 9. doi: 10.1038/s41592-024-02241-6. Online ahead of print. Nat Methods. 2024. PMID: 38594452
Such advancements would accelerate the applications of image-based profiling of cellular states, such as uncovering drug mode of action or probing functional genomics....
Such advancements would accelerate the applications of image-based profiling of cellular states, such as uncovering drug mode of acti …
Dispase/collagenase cocktail allows for coisolation of satellite cells and fibroadipogenic progenitors from human skeletal muscle.
Balayan A, DeBoutray M, Molley TG, Ruoss S, Maceda M, Sevier A, Robertson CM, Ward SR, Engler AJ. Balayan A, et al. Am J Physiol Cell Physiol. 2024 Apr 1;326(4):C1193-C1202. doi: 10.1152/ajpcell.00023.2024. Epub 2024 Mar 4. Am J Physiol Cell Physiol. 2024. PMID: 38581669
Here, we investigated whether a dispase and collagenase type 1 and 2 cocktail could allow dual isolation of SCs and FAPs, enabling significantly increased yield from human skeletal muscle. Postdissociation, we found that single cells could be sorted into CD56 + CD31-CD45- …
Here, we investigated whether a dispase and collagenase type 1 and 2 cocktail could allow dual isolation of SCs and FAPs, enabling significa …
NK Cell-Monocyte Cross-talk Underlies NK Cell Activation in Severe COVID-19.
Lee MJ, de Los Rios Kobara I, Barnard TR, Vales Torres X, Tobin NH, Ferbas KG, Rimoin AW, Yang OO, Aldrovandi GM, Wilk AJ, Fulcher JA, Blish CA. Lee MJ, et al. J Immunol. 2024 Apr 5;212(11):1693-705. doi: 10.4049/jimmunol.2300731. Online ahead of print. J Immunol. 2024. PMID: 38578283 Free PMC article.
To validate these findings, we performed in vitro cocultures in which NK cells from healthy human donors were incubated with monocytes from COVID-19+ or healthy donors. ...
To validate these findings, we performed in vitro cocultures in which NK cells from healthy human donors were incubated with monocyte …
De novo design of pH-responsive self-assembling helical protein filaments.
Shen H, Lynch EM, Akkineni S, Watson JL, Decarreau J, Bethel NP, Benna I, Sheffler W, Farrell D, DiMaio F, Derivery E, De Yoreo JJ, Kollman J, Baker D. Shen H, et al. Nat Nanotechnol. 2024 Apr 3. doi: 10.1038/s41565-024-01641-1. Online ahead of print. Nat Nanotechnol. 2024. PMID: 38570702
Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells.
Moore KM, Pelletier A-N, Lapp S, Metz A, Tharp GK, Lee M, Bhasin SS, Bhasin M, Sékaly R-P, Bosinger SE, Suthar MS. Moore KM, et al. J Virol. 2024 May 14;98(5):e0019424. doi: 10.1128/jvi.00194-24. Epub 2024 Apr 3. J Virol. 2024. PMID: 38567950
Using this assay, we profiled the antiviral landscape in a population of human monocyte-derived dendritic cells infected with ZIKV at the single-cell level. ...In this work, we propose a new paradigm for evaluating the antiviral response to a specific virus, combining an u …
Using this assay, we profiled the antiviral landscape in a population of human monocyte-derived dendritic cells infected with ZIKV at …
Looking backward to plan forward.
Lindsey ML, Kirk JA, LeBlanc AJ, Brunt KR, Carter JR, Hansell Keehan K, Ripplinger CM, Kleinbongard P, Kassiri Z. Lindsey ML, et al. Am J Physiol Heart Circ Physiol. 2024 May 1;326(5):H1155-H1158. doi: 10.1152/ajpheart.00154.2024. Epub 2024 Mar 29. Am J Physiol Heart Circ Physiol. 2024. PMID: 38551484 No abstract available.
Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment.
Maroni G, Krishnan I, Alfieri R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Weetall M, Branstrom A, Braccini G, Cabrera San Millán E, Storti B, Bizzarri R, Kocher O, Daniela Sanchez Bassères DS, Welner RS, Magli MC, Merelli I, Clohessy JG, Ali A, Tenen DG, Levantini E. Maroni G, et al. Cancer Res Commun. 2024 Mar 26;4(3):919-937. doi: 10.1158/2767-9764.CRC-23-0161. Cancer Res Commun. 2024. PMID: 38546390 Free PMC article.
Effects of follicle-stimulating hormone on energy balance and tissue metabolic health after loss of ovarian function.
Libby AE, Solt CM, Jackman MR, Sherk VD, Foright RM, Johnson GC, Nguyen TT, Breit MJ, Hulett N, Rudolph MC, Roberson PA, Wellberg EA, Jambal P, Scalzo RL, Higgins J, Kumar TR, Wierman ME, Pan Z, Shankar K, Klemm DJ, Moreau KL, Kohrt WM, MacLean PS. Libby AE, et al. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E626-E639. doi: 10.1152/ajpendo.00400.2023. Epub 2024 Mar 27. Am J Physiol Endocrinol Metab. 2024. PMID: 38536037
We used an alternate approach to isolate the individual and combined contributions of FSH and E(2) in mediating energy imbalance and changes in tissue-level metabolic health. Female Wistar rats were ovariectomized and given the gonadotropin releasing hormone (GnRH) antagon …
We used an alternate approach to isolate the individual and combined contributions of FSH and E(2) in mediating energy imbalance and changes …
A precision functional atlas of personalized network topography and probabilities.
Hermosillo RJM, Moore LA, Feczko E, Miranda-Domínguez Ó, Pines A, Dworetsky A, Conan G, Mooney MA, Randolph A, Graham A, Adeyemo B, Earl E, Perrone A, Carrasco CM, Uriarte-Lopez J, Snider K, Doyle O, Cordova M, Koirala S, Grimsrud GJ, Byington N, Nelson SM, Gratton C, Petersen S, Feldstein Ewing SW, Nagel BJ, Dosenbach NUF, Satterthwaite TD, Fair DA. Hermosillo RJM, et al. Nat Neurosci. 2024 May;27(5):1000-1013. doi: 10.1038/s41593-024-01596-5. Epub 2024 Mar 26. Nat Neurosci. 2024. PMID: 38532024 Free PMC article.
This atlas is an evolving resource comprising 53,273 individual-specific network maps, from more than 9,900 individuals, across ages and cohorts, including the Adolescent Brain Cognitive Development study, the Developmental Human Connectome Project and others. We also gene …
This atlas is an evolving resource comprising 53,273 individual-specific network maps, from more than 9,900 individuals, across ages and coh …
Downregulation of protein phosphatase 2Aα in asthmatic airway smooth muscle.
Reza MI, Kumar A, Pabelick CM, Britt RD Jr, Prakash YS, Sathish V. Reza MI, et al. Am J Physiol Lung Cell Mol Physiol. 2024 May 1;326(5):L651-L659. doi: 10.1152/ajplung.00050.2024. Epub 2024 Mar 26. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 38529552
We further investigated the functional importance of PP2A by determining its role in bronchoconstriction using mouse bronchus and human ASM cell [Ca(2+)](i) regulation. We found robust expression of PP2A isoforms in human ASM cells with PP2Aalpha being highly expres …
We further investigated the functional importance of PP2A by determining its role in bronchoconstriction using mouse bronchus and human …
High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features.
Sutherland CA, Prigozhin DM, Monroe JG, Krasileva KV. Sutherland CA, et al. EMBO Rep. 2024 May;25(5):2306-2322. doi: 10.1038/s44319-024-00122-9. Epub 2024 Mar 25. EMBO Rep. 2024. PMID: 38528170 Free PMC article.
Our investigation of NLRs in Arabidopsis Col-0 has revealed that hvNLRs show higher expression, less gene body cytosine methylation, and closer proximity to transposable elements than non-hvNLRs. hvNLRs show elevated synonymous and nonsynonymous nucleotide diversity and are in ch …
Our investigation of NLRs in Arabidopsis Col-0 has revealed that hvNLRs show higher expression, less gene body cytosine methylation, and clo …
Multi-omic integration of microbiome data for identifying disease-associated modules.
Muller E, Shiryan I, Borenstein E. Muller E, et al. Nat Commun. 2024 Mar 23;15(1):2621. doi: 10.1038/s41467-024-46888-3. Nat Commun. 2024. PMID: 38521774 Free PMC article.
Multi-omic studies of the human gut microbiome are crucial for understanding its role in disease across multiple functional layers. ...
Multi-omic studies of the human gut microbiome are crucial for understanding its role in disease across multiple functional layers. . …
cGAS meets its demise in the nucleus.
Leonen CJA, Funabiki H. Leonen CJA, et al. Nat Immunol. 2024 Apr;25(4):592-593. doi: 10.1038/s41590-024-01794-0. Nat Immunol. 2024. PMID: 38514888 No abstract available.
The Alzheimer's disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons.
Saha O, Melo de Farias AR, Pelletier A, Siedlecki-Wullich D, Landeira BS, Gadaut J, Carrier A, Vreulx AC, Guyot K, Shen Y, Bonnefond A, Amouyel P, Tcw J, Kilinc D, Queiroz CM, Delahaye F, Lambert JC, Costa MR. Saha O, et al. Mol Psychiatry. 2024 Mar 22. doi: 10.1038/s41380-024-02502-y. Online ahead of print. Mol Psychiatry. 2024. PMID: 38514804
Using single-cell RNA-sequencing on cerebral organoids generated from isogenic BIN1 wild type (WT), heterozygous (HET) and homozygous knockout (KO) human-induced pluripotent stem cells (hiPSCs), we show that BIN1 is mainly expressed by oligodendrocytes and glutamatergic ne …
Using single-cell RNA-sequencing on cerebral organoids generated from isogenic BIN1 wild type (WT), heterozygous (HET) and homozygous knocko …
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.
Liu H, Zakrzewicz D, Nosol K, Irobalieva RN, Mukherjee S, Bang-Sørensen R, Goldmann N, Kunz S, Rossi L, Kossiakoff AA, Urban S, Glebe D, Geyer J, Locher KP. Liu H, et al. Nat Commun. 2024 Mar 20;15(1):2476. doi: 10.1038/s41467-024-46706-w. Nat Commun. 2024. PMID: 38509088 Free PMC article.
Here, to elucidate the basis of this inhibitory function, we determined a cryo-EM structure of BLV-bound human NTCP. BLV forms two domains, a plug lodged in the bile salt transport tunnel of NTCP and a string that covers the receptor's extracellular surface. ...
Here, to elucidate the basis of this inhibitory function, we determined a cryo-EM structure of BLV-bound human NTCP. BLV forms two do …
Human Striatal Association Megaclusters.
Kosakowski HL, Saadon-Grosman N, Du J, Eldaief MC, Buckner RL. Kosakowski HL, et al. J Neurophysiol. 2024 Mar 20. doi: 10.1152/jn.00387.2023. Online ahead of print. J Neurophysiol. 2024. PMID: 38505898 Free article.
Genetics of environmental sensitivity and its association with variations in emotional problems, autistic traits, and wellbeing.
Assary E, Oginni OA, Morneau-Vaillancourt G, Krebs G, Peel AJ, Palaiologou E, Lockhart C, Ronald A, Eley TC. Assary E, et al. Mol Psychiatry. 2024 Mar 18. doi: 10.1038/s41380-024-02508-6. Online ahead of print. Mol Psychiatry. 2024. PMID: 38499655
Greater environmental sensitivity has been associated with increased risk of mental health problems, especially in response to stressors, and lower levels of subjective wellbeing. ...
Greater environmental sensitivity has been associated with increased risk of mental health problems, especially in response to stress …
Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination.
Zeng YC, Young OJ, Wintersinger CM, Anastassacos FM, MacDonald JI, Isinelli G, Dellacherie MO, Sobral M, Bai H, Graveline AR, Vernet A, Sanchez M, Mulligan K, Choi Y, Ferrante TC, Keskin DB, Fell GG, Neuberg D, Wu CJ, Mooney DJ, Kwon IC, Ryu JH, Shih WM. Zeng YC, et al. Nat Nanotechnol. 2024 Mar 15. doi: 10.1038/s41565-024-01615-3. Online ahead of print. Nat Nanotechnol. 2024. PMID: 38491184
Developing an individualized treatment rule for Veterans with major depressive disorder using electronic health records.
Zainal NH, Bossarte RM, Gildea SM, Hwang I, Kennedy CJ, Liu H, Luedtke A, Marx BP, Petukhova MV, Post EP, Ross EL, Sampson NA, Sverdrup E, Turner B, Wager S, Kessler RC. Zainal NH, et al. Mol Psychiatry. 2024 Mar 14. doi: 10.1038/s41380-024-02500-0. Online ahead of print. Mol Psychiatry. 2024. PMID: 38486050
The current report presents a proof-of-concept study using electronic health records (EHR) of n = 43,470 outpatients beginning MDD treatment in Veterans Health Administration Primary Care Mental Health Integration (PC-MHI) clinics, which offer access not only …
The current report presents a proof-of-concept study using electronic health records (EHR) of n = 43,470 outpatients beginning MDD tr …
Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results.
Bagley SJ, Logun M, Fraietta JA, Wang X, Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins R, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz R, Jadlowsky JK, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen F, Sun Y, Gladney W, Barrett D, Nasrallah MP, Hwang WT, Ming GL, Song H, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke DM. Bagley SJ, et al. Nat Med. 2024 Mar 13. doi: 10.1038/s41591-024-02893-z. Online ahead of print. Nat Med. 2024. PMID: 38480922
In exploratory endpoint analyses, substantial CAR T cell abundance and cytokine release in the cerebrospinal fluid were detected in all six patients. Taken together, these first-in-human data demonstrate the preliminary safety and bioactivity of CART-EGFR-IL13Ralpha2 cells …
In exploratory endpoint analyses, substantial CAR T cell abundance and cytokine release in the cerebrospinal fluid were detected in all six …
Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways.
Wang Y, Li S, Hu M, Yang Y, McCabe E, Zhang L, Withrow AM, Ting JP, Liu R. Wang Y, et al. Nat Nanotechnol. 2024 Mar 13. doi: 10.1038/s41565-024-01624-2. Online ahead of print. Nat Nanotechnol. 2024. PMID: 38480836
Here we report a universal STING mimic (uniSTING) based on a polymeric architecture. UniSTING activates STING signalling in a range of mouse and human cell types, independent of endogenous STING expression, and selectively stimulates tumour control IRF3/IFN-I pathways, but …
Here we report a universal STING mimic (uniSTING) based on a polymeric architecture. UniSTING activates STING signalling in a range of mouse …
The antiemetic actions of GIP receptor agonism.
Borner T, De Jonghe BC, Hayes MR. Borner T, et al. Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E528-E536. doi: 10.1152/ajpendo.00330.2023. Epub 2024 Mar 13. Am J Physiol Endocrinol Metab. 2024. PMID: 38477667 Review.
Effectiveness of lapatinib for enhancing 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy in human cancer cell lines with varied ABCG2 activities.
Howley R, Olsen J, Chen B. Howley R, et al. Photochem Photobiol. 2024 Mar 13. doi: 10.1111/php.13936. Online ahead of print. Photochem Photobiol. 2024. PMID: 38477138
ABCG2 activities and protein levels were determined in a panel of human cancer cell lines. Effects of lapatinib and Ko143 on enhancing ALA-PpIX fluorescence and PDT were evaluated and correlated with tumor cell ABCG2 activities. ...
ABCG2 activities and protein levels were determined in a panel of human cancer cell lines. Effects of lapatinib and Ko143 on enhancin …
The direction of theta and alpha travelling waves modulates human memory processing.
Mohan UR, Zhang H, Ermentrout B, Jacobs J. Mohan UR, et al. Nat Hum Behav. 2024 Mar 8. doi: 10.1038/s41562-024-01838-3. Online ahead of print. Nat Hum Behav. 2024. PMID: 38459263
Although travelling waves are present across the brain in various species, their potential functional relevance has remained unknown. Here, using rare direct human brain recordings, we demonstrate a distinct functional role for travelling waves of theta- and alpha-band (2- …
Although travelling waves are present across the brain in various species, their potential functional relevance has remained unknown. Here, …
α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor.
Suominen A, Saldo Rubio G, Ruohonen S, Szabó Z, Pohjolainen L, Ghimire B, Ruohonen ST, Saukkonen K, Ijas J, Skarp S, Kaikkonen L, Cai M, Wardlaw SL, Ruskoaho H, Talman V, Savontaus E, Kerkelä R, Rinne P. Suominen A, et al. EMBO Rep. 2024 Apr;25(4):1987-2014. doi: 10.1038/s44319-024-00109-6. Epub 2024 Mar 7. EMBO Rep. 2024. PMID: 38454158 Free PMC article.
Lipid droplets and cellular lipid flux.
Mathiowetz AJ, Olzmann JA. Mathiowetz AJ, et al. Nat Cell Biol. 2024 Mar;26(3):331-345. doi: 10.1038/s41556-024-01364-4. Epub 2024 Mar 7. Nat Cell Biol. 2024. PMID: 38454048 Review.
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation.
Zhang R, Fang J, Xie X, Carrico C, Meyer JG, Wei L, Bons J, Rose J, Riley R, Kwok R, Ashok Kumaar PV, Zhang Y, He W, Nishida Y, Liu X, Locasale JW, Schilling B, Verdin E. Zhang R, et al. Nat Metab. 2024 Mar;6(3):550-566. doi: 10.1038/s42255-024-01005-y. Epub 2024 Mar 6. Nat Metab. 2024. PMID: 38448615
N-glycosylation of the SARS-CoV-2 spike protein at Asn331 and Asn343 is involved in spike-ACE2 binding, virus entry, and regulation of IL-6.
Das T, Luo S, Tang H, Fang J, Mao Y, Yen HH, Dash S, Shajahan A, Pepi L, Huang S, Jones VS, Xie S, Huang GF, Lu J, Anderson B, Zhang B, Azadi P, Huang RP. Das T, et al. Microbiol Immunol. 2024 May;68(5):165-178. doi: 10.1111/1348-0421.13121. Epub 2024 Mar 6. Microbiol Immunol. 2024. PMID: 38444370
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing global public health crisis. The causative agent, the SARS-CoV-2 virus, enters host cells via molecular interactions between the viral spike protein and the host cell ACE2 surface protein. ...
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing global public health crisis. The causative agent, the SARS-CoV-2 virus …
Hepatic LGR4 aggravates cholestasis-induced liver injury in mice.
Gao Y, Zhai W, Sun L, Du X, Wang X, Mulholland MW, Yin Y, Zhang W. Gao Y, et al. Am J Physiol Gastrointest Liver Physiol. 2024 Apr 1;326(4):G460-G472. doi: 10.1152/ajpgi.00127.2023. Epub 2024 Mar 5. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 38440827
The Irreversible FGFR Inhibitor KIN-3248 Overcomes FGFR2 Kinase Domain Mutations.
Balasooriya ER, Wu Q, Ellis H, Zhen Y, Norden BL, Corcoran RB, Mohan A, Martin E, Franovic A, Tyhonas J, Lardy M, Grandinetti KB, Pelham R, Soroceanu L, Silveira VS, Bardeesy N. Balasooriya ER, et al. Clin Cancer Res. 2024 May 15;30(10):2181-2192. doi: 10.1158/1078-0432.CCR-23-3588. Clin Cancer Res. 2024. PMID: 38437671
Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1.
Bonner X, Sondgeroth A, McCue A, Nicely N, Tripathy A, Spielvogel E, Moeser M, Ke R, Leiderman K, Joseph SB, Swanstrom R. Bonner X, et al. mBio. 2024 Apr 10;15(4):e0032124. doi: 10.1128/mbio.00321-24. Epub 2024 Mar 1. mBio. 2024. PMID: 38426750 Free article.
Human immunodeficiency virus type 1 typically requires a high density of CD4 for efficient entry as a mechanism to target CD4+ T cells (T-tropic), with CCR5 being used most often as the coreceptor. ...Collectively, these studies reveal differences in the stoichiometry of i …
Human immunodeficiency virus type 1 typically requires a high density of CD4 for efficient entry as a mechanism to target CD4+ T cell …
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.
Aracena KA, Lin YL, Luo K, Pacis A, Gona S, Mu Z, Yotova V, Sindeaux R, Pramatarova A, Simon MM, Chen X, Groza C, Lougheed D, Gregoire R, Brownlee D, Boye C, Pique-Regi R, Li Y, He X, Bujold D, Pastinen T, Bourque G, Barreiro LB. Aracena KA, et al. Nat Genet. 2024 Mar;56(3):408-419. doi: 10.1038/s41588-024-01668-z. Epub 2024 Feb 29. Nat Genet. 2024. PMID: 38424460
A guideline on the molecular ecosystem regulating ferroptosis.
Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. Dai E, et al. Nat Cell Biol. 2024 Feb 29. doi: 10.1038/s41556-024-01360-8. Online ahead of print. Nat Cell Biol. 2024. PMID: 38424270 Review.
Current progress towards prevention of Nipah and Hendra disease in humans: A scoping review of vaccine and monoclonal antibody candidates being evaluated in clinical trials.
Rodrigue V, Gravagna K, Yao J, Nafade V, Basta NE. Rodrigue V, et al. Trop Med Int Health. 2024 May;29(5):354-364. doi: 10.1111/tmi.13979. Epub 2024 Feb 28. Trop Med Int Health. 2024. PMID: 38415314 Review.
OBJECTIVES: Nipah and Hendra are deadly zoonotic diseases with pandemic potential. To date, no human vaccine or monoclonal antibody (mAb) has been licensed to prevent disease caused by these pathogens. ...RESULTS: Three vaccine candidates (Hendra Virus Soluble Glycoprotein …
OBJECTIVES: Nipah and Hendra are deadly zoonotic diseases with pandemic potential. To date, no human vaccine or monoclonal antibody ( …
HIV-1 RNA genome packaging: it's G-rated.
Duchon A, Hu W-S. Duchon A, et al. mBio. 2024 Apr 10;15(4):e0086123. doi: 10.1128/mbio.00861-23. Epub 2024 Feb 27. mBio. 2024. PMID: 38411060 Free PMC article. Review.
A member of the Retroviridae, human immunodeficiency virus type 1 (HIV-1), uses the RNA genome packaged into nascent virions to transfer genetic information to its progeny. ...
A member of the Retroviridae, human immunodeficiency virus type 1 (HIV-1), uses the RNA genome packaged into nascent virions to trans …
Multi-scale V-net architecture with deep feature CRF layers for brain extraction.
Park JS, Fadnavis S, Garyfallidis E. Park JS, et al. Commun Med (Lond). 2024 Feb 23;4(1):29. doi: 10.1038/s43856-024-00452-8. Commun Med (Lond). 2024. PMID: 38396078 Free PMC article.
However, the complex structure of the interfaces between the brain, meninges and human skull have not allowed a highly robust solution to emerge. ...
However, the complex structure of the interfaces between the brain, meninges and human skull have not allowed a highly robust solutio …
rMATS-turbo: an efficient and flexible computational tool for alternative splicing analysis of large-scale RNA-seq data.
Wang Y, Xie Z, Kutschera E, Adams JI, Kadash-Edmondson KE, Xing Y. Wang Y, et al. Nat Protoc. 2024 Apr;19(4):1083-1104. doi: 10.1038/s41596-023-00944-2. Epub 2024 Feb 23. Nat Protoc. 2024. PMID: 38396040 Review.
Regulated alternative splicing plays a role in many biological processes, and dysregulated alternative splicing is a feature of many human diseases. Short-read RNA sequencing (RNA-seq) is now the standard approach for transcriptome-wide analysis of alternative splicing. .. …
Regulated alternative splicing plays a role in many biological processes, and dysregulated alternative splicing is a feature of many huma …
Relationship between serum β-hydroxybutyrate and hepatic fatty acid oxidation in individuals with obesity and NAFLD.
Moore MP, Shryack G, Alessi I, Wieschhaus N, Meers GM, Johnson SA, Wheeler AA, Ibdah JA, Parks EJ, Rector RS. Moore MP, et al. Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E493-E502. doi: 10.1152/ajpendo.00336.2023. Epub 2024 Feb 21. Am J Physiol Endocrinol Metab. 2024. PMID: 38381399
Our findings support the utility of serum beta-HB to serve as a marker of liver injury and hepatic FAO in the context of NAFLD.NEW & NOTEWORTHY Serum beta-hydroxybutyrate (beta-HB) is frequently utilized as a surrogate marker for hepatic fatty acid oxidation; however, few stu …
Our findings support the utility of serum beta-HB to serve as a marker of liver injury and hepatic FAO in the context of NAFLD.NEW & NOT …
Generation of complex bone marrow organoids from human induced pluripotent stem cells.
Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C. Frenz-Wiessner S, et al. Nat Methods. 2024 May;21(5):868-881. doi: 10.1038/s41592-024-02172-2. Epub 2024 Feb 19. Nat Methods. 2024. PMID: 38374263 Free PMC article.
The human bone marrow (BM) niche sustains hematopoiesis throughout life. ...We show that the BMOs could enable the modeling of hematopoietic developmental aspects and inborn errors of hematopoiesis, as shown for human VPS45 deficiency. Thus, iPSC-derived BMOs serve …
The human bone marrow (BM) niche sustains hematopoiesis throughout life. ...We show that the BMOs could enable the modeling of hemato …
Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions.
Gherman S, Markowitz N, Tostaeva G, Espinal E, Mehta AD, O'Connell RG, Kelly SP, Bickel S. Gherman S, et al. Nat Hum Behav. 2024 Apr;8(4):758-770. doi: 10.1038/s41562-024-01824-9. Epub 2024 Feb 16. Nat Hum Behav. 2024. PMID: 38366105
Our findings offer a new view on the brain networks governing human decision-making....
Our findings offer a new view on the brain networks governing human decision-making....
Dietary macronutrient composition impacts gene regulation in adipose tissue.
Farris KM, Senior AM, Sobreira DR, Mitchell RM, Weber ZT, Ingerslev LR, Barrès R, Simpson SJ, Crean AJ, Nobrega MA. Farris KM, et al. Commun Biol. 2024 Feb 16;7(1):194. doi: 10.1038/s42003-024-05876-5. Commun Biol. 2024. PMID: 38365885 Free PMC article.
Diet is a key lifestyle component that influences metabolic health through several factors, including total energy intake and macronutrient composition. ...
Diet is a key lifestyle component that influences metabolic health through several factors, including total energy intake and macronu …
Annotating microbial functions with ProkFunFind.
Dufault-Thompson K, Jiang X. Dufault-Thompson K, et al. mSystems. 2024 Mar 19;9(3):e0003624. doi: 10.1128/msystems.00036-24. Epub 2024 Feb 16. mSystems. 2024. PMID: 38364094 Free PMC article.
Machine learning for functional protein design.
Notin P, Rollins N, Gal Y, Sander C, Marks D. Notin P, et al. Nat Biotechnol. 2024 Feb;42(2):216-228. doi: 10.1038/s41587-024-02127-0. Epub 2024 Feb 15. Nat Biotechnol. 2024. PMID: 38361074 Review.
Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.
Sakai T, Choo YY, Mitsuhashi S, Ikebe R, Jeffers A, Idell S, Tucker TA, Ikebe M. Sakai T, et al. Am J Physiol Lung Cell Mol Physiol. 2024 Apr 1;326(4):L419-L430. doi: 10.1152/ajplung.00271.2023. Epub 2024 Feb 13. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 38349126
Here, we studied the mechanism that regulates FN1 expression in myofibroblasts derived from human pleural mesothelial cells (HPMCs). We found that myocardin (Myocd), a transcriptional coactivator of serum response factor (SRF) and a master regulator of smooth muscle and ca …
Here, we studied the mechanism that regulates FN1 expression in myofibroblasts derived from human pleural mesothelial cells (HPMCs). …
Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope.
Wu J, Chen Y, Veeraraghavan A, Seidemann E, Robinson JT. Wu J, et al. Nat Commun. 2024 Feb 10;15(1):1271. doi: 10.1038/s41467-024-45417-6. Nat Commun. 2024. PMID: 38341403 Free PMC article.
Unfortunately, existing systems for imaging calcium dynamics over large areas in non-human primates (NHPs) are table-top devices that require restraint of the animal's head. Here, we demonstrate an imaging device capable of imaging mesoscale calcium activity in a head-unre …
Unfortunately, existing systems for imaging calcium dynamics over large areas in non-human primates (NHPs) are table-top devices that …
How Does Anticipated HIV Stigma Affect Medication Adherence? A Longitudinal Path Analysis Model.
Yuan GF, Qiao S, Li X, Shen Z, Zhou Y. Yuan GF, et al. AIDS Behav. 2024 May;28(5):1684-1693. doi: 10.1007/s10461-024-04293-3. Epub 2024 Feb 10. AIDS Behav. 2024. PMID: 38340222
Such an understanding has important implications for the development of tailored interventions and public health strategies aimed at improving medication adherence among PLWH in the context of HIV-related stigma....
Such an understanding has important implications for the development of tailored interventions and public health strategies aimed at …
Exploring the Longitudinal Influence of Perceived Social Support, HIV Stigma, and Future Orientation on Depressive Symptoms Among People Living with HIV in China.
Yuan GF, Zhang R, Qiao S, Li X, Shen Z, Zhou Y. Yuan GF, et al. AIDS Behav. 2024 May;28(5):1662-1672. doi: 10.1007/s10461-024-04292-4. Epub 2024 Feb 8. AIDS Behav. 2024. PMID: 38329557
Prior studies demonstrated that perceived social support is negatively associated with behavioral and mental health problems among people living with HIV (PLWH). ...Results indicated that perceived social support at baseline was negatively related to depressi …
Prior studies demonstrated that perceived social support is negatively associated with behavioral and mental health problems a …
Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures.
Podvin S, Jones J, Kang A, Goodman R, Reed P, Lietz CB, Then J, Lee KC, Eyler LT, Jeste DV, Gage FH, Hook V. Podvin S, et al. Mol Psychiatry. 2024 Feb 2. doi: 10.1038/s41380-024-02422-x. Online ahead of print. Mol Psychiatry. 2024. PMID: 38302561
To gain an understanding of human SZ, induced neurons (iNs) were derived from SZ patients and healthy control subjects to investigate peptide neurotransmitters, known as neuropeptides, which represent the major class of transmitters. ...These findings suggest that iNs deri …
To gain an understanding of human SZ, induced neurons (iNs) were derived from SZ patients and healthy control subjects to investigate …
Rethinking force steadiness: a new perspective.
Yacoubi B, Christou EA. Yacoubi B, et al. J Appl Physiol (1985). 2024 May 1;136(5):1260-1262. doi: 10.1152/japplphysiol.00860.2023. Epub 2024 Feb 1. J Appl Physiol (1985). 2024. PMID: 38299220 No abstract available.
"Pscore": A Novel Percentile-Based Metric to Accurately Assess Individual Deviations in Non-Gaussian Distributions of Quantitative MRI Metrics.
Hafiz R, Irfanoglu MO, Nayak A, Pierpaoli C. Hafiz R, et al. J Magn Reson Imaging. 2024 Jan 30. doi: 10.1002/jmri.29248. Online ahead of print. J Magn Reson Imaging. 2024. PMID: 38291798
POPULATION: Nine hundred and sixty-one healthy young adults (age: 22-35 years, females: 53%) from the Human Connectome Project. FIELD STRENGTH/SEQUENCE: 3-T, spin-echo diffusion echo-planar imaging, T1-weighted: MPRAGE. ...
POPULATION: Nine hundred and sixty-one healthy young adults (age: 22-35 years, females: 53%) from the Human Connectome Project. FIELD …
Production and use of antigen tetramers to study antigen-specific B cells.
Phelps A, Pazos-Castro D, Urselli F, Grydziuszko E, Mann-Delany O, Fang A, Walker TD, Guruge RT, Tome-Amat J, Diaz-Perales A, Waserman S, Boonyaratanakornkit J, Jordana M, Taylor JJ, Koenig JFE. Phelps A, et al. Nat Protoc. 2024 Mar;19(3):727-751. doi: 10.1038/s41596-023-00930-8. Epub 2024 Jan 19. Nat Protoc. 2024. PMID: 38243093 Review.
Sex-specific differences in systemic immune responses in MIS-C children.
Rajamanickam A, Kumar NP, Venkataraman A, Varadarjan P, Selladurai E, Sankaralingam T, Thiruvengadam K, Selvam R, Thimmaiah A, Natarajan S, Ramaswamy G, Putlibai S, Sadasivam K, Sundaram B, Hissar S, Ranganathan UD, Babu S. Rajamanickam A, et al. Sci Rep. 2024 Jan 19;14(1):1720. doi: 10.1038/s41598-024-52116-1. Sci Rep. 2024. PMID: 38243064 Free PMC article.
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