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Human cytomegalovirus in breast milk is associated with milk composition and the infant gut microbiome and growth.
Johnson KE, Hernandez-Alvarado N, Blackstad M, Heisel T, Allert M, Fields DA, Isganaitis E, Jacobs KM, Knights D, Lock EF, Rudolph MC, Gale CA, Schleiss MR, Albert FW, Demerath EW, Blekhman R. Johnson KE, et al. Nat Commun. 2024 Jul 23;15(1):6216. doi: 10.1038/s41467-024-50282-4. Nat Commun. 2024. PMID: 39043677 Free PMC article.
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that is often transmitted to the neonate via breast milk. Postnatal CMV transmission can have negative health consequences for preterm and immunocompromised infants, but any effects on healthy term infant
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that is often transmitted to the neonate via breast milk. Postnatal CMV
Reprogramming human B cells with custom heavy-chain antibodies.
Rogers GL, Huang C, Mathur A, Huang X, Chen HY, Stanten K, Morales H, Chang CH, Kezirian EJ, Cannon PM. Rogers GL, et al. Nat Biomed Eng. 2024 Jul 22. doi: 10.1038/s41551-024-01240-4. Online ahead of print. Nat Biomed Eng. 2024. PMID: 39039240
Using the envelope protein (Env) from the human immunodeficiency virus as a model antigen, we show that B cells edited to express heavy-chain antibodies to Env support the regulated expression of B cell receptors and antibodies through alternative splicing and that the cel …
Using the envelope protein (Env) from the human immunodeficiency virus as a model antigen, we show that B cells edited to express hea …
Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses.
Johnson BS, Farkas D, El-Mergawy R, Adair JA, Elhance A, Eltobgy M, Coan FM, Chafin L, Joseph JA, Cornwell A, Johns FJ, Rosas L, Rojas M, Farkas L, Bednash JS, Londino JD, Ray P, Ray A, Kagan V, Lee JS, Chen BB, Mallampalli RK. Johnson BS, et al. Nat Commun. 2024 Jul 22;15(1):6172. doi: 10.1038/s41467-024-50031-7. Nat Commun. 2024. PMID: 39039092 Free PMC article.
Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task.
Savage HS, Mulders PCR, van Eijndhoven PFP, van Oort J, Tendolkar I, Vrijsen JN, Beckmann CF, Marquand AF. Savage HS, et al. Commun Biol. 2024 Jul 20;7(1):888. doi: 10.1038/s42003-024-06573-z. Commun Biol. 2024. PMID: 39033247 Free article.
We apply this model to a heterogenous patient cohort, to map individual differences between patients with one or more mental health diagnoses relative to the reference cohort and determine multivariate associations with transdiagnostic symptom domains. ...
We apply this model to a heterogenous patient cohort, to map individual differences between patients with one or more mental health d …
Advances in induced pluripotent stem cell-derived cardiac myocytes: technological breakthroughs, key discoveries and new applications.
Clancy CE, Santana LF. Clancy CE, et al. J Physiol. 2024 Jul 20. doi: 10.1113/JP282562. Online ahead of print. J Physiol. 2024. PMID: 39032073
Here, we delve into these advancements and their future promise, focusing on the efficiency of reprogramming techniques, the fidelity of differentiation into the cardiac lineage, the functional characterization of the resulting cardiac myocytes, and the many applications of in si …
Here, we delve into these advancements and their future promise, focusing on the efficiency of reprogramming techniques, the fidelity of dif …
Large language models outperform mental and medical health care professionals in identifying obsessive-compulsive disorder.
Kim J, Leonte KG, Chen ML, Torous JB, Linos E, Pinto A, Rodriguez CI. Kim J, et al. NPJ Digit Med. 2024 Jul 19;7(1):193. doi: 10.1038/s41746-024-01181-x. NPJ Digit Med. 2024. PMID: 39030292 Free article.
We assessed the diagnostic accuracy of LLMs in OCD using vignettes and found that LLMs outperformed medical and mental health professionals. This highlights the potential benefit of LLMs in assisting in the timely and accurate diagnosis of OCD, which usually entails a long …
We assessed the diagnostic accuracy of LLMs in OCD using vignettes and found that LLMs outperformed medical and mental health profess …
The effects of in utero exposure to delta-9-tetrahydrocannabinol (THC) on cardiac extracellular matrix expression and vascular transcriptome in rhesus macaques.
Le H, Shorey-Kendrick LE, Hinds MT, McCarty OJT, Lo JO, Anderson DEJ. Le H, et al. Am J Physiol Heart Circ Physiol. 2024 Jul 19. doi: 10.1152/ajpheart.00181.2024. Online ahead of print. Am J Physiol Heart Circ Physiol. 2024. PMID: 39028280
Delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis, remains a schedule I substance, thus safety data regarding the effects on the cardiovascular and prenatal health are limited. Importantly, there is evidence showing prenatal cannabis exposure can n …
Delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis, remains a schedule I substance, thus safety data regarding the e …
Pre-diagnosis tea and coffee consumption and survival after a diagnosis of ovarian cancer: results from the Ovarian Cancer Association Consortium.
Nagle CM, Ibiebele TI, Bandera EV, Cramer D, Doherty JA, Giles GG, Goodman MT, Hanley GE, Harris HR, Jensen A, Kjaer SK, Lee AW, Milne RL, Qin B, Richardson J, Sasamoto N, Sieh W, Terry KL, Titus L, Trabert B, Wentzensen N, Wu AH, Berchuck A, Pike M, Pearce CL, Webb PM. Nagle CM, et al. Br J Cancer. 2024 Jul 18. doi: 10.1038/s41416-024-02792-7. Online ahead of print. Br J Cancer. 2024. PMID: 39026080
Chromatin conformation and histone modification profiling across human kidney anatomic regions.
Li H, Li D, Humphreys BD. Li H, et al. Sci Data. 2024 Jul 18;11(1):797. doi: 10.1038/s41597-024-03648-8. Sci Data. 2024. PMID: 39025878 Free PMC article.
The three major anatomic regions of the human kidney include the cortex, medulla and papilla, with different functions and vulnerabilities to kidney diseases. ...All raw and processed data files are publicly available, allowing researchers to survey the epigenetic landscap …
The three major anatomic regions of the human kidney include the cortex, medulla and papilla, with different functions and vulnerabil …
Increased hepatic putrescine levels as a new potential factor related to the progression of metabolic dysfunction-associated steatotic liver disease.
Núñez-Sánchez MÁ, Martínez-Sánchez MA, Sierra-Cruz M, Lambertos A, Rico-Chazarra S, Oliva-Bolarín A, Balaguer-Román A, Yuste JE, Martínez CM, Mika A, Frutos MD, Llamoza-Torres CJ, Córdoba-Chacón J, Ramos-Molina B. Núñez-Sánchez MÁ, et al. J Pathol. 2024 Jul 18. doi: 10.1002/path.6330. Online ahead of print. J Pathol. 2024. PMID: 39022853
Despite the relatively high incidence of MASH in the population and its potential detrimental effects on human health, this liver disease is still not fully understood from a pathophysiological perspective. ...Furthermore, we found that the levels of putrescine were …
Despite the relatively high incidence of MASH in the population and its potential detrimental effects on human health, this li …
Role of WAVE3 as an of actin binding protein in the pathology of triple negative breast cancer.
Master K, El Khalki L, Bayachou M, Sossey-Alaoui K. Master K, et al. Cytoskeleton (Hoboken). 2024 Jul 18. doi: 10.1002/cm.21898. Online ahead of print. Cytoskeleton (Hoboken). 2024. PMID: 39021344 Review.
Breast cancer, a prevalent global health concern, has sparked extensive research efforts, particularly focusing on triple negative breast cancer (TNBC), a subtype lacking estrogen receptor (ER), progesterone receptor, and epidermal growth factor receptor. ...
Breast cancer, a prevalent global health concern, has sparked extensive research efforts, particularly focusing on triple negative br …
Cytoplasmic stirring by active carpets.
Chakrabarti B, Rachh M, Shvartsman SY, Shelley MJ. Chakrabarti B, et al. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2405114121. doi: 10.1073/pnas.2405114121. Epub 2024 Jul 16. Proc Natl Acad Sci U S A. 2024. PMID: 39012825
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells.
Thakore PI, Schnell A, Huang L, Zhao M, Hou Y, Christian E, Zaghouani S, Wang C, Singh V, Singaraju A, Krishnan RK, Kozoriz D, Ma S, Sankar V, Notarbartolo S, Buenrostro JD, Sallusto F, Patsopoulos NA, Rozenblatt-Rosen O, Kuchroo VK, Regev A. Thakore PI, et al. Nat Immunol. 2024 Jul 15. doi: 10.1038/s41590-024-01901-1. Online ahead of print. Nat Immunol. 2024. PMID: 39009838
We validate that BACH2 promotes immunomodulatory npT(H)17 programs and restrains proinflammatory T(H)1-like programs in T(H)17 cells in vitro and in vivo. Furthermore, human genetics implicate BACH2 in multiple sclerosis. Overall, our work identifies regulators of T(H)17 h …
We validate that BACH2 promotes immunomodulatory npT(H)17 programs and restrains proinflammatory T(H)1-like programs in T(H)17 cells in vitr …
Beta activity in human anterior cingulate cortex mediates reward biases.
Xiao J, Adkinson JA, Myers J, Allawala AB, Mathura RK, Pirtle V, Najera R, Provenza NR, Bartoli E, Watrous AJ, Oswalt D, Gadot R, Anand A, Shofty B, Mathew SJ, Goodman WK, Pouratian N, Pitkow X, Bijanki KR, Hayden B, Sheth SA. Xiao J, et al. Nat Commun. 2024 Jul 15;15(1):5528. doi: 10.1038/s41467-024-49600-7. Nat Commun. 2024. PMID: 39009561 Free PMC article.
Sex differences in heat stress vulnerability among middle-aged and older adults (PSU HEAT project).
Leach OK, Cottle RM, Fisher KG, Wolf ST, Kenney WL. Leach OK, et al. Am J Physiol Regul Integr Comp Physiol. 2024 Jul 15. doi: 10.1152/ajpregu.00114.2024. Online ahead of print. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 39005081
Individuals over the age of 65 are the most vulnerable population during severe environmental heat events, experiencing worse health outcomes than any other age cohort. The risk is greater in older women than in age-matched men; however, whether that reflects a greater sus …
Individuals over the age of 65 are the most vulnerable population during severe environmental heat events, experiencing worse health
DropBlot: single-cell western blotting of chemically fixed cancer cells.
Liu Y, Herr AE. Liu Y, et al. Nat Commun. 2024 Jul 13;15(1):5888. doi: 10.1038/s41467-024-50046-0. Nat Commun. 2024. PMID: 39003254 Free PMC article.
Relevant to biorepositories, DropBlot profiled targets retrieved from human-derived breast tumor specimens archived for six years, offering a workflow for single-cell protein-biomarker analysis of sparing biospecimens....
Relevant to biorepositories, DropBlot profiled targets retrieved from human-derived breast tumor specimens archived for six years, of …
Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics.
Weinreb C, Pearl JE, Lin S, Osman MAM, Zhang L, Annapragada S, Conlin E, Hoffmann R, Makowska S, Gillis WF, Jay M, Ye S, Mathis A, Mathis MW, Pereira T, Linderman SW, Datta SR. Weinreb C, et al. Nat Methods. 2024 Jul;21(7):1329-1339. doi: 10.1038/s41592-024-02318-2. Epub 2024 Jul 12. Nat Methods. 2024. PMID: 38997595 Free PMC article.
Here we present keypoint-MoSeq, a machine learning-based platform for identifying behavioral modules ('syllables') from keypoint data without human supervision. Keypoint-MoSeq uses a generative model to distinguish keypoint noise from behavior, enabling it to identify syll …
Here we present keypoint-MoSeq, a machine learning-based platform for identifying behavioral modules ('syllables') from keypoint data withou …
Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA.
Reautschnig P, Fruhner C, Wahn N, Wiegand CP, Kragness S, Yung JF, Hofacker DT, Fisk J, Eidelman M, Waffenschmidt N, Feige M, Pfeiffer LS, Schulz AE, Füll Y, Levanon EY, Mandel G, Stafforst T. Reautschnig P, et al. Nat Biotechnol. 2024 Jul 12. doi: 10.1038/s41587-024-02313-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38997581
The neural network RTNet exhibits the signatures of human perceptual decision-making.
Rafiei F, Shekhar M, Rahnev D. Rafiei F, et al. Nat Hum Behav. 2024 Jul 12. doi: 10.1038/s41562-024-01914-8. Online ahead of print. Nat Hum Behav. 2024. PMID: 38997452
To test RTNet's ability to predict human behaviour on novel images, we collected accuracy, RT and confidence data from 60 human participants performing a digit discrimination task. We found that the accuracy, RT and confidence produced by RTNet for individual novel …
To test RTNet's ability to predict human behaviour on novel images, we collected accuracy, RT and confidence data from 60 human
Interplay of Race and Neighborhood Deprivation on Resting and Ambulatory Blood Pressure in Young Adults.
Jeong S, Linder BA, Barnett AM, Tharpe MA, Hutchison ZJ, Culver MN, Sanchez SO, Nichols OI, Grosicki GJ, Bunsawat K, Nasci VL, Gohar EY, Fuller-Rowell TE, Robinson AT. Jeong S, et al. Am J Physiol Heart Circ Physiol. 2024 Jul 12. doi: 10.1152/ajpheart.00726.2023. Online ahead of print. Am J Physiol Heart Circ Physiol. 2024. PMID: 38995211
Neighborhood deprivation may contribute to disparities in cardiovascular health, but its effects on resting and ambulatory BP patterns in young adults is unclear. ...
Neighborhood deprivation may contribute to disparities in cardiovascular health, but its effects on resting and ambulatory BP pattern …
Utilizing connectome fingerprinting functional MRI models for motor activity prediction in presurgical planning: A feasibility study.
Tripathi V, Rigolo L, Bracken BK, Galvin CP, Golby AJ, Tie Y, Somers DC. Tripathi V, et al. Hum Brain Mapp. 2024 Jul 15;45(10):e26764. doi: 10.1002/hbm.26764. Hum Brain Mapp. 2024. PMID: 38994667 Free PMC article.
Here we utilized CF to train models on high-quality data from 208 subjects in the Human Connectome Project (HCP) and used this to predict task activations in our cohort of healthy control subjects (n = 15) and presurgical patients (n = 16) using resting-state fMRI (rs-fMRI …
Here we utilized CF to train models on high-quality data from 208 subjects in the Human Connectome Project (HCP) and used this to pre …
Insights from an N3C RECOVER EHR-based cohort study characterizing SARS-CoV-2 reinfections and Long COVID.
Hadley E, Yoo YJ, Patel S, Zhou A, Laraway B, Wong R, Preiss A, Chew R, Davis H, Brannock MD, Chute CG, Pfaff ER, Loomba J, Haendel M, Hill E; N3C and RECOVER consortia; Moffitt R. Hadley E, et al. Commun Med (Lond). 2024 Jul 11;4(1):129. doi: 10.1038/s43856-024-00539-2. Commun Med (Lond). 2024. PMID: 38992084 Free PMC article.
We aim to characterize reinfection, understand development of Long COVID after reinfection, and compare severity of reinfection with initial infection. METHODS: We use an electronic health record study cohort of over 3 million patients from the National COVID Cohort Collab …
We aim to characterize reinfection, understand development of Long COVID after reinfection, and compare severity of reinfection with initial …
Precision arbovirus serology with a pan-arbovirus peptidome.
Morgenlander WR, Chia WN, Parra B, Monaco DR, Ragan I, Pardo CA, Bowen R, Zhong D, Norris DE, Ruczinski I, Durbin A, Wang LF, Larman HB, Robinson ML. Morgenlander WR, et al. Nat Commun. 2024 Jul 11;15(1):5833. doi: 10.1038/s41467-024-49461-0. Nat Commun. 2024. PMID: 38992033 Free PMC article.
Arthropod-borne viruses represent a crucial public health threat. Current arboviral serology assays are either labor intensive or incapable of distinguishing closely related viruses, and many zoonotic arboviruses that may transition to humans lack any serologic assays. In …
Arthropod-borne viruses represent a crucial public health threat. Current arboviral serology assays are either labor intensive or inc …
Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase.
Nova IC, Craig JM, Mazumder A, Laszlo AH, Derrington IM, Noakes MT, Brinkerhoff H, Yang S, Vahedian-Movahed H, Li L, Zhang Y, Bowman JL, Huang JR, Mount JW, Ebright RH, Gundlach JH. Nova IC, et al. Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2321017121. doi: 10.1073/pnas.2321017121. Epub 2024 Jul 11. Proc Natl Acad Sci U S A. 2024. PMID: 38990947
Caregiver Experiences With an Internet-Delivered Insomnia Intervention: SHUTi-CARE Trial Primary Qualitative Analysis.
Shaffer KM, Perepezko K, Glazer JV, Mattos MK, Klinger J, Buysse DJ, Ritterband LM, Donovan H. Shaffer KM, et al. Ann Behav Med. 2024 Jul 11:kaae041. doi: 10.1093/abm/kaae041. Online ahead of print. Ann Behav Med. 2024. PMID: 38990523
BACKGROUND: Digital health interventions show potential to increase caregivers' access to psychosocial care; however, it is unclear to what extent existing interventions may need to be tailored to meet caregivers' unique needs. ...Future research should explore how such ta …
BACKGROUND: Digital health interventions show potential to increase caregivers' access to psychosocial care; however, it is unclear t …
Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing.
Reedy JL, Jensen KN, Crossen AJ, Basham KJ, Ward RA, Reardon CM, Brown Harding H, Hepworth OW, Simaku P, Kwaku GN, Tone K, Willment JA, Reid DM, Stappers MHT, Brown GD, Rajagopal J, Vyas JM. Reedy JL, et al. Nat Commun. 2024 Jul 10;15(1):5817. doi: 10.1038/s41467-024-50100-x. Nat Commun. 2024. PMID: 38987270 Free PMC article.
Respiratory infections caused by the human fungal pathogen Aspergillus fumigatus are a major cause of mortality for immunocompromised patients. Exposure to these pathogens occurs through inhalation, although the role of the respiratory epithelium in disease pathogenesis ha …
Respiratory infections caused by the human fungal pathogen Aspergillus fumigatus are a major cause of mortality for immunocompromised …
Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records.
Venkatesh SS, Ganjgahi H, Palmer DS, Coley K, Linchangco GV Jr, Hui Q, Wilson P, Ho YL, Cho K, Arumäe K; Million Veteran Program; Estonian Biobank Research Team; Wittemans LBL, Nellåker C, Vainik U, Sun YV, Holmes C, Lindgren CM, Nicholson G. Venkatesh SS, et al. Nat Commun. 2024 Jul 10;15(1):5801. doi: 10.1038/s41467-024-49998-0. Nat Commun. 2024. PMID: 38987242 Free PMC article.
We derive adiposity-change phenotypes from 24.5 million primary-care health records in over 740,000 individuals in the UK Biobank, Million Veteran Program USA, and Estonian Biobank, to discover and validate the genetic architecture of adiposity trajectories. ...
We derive adiposity-change phenotypes from 24.5 million primary-care health records in over 740,000 individuals in the UK Biobank, Mi …
Estimation of joint torque in dynamic activities using wearable A-mode ultrasound.
Jin Y, Alvarez JT, Suitor EL, Swaminathan K, Chin A, Civici US, Nuckols RW, Howe RD, Walsh CJ. Jin Y, et al. Nat Commun. 2024 Jul 9;15(1):5756. doi: 10.1038/s41467-024-50038-0. Nat Commun. 2024. PMID: 38982087 Free PMC article.
The human body constantly experiences mechanical loading. However, quantifying internal loads within the musculoskeletal system remains challenging, especially during unconstrained dynamic activities. ...
The human body constantly experiences mechanical loading. However, quantifying internal loads within the musculoskeletal system remai …
Sex differences in cardiac transcriptomic response to neonatal sleep apnea.
Cheung EC, Nilsson A, Venter I, Kowalik G, Ribeiro C, Rodriguez J, Kuraoka K, Russo R, Escobar JB, Alber BR, Mendelowitz D, Kay MW, Schunke KJ. Cheung EC, et al. Physiol Rep. 2024 Jul;12(13):e16110. doi: 10.14814/phy2.16110. Physiol Rep. 2024. PMID: 38981849 Free PMC article.
Pediatric obstructive sleep apnea poses a significant health risk, with potential long-term consequences on cardiovascular health. ...
Pediatric obstructive sleep apnea poses a significant health risk, with potential long-term consequences on cardiovascular health
Exercise as a tool to mitigate metabolic disease.
Esteves JV, Stanford KI. Esteves JV, et al. Am J Physiol Cell Physiol. 2024 Jul 9. doi: 10.1152/ajpcell.00144.2024. Online ahead of print. Am J Physiol Cell Physiol. 2024. PMID: 38981607 Review.
Metabolic diseases, notably obesity and type 2 diabetes, have reached alarming proportions and constitute a significant global health challenge, emphasizing the urgent need for effective preventive and therapeutic strategies. In contrast, exercise training emerges as a pot …
Metabolic diseases, notably obesity and type 2 diabetes, have reached alarming proportions and constitute a significant global health
Characterization of chronic pain, pain interference, and daily pain experiences in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.
Alberts NM, Leisenring W, Whitton J, Stratton K, Jibb L, Flynn J, Pizzo A, Brinkman TM, Birnie K, Gibson TM, McDonald A, Ford J, Olgin JE, Nathan PC, Stinson JN, Armstrong GT. Alberts NM, et al. Pain. 2024 Jul 9. doi: 10.1097/j.pain.0000000000003284. Online ahead of print. Pain. 2024. PMID: 38981063
Chronic pain was associated with previous intravenous methotrexate treatment (PR = 1.6, 95% CI 1.1-2.3), respiratory (PR = 1.8, 95% CI 1.2-2.5), gastrointestinal (PR = 1.6, 95% CI 11.0-2.3), and neurological (PR = 1.5, 95% CI 1.0-2.1) chronic health conditions, unemploymen …
Chronic pain was associated with previous intravenous methotrexate treatment (PR = 1.6, 95% CI 1.1-2.3), respiratory (PR = 1.8, 95% CI 1.2-2 …
Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release.
Liu Z, Li S, Wang C, Vidmar KJ, Bracey S, Li L, Willard B, Miyagi M, Lan T, Dickinson BC, Osme A, Pizarro TT, Xiao TS. Liu Z, et al. Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2400883121. doi: 10.1073/pnas.2400883121. Epub 2024 Jul 9. Proc Natl Acad Sci U S A. 2024. PMID: 38980908
Previous work characterized S-palmitoylation for gasdermins from bacteria, fungi, invertebrates, as well as mammalian gasdermin E (GSDME). Here, we report that a conserved residue Cys191 in human GSDMD was S-palmitoylated, which promoted GSDMD-mediated pyroptosis and cytok …
Previous work characterized S-palmitoylation for gasdermins from bacteria, fungi, invertebrates, as well as mammalian gasdermin E (GSDME). H …
CD39 Is Expressed on Functional Effector and Tissue-resident Memory CD8+ T Cells.
Isaacs JF, Degefu HN, Chen T, Kleist SA, Musial SC, Ford MA, Searles TG, Lin CC, Skorput AGJ, Shirai K, Turk MJ, Zanazzi GJ, Rosato PC. Isaacs JF, et al. J Immunol. 2024 Jul 8:ji2400151. doi: 10.4049/jimmunol.2400151. Online ahead of print. J Immunol. 2024. PMID: 38975728
The enriched MPEC phenotype is associated with enhanced tissue resident memory T cell (TRM cell) establishment in the brain and salivary gland following an acute intranasal viral infection, suggesting that CD39 ATPase activity plays a role in memory CD8+ T cell differentiation. W …
The enriched MPEC phenotype is associated with enhanced tissue resident memory T cell (TRM cell) establishment in the brain and salivary gla …
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools.
Pezacki AT, Gonciarz RL, Okamura T, Matier CD, Torrente L, Cheng K, Miller SG, Ralle M, Ward NP, DeNicola GM, Renslo AR, Chang CJ. Pezacki AT, et al. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2401579121. doi: 10.1073/pnas.2401579121. Epub 2024 Jul 5. Proc Natl Acad Sci U S A. 2024. PMID: 38968123 Free PMC article.
By connecting labile iron pools and NRF2-ARE activity to a druggable metal-dependent vulnerability in cancer, this work provides a starting point for broader investigations into the roles of transition metal and antioxidant signaling pathways in health and disease....
By connecting labile iron pools and NRF2-ARE activity to a druggable metal-dependent vulnerability in cancer, this work provides a starting …
Development of a sexual consent intervention for adolescents with intellectual and developmental disabilities.
Greene A, Baugh M, Sherwood-Laughlin C, Greathouse L, Galyan J, Simic Stanjovic I, Sangmo D, Jozkowski K, Dubie M, Chow A. Greene A, et al. J Appl Res Intellect Disabil. 2024 Sep;37(5):e13272. doi: 10.1111/jar.13272. J Appl Res Intellect Disabil. 2024. PMID: 38966968
This paper presents the development of an intervention framework to address equity in sexuality education and support adolescents with intellectual and developmental disabilities to understand and provide sexual consent, a foundational aspect of sexuality education and sexual …
This paper presents the development of an intervention framework to address equity in sexuality education and support adolescents with intel …
Harnessing EHR data for health research.
Tang AS, Woldemariam SR, Miramontes S, Norgeot B, Oskotsky TT, Sirota M. Tang AS, et al. Nat Med. 2024 Jul;30(7):1847-1855. doi: 10.1038/s41591-024-03074-8. Epub 2024 Jul 4. Nat Med. 2024. PMID: 38965433 Review.
With the increasing availability of rich, longitudinal, real-world clinical data recorded in electronic health records (EHRs) for millions of patients, there is a growing interest in leveraging these records to improve the understanding of human health and di …
With the increasing availability of rich, longitudinal, real-world clinical data recorded in electronic health records (EHRs) for mil …
LINE1 mediates long-range DNA interactions.
Liang Y, Wang T. Liang Y, et al. Nat Genet. 2024 Jul;56(7):1328-1330. doi: 10.1038/s41588-024-01824-5. Nat Genet. 2024. PMID: 38965415 No abstract available.
Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids.
LeSavage BL, Zhang D, Huerta-López C, Gilchrist AE, Krajina BA, Karlsson K, Smith AR, Karagyozova K, Klett KC, Huang MS, Long C, Kaber G, Madl CM, Bollyky PL, Curtis C, Kuo CJ, Heilshorn SC. LeSavage BL, et al. Nat Mater. 2024 Jul 4. doi: 10.1038/s41563-024-01908-x. Online ahead of print. Nat Mater. 2024. PMID: 38965405
Overall, our findings support the potential of engineered matrices and patient-derived organoids for elucidating extracellular matrix contributions to human disease pathophysiology....
Overall, our findings support the potential of engineered matrices and patient-derived organoids for elucidating extracellular matrix contri …
Recruitment of FBXO22 for targeted degradation of NSD2.
Nie DY, Tabor JR, Li J, Kutera M, St-Germain J, Hanley RP, Wolf E, Paulakonis E, Kenney TMG, Duan S, Shrestha S, Owens DDG, Maitland MER, Pon A, Szewczyk M, Lamberto AJ, Menes M, Li F, Penn LZ, Barsyte-Lovejoy D, Brown NG, Barsotti AM, Stamford AW, Collins JL, Wilson DJ, Raught B, Licht JD, James LI, Arrowsmith CH. Nie DY, et al. Nat Chem Biol. 2024 Jul 4. doi: 10.1038/s41589-024-01660-y. Online ahead of print. Nat Chem Biol. 2024. PMID: 38965384
Prospective longitudinal relations among frequent social media use, nicotine vaping and experiencing internalizing mental health problems.
Lee S, Elam K, Lohrmann D, Luo J, Chow A, Seo DC. Lee S, et al. Addiction. 2024 Jul 3. doi: 10.1111/add.16601. Online ahead of print. Addiction. 2024. PMID: 38961689
AIMS: To compare four a priori rival mediated pathways of frequent social media use, electronic nicotine delivery systems (ENDS) use and internalizing mental health (MH) problems across five waves of nationally representative data. ...Sex differences did not emerge …
AIMS: To compare four a priori rival mediated pathways of frequent social media use, electronic nicotine delivery systems (ENDS) use …
Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective.
Zhang Y, Chamblee M, Xu J, Qu P, Shamseldin MM, Yoo SJ, Misny J, Thongpan I, Kc M, Hall JM, Gupta YA, Evans JP, Lu M, Ye C, Hsu CC, Liang X, Martinez-Sobrido L, Yount JS, Boyaka PN, Liu SL, Dubey P, Peeples ME, Li J. Zhang Y, et al. Nat Commun. 2024 Jul 3;15(1):5589. doi: 10.1038/s41467-024-49443-2. Nat Commun. 2024. PMID: 38961063 Free PMC article.
The genome-wide signature of short-term temporal selection.
Lynch M, Wei W, Ye Z, Pfrender M. Lynch M, et al. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2307107121. doi: 10.1073/pnas.2307107121. Epub 2024 Jul 3. Proc Natl Acad Sci U S A. 2024. PMID: 38959040
Precision Mapping of the Default Network Reveals Common and Distinct (Inter)activity for Autobiographical Memory and Theory of Mind.
Hughes C, Setton R, Mwilambwe-Tshilobo L, Baracchini G, Turner GR, Spreng RN. Hughes C, et al. J Neurophysiol. 2024 Jul 3. doi: 10.1152/jn.00427.2023. Online ahead of print. J Neurophysiol. 2024. PMID: 38958281
Our results support that autobiographical memory and theory of mind - two theoretically important and widely-studied domains of social cognition - evoke common and distinct aspects of the default network even when ensuring high fidelity to individual-specific characteristi …
Our results support that autobiographical memory and theory of mind - two theoretically important and widely-studied domains of social
Cultural, demographic, and other non-demographic factors associated with cancer genetic counseling patients' appointment accompaniment preferences in the United States.
Lin J, Cantor RM, Niell-Swiller M, Sayegh P, Palmer CGS. Lin J, et al. J Genet Couns. 2024 Jul 2. doi: 10.1002/jgc4.1942. Online ahead of print. J Genet Couns. 2024. PMID: 38956816
A link to an online questionnaire was emailed to patients who met four criteria: (1) identified as either Hispanic/Latine or non-Hispanic/Latine White; (2) had attended a cancer genetic counseling appointment at UCLA Health to discuss genetic testing options between Octobe …
A link to an online questionnaire was emailed to patients who met four criteria: (1) identified as either Hispanic/Latine or non-Hispanic/La …
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction.
Zhang P, Munier JJ, Wiese CB, Vergnes L, Link JC, Abbasi F, Ronquillo E, Scheker K, Muñoz A, Kuang YL, Theusch E, Lu M, Sanchez G, Oni-Orisan A, Iribarren C, McPhaul MJ, Nomura DK, Knowles JW, Krauss RM, Medina MW, Reue K. Zhang P, et al. Nat Commun. 2024 Jul 2;15(1):5571. doi: 10.1038/s41467-024-49764-2. Nat Commun. 2024. PMID: 38956041 Free PMC article.
Perirhinal cortex learns a predictive map of the task environment.
Lee DG, McLachlan CA, Nogueira R, Kwon O, Carey AE, House G, Lagani GD, LaMay D, Fusi S, Chen JL. Lee DG, et al. Nat Commun. 2024 Jul 2;15(1):5544. doi: 10.1038/s41467-024-47365-7. Nat Commun. 2024. PMID: 38956015 Free PMC article.
Machine learning-based classification reveals distinct clusters of non-coding genomic allelic variations associated with Erm-mediated antibiotic resistance.
Tan Y, Scornet AL, Yap M-NF, Zhang D. Tan Y, et al. mSystems. 2024 Jul 23;9(7):e0043024. doi: 10.1128/msystems.00430-24. Epub 2024 Jul 2. mSystems. 2024. PMID: 38953319 Free PMC article.
Taken together, this study not only elucidates the evolutionary processes driving the emergence and development of MLS resistance but also highlights the potential of using non-coding genomic allele data to predict antibiotic resistance phenotypes. IMPORTANCE: Antibiotic resistan …
Taken together, this study not only elucidates the evolutionary processes driving the emergence and development of MLS resistance but also h …
Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions.
Karnam Y, Mut F, Yu AK, Cheng B, Amin-Hanjani S, Charbel FT, Woo HH, Niemelä M, Tulamo R, Jahromi BR, Frösen J, Tobe Y, Robertson AM, Cebral JR. Karnam Y, et al. Int J Numer Method Biomed Eng. 2024 Jul 1:e3844. doi: 10.1002/cnm.3844. Online ahead of print. Int J Numer Method Biomed Eng. 2024. PMID: 38952068
Intracranial aneurysms (IAs) pose severe health risks influenced by hemodynamics. This study focuses on the intricate characterization of hemodynamic conditions within the IA walls and their influence on bleb development, aiming to enhance understanding of aneurysm stabili …
Intracranial aneurysms (IAs) pose severe health risks influenced by hemodynamics. This study focuses on the intricate characterizatio …
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy.
Duarte JD, Thomas CD, Lee CR, Huddart R, Agundez JAG, Baye JF, Gaedigk A, Klein TE, Lanfear DE, Monte AA, Nagy M, Schwab M, Stein CM, Uppugunduri CRS, van Schaik RHN, Donnelly RS, Caudle KE, Luzum JA. Duarte JD, et al. Clin Pharmacol Ther. 2024 Jul 1. doi: 10.1002/cpt.3351. Online ahead of print. Clin Pharmacol Ther. 2024. PMID: 38951961 Review.
Structural basis for Mis18 complex assembly and its implications for centromere maintenance.
Thamkachy R, Medina-Pritchard B, Park SH, Chiodi CG, Zou J, de la Torre-Barranco M, Shimanaka K, Abad MA, Gallego Páramo C, Feederle R, Ruksenaite E, Heun P, Davies OR, Rappsilber J, Schneidman-Duhovny D, Cho US, Jeyaprakash AA. Thamkachy R, et al. EMBO Rep. 2024 Jul 1. doi: 10.1038/s44319-024-00183-w. Online ahead of print. EMBO Rep. 2024. PMID: 38951710 Free article.
Time of sample collection is critical for the replicability of microbiome analyses.
Allaband C, Lingaraju A, Flores Ramos S, Kumar T, Javaheri H, Tiu MD, Dantas Machado AC, Richter RA, Elijah E, Haddad GG, Leone VA, Dorrestein PC, Knight R, Zarrinpar A. Allaband C, et al. Nat Metab. 2024 Jul 1. doi: 10.1038/s42255-024-01064-1. Online ahead of print. Nat Metab. 2024. PMID: 38951660
The role of positive emotion in harmful health behavior: Implications for theory and public health campaigns.
Wang K, Rees VW, Dorison CA, Kawachi I, Lerner JS. Wang K, et al. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2320750121. doi: 10.1073/pnas.2320750121. Epub 2024 Jul 1. Proc Natl Acad Sci U S A. 2024. PMID: 38950367
Together, our studies advance understanding of positive emotion effects on appetitive risk behaviors; they also offer practical implications for the design of public health campaigns....
Together, our studies advance understanding of positive emotion effects on appetitive risk behaviors; they also offer practical implications …
Growing three-dimensional objects with light.
Lipkowitz G, Saccone MA, Panzer MA, Coates IA, Hsiao K, Ilyn D, Kronenfeld JM, Tumbleston JR, Shaqfeh ESG, DeSimone JM. Lipkowitz G, et al. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2303648121. doi: 10.1073/pnas.2303648121. Epub 2024 Jul 1. Proc Natl Acad Sci U S A. 2024. PMID: 38950359
Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research.
Wright EC, Scott E, Tian L. Wright EC, et al. Neuropsychopharmacology. 2024 Jun 28. doi: 10.1038/s41386-024-01903-5. Online ahead of print. Neuropsychopharmacology. 2024. PMID: 38942957 Review.
Psychiatric research encompasses diverse methodologies to understand the complex interplay between neurochemistry and behavior in mental health disorders. Despite significant advancements in pharmacological interventions, there remains a critical gap in understanding the p …
Psychiatric research encompasses diverse methodologies to understand the complex interplay between neurochemistry and behavior in mental …
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
Neyton LPA, Patel RK, Sarma A; UCSF COMET Consortium; Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK. Neyton LPA, et al. Nat Commun. 2024 Jun 28;15(1):5483. doi: 10.1038/s41467-024-49756-2. Nat Commun. 2024. PMID: 38942804 Free PMC article.
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus.
Pellerin D, Del Gobbo GF, Couse M, Dolzhenko E, Nageshwaran SK, Cheung WA, Xu IRL, Dicaire MJ, Spurdens G, Matos-Rodrigues G, Stevanovski I, Scriba CK, Rebelo A, Roth V, Wandzel M, Bonnet C, Ashton C, Agarwal A, Peter C, Hasson D, Tsankova NM, Dewar K, Lamont PJ, Laing NG, Renaud M, Houlden H, Synofzik M, Usdin K, Nussenzweig A, Napierala M, Chen Z, Jiang H, Deveson IW, Ravenscroft G, Akbarian S, Eberle MA, Boycott KM, Pastinen T; All of Us Research Program Long Read Working Group; Brais B, Zuchner S, Danzi MC. Pellerin D, et al. Nat Genet. 2024 Jul;56(7):1366-1370. doi: 10.1038/s41588-024-01808-5. Epub 2024 Jun 27. Nat Genet. 2024. PMID: 38937606
A sensory-motor theory of the neocortex.
Rao RPN. Rao RPN. Nat Neurosci. 2024 Jul;27(7):1221-1235. doi: 10.1038/s41593-024-01673-9. Epub 2024 Jun 27. Nat Neurosci. 2024. PMID: 38937581 Review.
Zinc and pH modulate the ability of insulin to inhibit aggregation of islet amyloid polypeptide.
McCalpin SD, Khemtemourian L, Suladze S, Ivanova MI, Reif B, Ramamoorthy A. McCalpin SD, et al. Commun Biol. 2024 Jun 27;7(1):776. doi: 10.1038/s42003-024-06388-y. Commun Biol. 2024. PMID: 38937578 Free PMC article.
Aggregation of the human islet amyloid polypeptide (hIAPP) contributes to the development and progression of Type 2 Diabetes (T2D). hIAPP aggregates within a few hours at few micromolar concentration in vitro but exists at millimolar concentrations in vivo. ...
Aggregation of the human islet amyloid polypeptide (hIAPP) contributes to the development and progression of Type 2 Diabetes (T2D). h …
Data-driven prediction of continuous renal replacement therapy survival.
Zamanzadeh D, Feng J, Petousis P, Vepa A, Sarrafzadeh M, Karumanchi SA, Bui AAT, Kurtz I. Zamanzadeh D, et al. Nat Commun. 2024 Jun 27;15(1):5440. doi: 10.1038/s41467-024-49763-3. Nat Commun. 2024. PMID: 38937447 Free PMC article.
To address these issues, we present a machine learning-based algorithm to predict short-term survival in patients being initiated on CRRT. We use information extracted from electronic health records from patients who were placed on CRRT at multiple institutions to train a …
To address these issues, we present a machine learning-based algorithm to predict short-term survival in patients being initiated on CRRT. W …
An integrated metaproteomics workflow for studying host-microbe dynamics in bronchoalveolar lavage samples applied to cystic fibrosis disease.
Kruk ME, Mehta S, Murray K, Higgins L, Do K, Johnson JE, Wagner R, Wendt CH, O'Connor JB, Harris JK, Laguna TA, Jagtap PD, Griffin TJ. Kruk ME, et al. mSystems. 2024 Jul 23;9(7):e0092923. doi: 10.1128/msystems.00929-23. Epub 2024 Jun 27. mSystems. 2024. PMID: 38934598 Free PMC article.
Label-free quantification revealed differentially abundant human peptides from proteins with known roles in CF, like neutrophil elastase and collagenase, and proteins with lesser-known roles in CF, including apolipoproteins. ...To this end, characterizing the proteins expr …
Label-free quantification revealed differentially abundant human peptides from proteins with known roles in CF, like neutrophil elast …
Hepatitis B Virus Prevalence among HIV-Uninfected People Living in Rural and Peri-Urban Areas in Botswana.
Anderson M, Mangogola T, Phinius BB, Mpebe G, Aimakhu CO, Choga WT, Phakedi B, Bhebhe LN, Ditshwanelo D, Baruti K, Mpofu-Dobo L, Othusitse L, Ratsoma T, Gaolathe T, Makhema J, Shapiro R, Lockman S, Moyo S, Gaseitsiwe S. Anderson M, et al. Microorganisms. 2024 Jun 15;12(6):1207. doi: 10.3390/microorganisms12061207. Microorganisms. 2024. PMID: 38930589 Free PMC article.
(1) Background: we determined the prevalence of the hepatitis B virus (HBV) amongst people without human immunodeficiency virus (HIV) in rural and peri-urban areas in Botswana. (2) Methods: We screened for the hepatitis B surface antigen (HBsAg) from archived plasma sample …
(1) Background: we determined the prevalence of the hepatitis B virus (HBV) amongst people without human immunodeficiency virus (HIV) …
Predictability of buprenorphine-naloxone treatment retention: A multi-site analysis combining electronic health records and machine learning.
Nateghi Haredasht F, Fouladvand S, Tate S, Chan MM, Yeow JJL, Griffiths K, Lopez I, Bertz JW, Miner AS, Hernandez-Boussard T, Chen CA, Deng H, Humphreys K, Lembke A, Vance LA, Chen JH. Nateghi Haredasht F, et al. Addiction. 2024 Jun 24. doi: 10.1111/add.16587. Online ahead of print. Addiction. 2024. PMID: 38923168
Our objective was to determine the predictability of 6-month retention in buprenorphine-naloxone treatment using electronic health record (EHR) data from diverse clinical settings and to identify key predictors. ...CONCLUSIONS: US patients with opioid use disorder or opioi …
Our objective was to determine the predictability of 6-month retention in buprenorphine-naloxone treatment using electronic health re …
Concept Mapping STI/HIV Prevention and Condom Use among Young African American Adults.
Carmack C, Nganga S, Ahmed E, Coleman T. Carmack C, et al. Behav Sci (Basel). 2024 Jun 14;14(6):501. doi: 10.3390/bs14060501. Behav Sci (Basel). 2024. PMID: 38920833 Free PMC article.
Seven overall conceptual domains emerged: self-efficacy for partner communication, condom use self-efficacy, social media/sociocultural influences, condom use/STI knowledge, condom use cons, condom use pros, and subjective and social norms about condom use. We prese …
Seven overall conceptual domains emerged: self-efficacy for partner communication, condom use self-efficacy, social media/sociocultur …
S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis.
Brunner HI, Schulert GS, Sproles A, Thornton S, Cornejo GV, Antón J, Cuttica R, Henrickson M, Foeldvari I, Kingsbury DJ, Askelson M, Liu J, Mukherjee S, Wong RL, Lovell DJ, Martini A, Ruperto N, Grom AA; Pediatric Rheumatology Collaborative Study Group (PRCSG) and the Paediatric Rheumatology International Trials Organisation (PRINTO). Brunner HI, et al. Arthritis Res Ther. 2024 Jun 25;26(1):125. doi: 10.1186/s13075-024-03347-0. Arthritis Res Ther. 2024. PMID: 38918871 Free PMC article. Clinical Trial.
Physiological regulation of neuronal Wnt activity is essential for TDP-43 localization and function.
Zhang N, Westerhaus A, Wilson M, Wang E, Goff L, Sockanathan S. Zhang N, et al. EMBO J. 2024 Jun 25. doi: 10.1038/s44318-024-00156-8. Online ahead of print. EMBO J. 2024. PMID: 38918634 Free article.
Disruption of GDE2 coincides with TDP-43 abnormalities in postmortem tissue from patients with amyotrophic lateral sclerosis (ALS). Further, GDE2 deficits are evident in human neural cell models of ALS, which display erroneous Wnt activation that, when inhibited, increases …
Disruption of GDE2 coincides with TDP-43 abnormalities in postmortem tissue from patients with amyotrophic lateral sclerosis (ALS). Further, …
In vivo AAV-SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy.
Peng L, Renauer PA, Sferruzza G, Yang L, Zou Y, Fang Z, Park JJ, Chow RD, Zhang Y, Lin Q, Bai M, Sanchez A, Zhang Y, Lam SZ, Ye L, Chen S. Peng L, et al. Nat Biotechnol. 2024 Jun 25. doi: 10.1038/s41587-024-02282-4. Online ahead of print. Nat Biotechnol. 2024. PMID: 38918616
As a convergent hit, CALHM2-knockout (KO) NK cells showed enhanced cytotoxicity and tumor infiltration in mouse primary NK cells and human chimeric antigen receptor (CAR)-NK cells. CALHM2 mRNA reversed the CALHM2-KO phenotype. CALHM2 KO in human primary NK cells enh …
As a convergent hit, CALHM2-knockout (KO) NK cells showed enhanced cytotoxicity and tumor infiltration in mouse primary NK cells and huma
Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes.
Grodner B, Shi H, Farchione O, Vill AC, Ntekas I, Diebold PJ, Wu DT, Chen CY, Kim DM, Zipfel WR, Brito IL, De Vlaminck I. Grodner B, et al. Nat Microbiol. 2024 Jun 25. doi: 10.1038/s41564-024-01735-5. Online ahead of print. Nat Microbiol. 2024. PMID: 38918467
We spatially mapped bacteriophage and antimicrobial resistance (AMR) plasmids and identified their host taxa in human oral biofilms. This revealed distinct clusters of AMR plasmids and prophage, coinciding with densely packed regions of host bacteria. ...
We spatially mapped bacteriophage and antimicrobial resistance (AMR) plasmids and identified their host taxa in human oral biofilms. …
An all-atom protein generative model.
Chu AE, Kim J, Cheng L, El Nesr G, Xu M, Shuai RW, Huang PS. Chu AE, et al. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2311500121. doi: 10.1073/pnas.2311500121. Epub 2024 Jun 25. Proc Natl Acad Sci U S A. 2024. PMID: 38916999 Free PMC article.
The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto-N-acyl amides with inhibitory activity against mutualistic host nematode egg hatching.
Lam YC, Hamchand R, Mucci NC, Kauffman SJ, Dudkina N, Reagle EV, Casanova-Torres ÁM, DeCuyper J, Chen H, Song D, Thomas MG, Palm NW, Goodrich-Blair H, Crawford JM. Lam YC, et al. Appl Environ Microbiol. 2024 Jul 24;90(7):e0052824. doi: 10.1128/aem.00528-24. Epub 2024 Jun 25. Appl Environ Microbiol. 2024. PMID: 38916293
N-acyl amides 1 and 2 were shown to be selective agonists for the human G-protein-coupled receptors (GPCRs) C3AR1 and CHRM2, respectively. ...
N-acyl amides 1 and 2 were shown to be selective agonists for the human G-protein-coupled receptors (GPCRs) C3AR1 and CHRM2, respecti …
Microbial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut.
Quinn-Bohmann N, Wilmanski T, Sarmiento KR, Levy L, Lampe JW, Gurry T, Rappaport N, Ostrem EM, Venturelli OS, Diener C, Gibbons SM. Quinn-Bohmann N, et al. Nat Microbiol. 2024 Jul;9(7):1700-1712. doi: 10.1038/s41564-024-01728-4. Epub 2024 Jun 24. Nat Microbiol. 2024. PMID: 38914826
We evaluate the quantitative accuracy of our MCMMs using in vitro and ex vivo data, plus published human cohort data. We find that MCMM SCFA predictions are significantly associated with blood-derived clinical chemistries, including cardiometabolic and immunological hea
We evaluate the quantitative accuracy of our MCMMs using in vitro and ex vivo data, plus published human cohort data. We find that MC …
A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance.
Kane J, Li X, Kumar S, Button-Simons KA, Vendrely Brenneman KM, Dahlhoff H, Sievert MAC, Checkley LA, Shoue DA, Singh PP, Abatiyow BA, Haile MT, Nair S, Reyes A, Tripura R, Peto TJ, Lek D, Mukherjee A, Kappe SHI, Dhorda M, Nkhoma SC, Cheeseman IH, Vaughan AM, Anderson TJC, Ferdig MT. Kane J, et al. mBio. 2024 Jul 17;15(7):e0080524. doi: 10.1128/mbio.00805-24. Epub 2024 Jun 24. mBio. 2024. PMID: 38912775 Free PMC article.
The rRNA epitranscriptome and myonuclear SNORD landscape in skeletal muscle fibers contributes to ribosome heterogeneity and is altered by hypertrophic stimulus.
Cui M, Jannig P, Halladjian M, Figueiredo VC, Wen Y, Vechetti IJ Jr, Krogh N, Jude B, Edman S, Lanner J, McCarthy J, Murach KA, Sejersen T, Nielsen H, von Walden F. Cui M, et al. Am J Physiol Cell Physiol. 2024 Jun 24. doi: 10.1152/ajpcell.00301.2024. Online ahead of print. Am J Physiol Cell Physiol. 2024. PMID: 38912733 Free article.
Viral modulation of type II interferon increases T cell adhesion and virus spread.
Jacobsen C, Plückebaum N, Ssebyatika G, Beyer S, Mendes-Monteiro L, Wang J, Kropp KA, González-Motos V, Steinbrück L, Ritter B, Rodríguez-González C, Böning H, Nikolouli E, Kinchington PR, Lachmann N, Depledge DP, Krey T, Viejo-Borbolla A. Jacobsen C, et al. Nat Commun. 2024 Jun 22;15(1):5318. doi: 10.1038/s41467-024-49657-4. Nat Commun. 2024. PMID: 38909022 Free PMC article.
Widespread chromatin context-dependencies of DNA double-strand break repair proteins.
Vergara X, Manjón AG, de Haas M, Morris B, Schep R, Leemans C, Friskes A, Beijersbergen RL, Sanders MA, Medema RH, van Steensel B. Vergara X, et al. Nat Commun. 2024 Jun 22;15(1):5334. doi: 10.1038/s41467-024-49232-x. Nat Commun. 2024. PMID: 38909016 Free PMC article.
Examples of the former are BRCA2 and POLL, and of the latter the FANC complex and ATM. Moreover, in a diversity of human cancer types, loss of several of these proteins alters the distribution of pathway-specific mutations between heterochromatin and euchromatin. ...
Examples of the former are BRCA2 and POLL, and of the latter the FANC complex and ATM. Moreover, in a diversity of human cancer types …
Examining the creation of synergy in community coalitions for smoke-free environments in Armenia and Georgia.
Kegler MC, Hayrumyan V, Dekanosidze A, Grigoryan L, Torosyan A, Sargsyan Z, Sturua L, Bazarchyan A, Berg CJ. Kegler MC, et al. Health Promot Int. 2024 Jun 1;39(3):daae058. doi: 10.1093/heapro/daae058. Health Promot Int. 2024. PMID: 38907528
Community coalitions depend on their members to synergistically pool diverse resources, including knowledge and expertise, community connections and varied perspectives, to identify and implement strategies and make progress toward community health improvement. Several coa …
Community coalitions depend on their members to synergistically pool diverse resources, including knowledge and expertise, community connect …
The impact of astrocytic NF-κB on healthy and Alzheimer's disease brains.
Jong Huat T, Camats-Perna J, Newcombe EA, Onraet T, Campbell D, Sucic JT, Martini A, Forner S, Mirzaei M, Poon W, LaFerla FM, Medeiros R. Jong Huat T, et al. Sci Rep. 2024 Jun 21;14(1):14305. doi: 10.1038/s41598-024-65248-1. Sci Rep. 2024. PMID: 38906984 Free PMC article.
The transcriptional factor nuclear factor-kappaB (NF-kappaB) drives astrocyte diversity, but the mechanisms are not fully understood. By combining studies in human brains and animal models and selectively manipulating NF-kappaB function in astrocytes, we deepened the under …
The transcriptional factor nuclear factor-kappaB (NF-kappaB) drives astrocyte diversity, but the mechanisms are not fully understood. By com …
Targeting Chemoresistance in Advanced Bladder Cancers with a Novel Adjuvant Strategy.
Seremak JR, Gupta KB, Bonigala S, Liu E, Marshall B, Zhi W, Bokhtia RM, Panda SS, Lokeshwar VB, Lokeshwar BL. Seremak JR, et al. Mol Cancer Ther. 2024 Jun 21:OF1-OF15. doi: 10.1158/1535-7163.MCT-23-0806. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38904221
The therapeutic potential of a molecular hybrid of ursolic acid (UA), a pentacyclic-triterpene conjugated to N-methyl piperazine (UA4), was tested on both naive (WT) and gemcitabine-resistant (GemR) variants of two human invasive bladder cancer cell lines, 5637 and T24. UA …
The therapeutic potential of a molecular hybrid of ursolic acid (UA), a pentacyclic-triterpene conjugated to N-methyl piperazine (UA4), was …
Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL.
Wenzl K, Stokes ME, Novak JP, Bock AM, Khan S, Hopper MA, Krull JE, Dropik AR, Walker JS, Sarangi V, Mwangi R, Ortiz M, Stong N, Huang CC, Maurer MJ, Rimsza L, Link BK, Slager SL, Asmann Y, Mondello P, Morin R, Ansell SM, Habermann TM, Witzig TE, Feldman AL, King RL, Nowakowski G, Cerhan JR, Gandhi AK, Novak AJ. Wenzl K, et al. Blood Cancer J. 2024 Jun 20;14(1):100. doi: 10.1038/s41408-024-01080-0. Blood Cancer J. 2024. PMID: 38902256 Free PMC article.
Democratizing protein language models with parameter-efficient fine-tuning.
Sledzieski S, Kshirsagar M, Baek M, Dodhia R, Lavista Ferres J, Berger B. Sledzieski S, et al. Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2405840121. doi: 10.1073/pnas.2405840121. Epub 2024 Jun 20. Proc Natl Acad Sci U S A. 2024. PMID: 38900798 Free PMC article.
B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic Mycobacterium tuberculosis lung infection in Diversity Outbred mice.
Koyuncu D, Tavolara T, Gatti DM, Gower AC, Ginese ML, Kramnik I, Yener B, Sajjad U, Niazi MKK, Gurcan M, Alsharaydeh A, Beamer G. Koyuncu D, et al. Infect Immun. 2024 Jul 11;92(7):e0026323. doi: 10.1128/iai.00263-23. Epub 2024 Jun 20. Infect Immun. 2024. PMID: 38899881 Free PMC article.
Broadly protective bispecific antibodies that simultaneously target influenza virus hemagglutinin and neuraminidase.
Ramos KE, Okba NMA, Tan J, Bandawane P, Meade PS, Loganathan M, Francis B, Shulenin S, Holtsberg FW, Aman MJ, McMahon M, Krammer F, Lai JR. Ramos KE, et al. mBio. 2024 Jul 17;15(7):e0108524. doi: 10.1128/mbio.01085-24. Epub 2024 Jun 20. mBio. 2024. PMID: 38899870 Free PMC article.
IMPORTANCE: Infection by the influenza virus remains a global health burden. The approaches utilized here to augment the activity of broadly protective influenza virus antibodies may lead to a new class of immunotherapies with enhanced activity....
IMPORTANCE: Infection by the influenza virus remains a global health burden. The approaches utilized here to augment the activity of …
Channeling kynurenine.
Sweeney MI, Tobin DM. Sweeney MI, et al. Nat Chem Biol. 2024 Jun 19. doi: 10.1038/s41589-024-01643-z. Online ahead of print. Nat Chem Biol. 2024. PMID: 38898167 No abstract available.
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Xu S, Wang N, Zuccaro MV, Gerhardt J, Iyyappan R, Scatolin GN, Jiang Z, Baslan T, Koren A, Egli D. Xu S, et al. Nat Commun. 2024 Jun 19;15(1):5247. doi: 10.1038/s41467-024-49565-7. Nat Commun. 2024. PMID: 38898078 Free PMC article.
Chromosome breaks, which form spontaneously in bovine embryos at sites concordant with human embryos, preferentially locate to late replicating regions. ...
Chromosome breaks, which form spontaneously in bovine embryos at sites concordant with human embryos, preferentially locate to late r …
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.
Strongin Z, Raymond Marchand L, Deleage C, Pampena MB, Cardenas MA, Beusch CM, Hoang TN, Urban EA, Gourves M, Nguyen K, Tharp GK, Lapp S, Rahmberg AR, Harper J, Del Rio Estrada PM, Gonzalez-Navarro M, Torres-Ruiz F, Luna-Villalobos YA, Avila-Rios S, Reyes-Teran G, Sekaly R, Silvestri G, Kulpa DA, Saez-Cirion A, Brenchley JM, Bosinger SE, Gordon DE, Betts MR, Kissick HT, Paiardini M. Strongin Z, et al. Nat Immunol. 2024 Jul;25(7):1245-1256. doi: 10.1038/s41590-024-01875-0. Epub 2024 Jun 17. Nat Immunol. 2024. PMID: 38886592
Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing CD8(+) T cell functions, which requires a deeper understanding of CD8(+) T cells promoting HIV control. ...
Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing CD8(+) T cell functions, which requires a deep
The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress.
Fingerman DF, O'Leary DR, Hansen AR, Tran T, Harris BR, DeWeerd RA, Hayer KE, Fan J, Chen E, Tennakoon M, Meroni A, Szeto JH, Devenport J, LaVigne D, Weitzman MD, Shalem O, Bednarski J, Vindigni A, Zhao X, Green AM. Fingerman DF, et al. EMBO J. 2024 Jun 17. doi: 10.1038/s44318-024-00137-x. Online ahead of print. EMBO J. 2024. PMID: 38886582 Free article.
Mutational patterns caused by APOBEC3 cytidine deaminase activity are evident throughout human cancer genomes. In particular, the APOBEC3A family member is a potent genotoxin that causes substantial DNA damage in experimental systems and human tumors. ...Through an …
Mutational patterns caused by APOBEC3 cytidine deaminase activity are evident throughout human cancer genomes. In particular, the APO …
Bile acid-sensitive human norovirus strains are susceptible to sphingosine-1-phosphate receptor 2 inhibition.
Tenge V, Ayyar BV, Ettayebi K, Crawford SE, Hayes NM, Shen Y-T, Neill FH, Atmar RL, Estes MK. Tenge V, et al. J Virol. 2024 Jul 23;98(7):e0202023. doi: 10.1128/jvi.02020-23. Epub 2024 Jun 17. J Virol. 2024. PMID: 38884472
Human noroviruses (HuNoVs) are a diverse group of RNA viruses that cause endemic and pandemic acute viral gastroenteritis. Previously, we reported that many HuNoV strains require bile or bile acid (BA) to infect human jejunal intestinal enteroid cultures. BA was not
Human noroviruses (HuNoVs) are a diverse group of RNA viruses that cause endemic and pandemic acute viral gastroenteritis. Previously
Using neural biomarkers to personalize dosing of vagus nerve stimulation.
Berthon A, Wernisch L, Stoukidi M, Thornton M, Tessier-Lariviere O, Fortier-Poisson P, Mamen J, Pinkney M, Lee S, Sarkans E, Annecchino L, Appleton B, Garsed P, Patterson B, Gonshaw S, Jakopec M, Shunmugam S, Edwards T, Tukiainen A, Jennings J, Lajoie G, Hewage E, Armitage O. Berthon A, et al. Bioelectron Med. 2024 Jun 17;10(1):15. doi: 10.1186/s42234-024-00147-4. Bioelectron Med. 2024. PMID: 38880906 Free PMC article.
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer.
Lee HM, Muhammad N, Lieu EL, Cai F, Mu J, Ha YS, Cao G, Suchors C, Joves K, Chronis C, Li K, Ducker GS, Olszewski K, Cai L, Allison DB, Bachert SE, Ewing WR, Wong H, Seo H, Kim IY, Faubert B, Kim J, Kim J. Lee HM, et al. Nat Metab. 2024 Jun 14. doi: 10.1038/s42255-024-01066-z. Online ahead of print. Nat Metab. 2024. PMID: 38877143
Here we describe a KL-induced metabolic vulnerability associated with serine-glycine-one-carbon (SGOC) metabolism. Using RNA-seq and metabolomics data from human NSCLC, we uncovered that LKB1 loss enhanced SGOC metabolism via serine hydroxymethyltransferase (SHMT). ...
Here we describe a KL-induced metabolic vulnerability associated with serine-glycine-one-carbon (SGOC) metabolism. Using RNA-seq and metabol …