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Year Number of Results
1996 1
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2011 2
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2013 4
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64 results

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Page 1
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H. Li B, et al. Nat Commun. 2023 Jan 30;14(1):489. doi: 10.1038/s41467-023-36008-y. Nat Commun. 2023. PMID: 36717587 Free PMC article.
Mechanically, circSCMH1 increased the translocation of ubiquitination-modified fat mass and obesity-associated protein (FTO) into nucleus of endothelial cells (ECs), leading to m(6)A demethylation of phospholipid phosphatase 3 (Plpp3) mRNA and subsequently the increase of …
Mechanically, circSCMH1 increased the translocation of ubiquitination-modified fat mass and obesity-associated protein (FTO) into nucleus of …
Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells.
Montané-Romero ME, Martínez-Silva AV, Poot-Hernández AC, Escalante-Alcalde D. Montané-Romero ME, et al. Biol Open. 2023 Jan 1;12(1):bio059665. doi: 10.1242/bio.059665. Epub 2023 Jan 12. Biol Open. 2023. PMID: 36504260 Free PMC article.
Different lines of evidence suggest that PLPP3 could play a role in endoderm development. To approach this hypothesis, we used mouse embryonic stem cells (ESC) as a model to study Plpp3 function in self-renewal and the transition towards differentiation. ...PLPP3 …
Different lines of evidence suggest that PLPP3 could play a role in endoderm development. To approach this hypothesis, we used mouse …
Regulation of PLPP3 gene expression by NF-kappaB family transcription factors.
Mao G, Smyth SS, Morris AJ. Mao G, et al. J Biol Chem. 2019 Sep 20;294(38):14009-14019. doi: 10.1074/jbc.RA119.009002. Epub 2019 Jul 30. J Biol Chem. 2019. PMID: 31362988 Free PMC article.
However, the mechanisms regulating PLPP3 expression are not well understood. We show that the human PLPP3 promoter contains three functional NF-kappaB response elements. ...These findings indicate that up-regulation of PLPP3 during inflammation and atheroscle …
However, the mechanisms regulating PLPP3 expression are not well understood. We show that the human PLPP3 promoter contains th …
Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis.
Mueller PA, Yang L, Ubele M, Mao G, Brandon J, Vandra J, Nichols TC, Escalante-Alcalde D, Morris AJ, Smyth SS. Mueller PA, et al. Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2261-2272. doi: 10.1161/ATVBAHA.119.313056. Epub 2019 Sep 19. Arterioscler Thromb Vasc Biol. 2019. PMID: 31533471 Free PMC article.
PLPP3 encodes LPP3 (lipid phosphate phosphatase 3), a cell-surface enzyme that can regulate the availability of bioactive lysophopsholipids including lysophosphatidic acid (LPA). The protective allele of PLPP3 increases LPP3 expression during cell exposure to oxidiz …
PLPP3 encodes LPP3 (lipid phosphate phosphatase 3), a cell-surface enzyme that can regulate the availability of bioactive lysophopsho …
Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE(-/-) mice.
Busnelli M, Manzini S, Hilvo M, Parolini C, Ganzetti GS, Dellera F, Ekroos K, Jänis M, Escalante-Alcalde D, Sirtori CR, Laaksonen R, Chiesa G. Busnelli M, et al. Sci Rep. 2017 Mar 14;7:44503. doi: 10.1038/srep44503. Sci Rep. 2017. PMID: 28291223 Free PMC article.
The aim of the study was to investigate the effect of Plpp3 deletion on atherosclerosis development in mice. Because the constitutive deletion of Plpp3 in mice is lethal, conditional Plpp3 hepatocyte-specific null mice were generated by crossing floxed Plp …
The aim of the study was to investigate the effect of Plpp3 deletion on atherosclerosis development in mice. Because the constitutive …
Lipid phosphate phosphatase 3 in vascular pathophysiology.
Busnelli M, Manzini S, Parolini C, Escalante-Alcalde D, Chiesa G. Busnelli M, et al. Atherosclerosis. 2018 Apr;271:156-165. doi: 10.1016/j.atherosclerosis.2018.02.025. Epub 2018 Mar 2. Atherosclerosis. 2018. PMID: 29518748 Free article. Review.
In 2011, two genome-wide association studies have identified PLPP3 as a novel locus associated with coronary artery disease susceptibility. Shortly after these reports, tissue specific inactivation of PLPP3 in mice highlighted a specific role for LPP3 in vascular pa …
In 2011, two genome-wide association studies have identified PLPP3 as a novel locus associated with coronary artery disease susceptib …
Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration.
Gómez-López S, Martínez-Silva AV, Montiel T, Osorio-Gómez D, Bermúdez-Rattoni F, Massieu L, Escalante-Alcalde D. Gómez-López S, et al. Sci Rep. 2016 Apr 11;6:24028. doi: 10.1038/srep24028. Sci Rep. 2016. PMID: 27063549 Free PMC article.
PLPP3 modulates the levels of a range of bioactive lipids controlling fundamental cellular processes within the central nervous system. Here we show that PLPP3 is enriched in astroglial cells of the adult murine ventral midbrain. ...
PLPP3 modulates the levels of a range of bioactive lipids controlling fundamental cellular processes within the central nervous syste …
Roles for lysophosphatidic acid signaling in vascular development and disease.
Smyth SS, Kraemer M, Yang L, Van Hoose P, Morris AJ. Smyth SS, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Aug;1865(8):158734. doi: 10.1016/j.bbalip.2020.158734. Epub 2020 May 3. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32376340 Review.
The signaling effects of LPA can be terminated by integral membrane lipid phosphate phosphatases (LPP) that hydrolyze the lipid to receptor inactive products. Human genetic variants in PLPP3, that predict lower levels of LPP3, associate with risk for premature coronary art …
The signaling effects of LPA can be terminated by integral membrane lipid phosphate phosphatases (LPP) that hydrolyze the lipid to receptor …
64 results