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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1841 1
1852 2
1855 3
1856 1
1865 1
1866 1
1867 2
1871 1
1873 1
1874 1
1883 1
1886 1
1892 2
1899 1
1904 1
1905 3
1907 3
1908 4
1909 10
1910 12
1911 2
1913 2
1914 1
1915 3
1916 2
1918 2
1919 1
1921 3
1922 5
1923 4
1924 6
1925 6
1926 8
1927 5
1928 9
1929 4
1930 9
1931 6
1932 18
1933 12
1934 8
1935 6
1936 5
1937 5
1938 5
1939 5
1940 2
1941 6
1942 9
1943 4
1944 9
1945 17
1946 54
1947 71
1948 53
1949 70
1950 54
1951 48
1952 57
1953 64
1954 64
1955 52
1956 77
1957 101
1958 98
1959 148
1960 179
1961 220
1962 328
1963 696
1964 1011
1965 946
1966 1246
1967 1453
1968 1674
1969 1887
1970 1842
1971 2078
1972 2174
1973 2202
1974 2171
1975 2273
1976 2014
1977 1960
1978 1870
1979 1832
1980 1779
1981 1747
1982 1818
1983 2051
1984 2175
1985 2167
1986 2307
1987 2228
1988 2274
1989 2536
1990 2601
1991 2738
1992 2735
1993 2822
1994 2918
1995 2867
1996 2927
1997 2932
1998 2887
1999 3050
2000 3291
2001 3274
2002 3433
2003 3589
2004 3732
2005 4233
2006 4643
2007 4825
2008 5017
2009 5269
2010 5777
2011 6261
2012 6797
2013 7169
2014 7686
2015 8020
2016 8149
2017 8314
2018 8775
2019 9248
2020 10956
2021 11781
2022 11406
2023 10760
2024 4637

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227,361 results

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Page 1
Lactate: the ugly duckling of energy metabolism.
Rabinowitz JD, Enerbäck S. Rabinowitz JD, et al. Nat Metab. 2020 Jul;2(7):566-571. doi: 10.1038/s42255-020-0243-4. Epub 2020 Jul 20. Nat Metab. 2020. PMID: 32694798 Free PMC article. Review.
Whereas microbes also generate other fermentation products, such as ethanol or acetone, lactate dominates in mammals. Lactate production increases when the demand for ATP and oxygen exceeds supply, as occurs during intense exercise and ischaemia. The build-up of …
Whereas microbes also generate other fermentation products, such as ethanol or acetone, lactate dominates in mammals. Lactate
The Science and Translation of Lactate Shuttle Theory.
Brooks GA. Brooks GA. Cell Metab. 2018 Apr 3;27(4):757-785. doi: 10.1016/j.cmet.2018.03.008. Cell Metab. 2018. PMID: 29617642 Free article. Review.
Once thought to be a waste product of anaerobic metabolism, lactate is now known to form continuously under aerobic conditions. ..."Lactate shuttle" (LS) concepts describe the roles of lactate in delivery of oxidative and gluconeogenic substrates as well as i …
Once thought to be a waste product of anaerobic metabolism, lactate is now known to form continuously under aerobic conditions. ..." …
Lactate: Friend or Foe.
Hall MM, Rajasekaran S, Thomsen TW, Peterson AR. Hall MM, et al. PM R. 2016 Mar;8(3 Suppl):S8-S15. doi: 10.1016/j.pmrj.2015.10.018. PM R. 2016. PMID: 26972271 Review.
Lactic acid has played an important role in the traditional theory of muscle fatigue and limitation of endurance exercise performance. ...This review will provide the sports medicine clinician with an understanding of contemporary lactate theories, including
Lactic acid has played an important role in the traditional theory of muscle fatigue and limitation of endurance exercise perf
Appropriate Clinical Use of Lactate Measurements.
Pino RM, Singh J. Pino RM, et al. Anesthesiology. 2021 Apr 1;134(4):637-644. doi: 10.1097/ALN.0000000000003655. Anesthesiology. 2021. PMID: 33332524 Free article. Review. No abstract available.
Lactate Metabolism, Signaling, and Function in Brain Development, Synaptic Plasticity, Angiogenesis, and Neurodegenerative Diseases.
Wu A, Lee D, Xiong WC. Wu A, et al. Int J Mol Sci. 2023 Aug 29;24(17):13398. doi: 10.3390/ijms241713398. Int J Mol Sci. 2023. PMID: 37686202 Free PMC article. Review.
The astrocyte-neuron lactate-shuttle hypothesis states that lactate, once released into the extracellular space by astrocytes, can be up-taken and metabolized by neurons. This review focuses on this hypothesis, highlighting lactate's emerging role in t …
The astrocyte-neuron lactate-shuttle hypothesis states that lactate, once released into the extracellular space by astrocytes, …
The value of blood lactate kinetics in critically ill patients: a systematic review.
Vincent JL, Quintairos E Silva A, Couto L Jr, Taccone FS. Vincent JL, et al. Crit Care. 2016 Aug 13;20(1):257. doi: 10.1186/s13054-016-1403-5. Crit Care. 2016. PMID: 27520452 Free PMC article. Review.
We collected data on the number of patients, timing of lactate measurements, minimum lactate level needed for inclusion if present, and suggested time interval for predictive use. ...The value of lactate kinetics appears to be valid regardless of the initial …
We collected data on the number of patients, timing of lactate measurements, minimum lactate level needed for inclusion if pre …
Effect of water-based recovery on blood lactate removal after high-intensity exercise.
Lucertini F, Gervasi M, D'Amen G, Sisti D, Rocchi MBL, Stocchi V, Benelli P. Lucertini F, et al. PLoS One. 2017 Sep 6;12(9):e0184240. doi: 10.1371/journal.pone.0184240. eCollection 2017. PLoS One. 2017. PMID: 28877225 Free PMC article. Clinical Trial.
Blood lactate concentration was measured 8 times during each recovery condition and lactate clearance was modeled over a negative exponential function using non-linear regression. ...Non-linear regression parameters (coefficients of the exponential decay of lacta
Blood lactate concentration was measured 8 times during each recovery condition and lactate clearance was modeled over a negat …
Lactate shuttles in nature.
Brooks GA. Brooks GA. Biochem Soc Trans. 2002 Apr;30(2):258-64. doi: 10.1042/bst0300258. Biochem Soc Trans. 2002. PMID: 12023861 Review.
Lactate uptake by mitochondria and pyruvate-lactate exchange in peroxisomes are examples of intracellular lactate shuttles. ...The mitochondrial lactate-pyruvate transporter appears to work in conjunction with mitochondrial lactate dehydrogenase
Lactate uptake by mitochondria and pyruvate-lactate exchange in peroxisomes are examples of intracellular lactate shutt
Lactate metabolism in anoxic turtles: an integrative review.
Warren DE, Jackson DC. Warren DE, et al. J Comp Physiol B. 2008 Feb;178(2):133-48. doi: 10.1007/s00360-007-0212-1. Epub 2007 Oct 17. J Comp Physiol B. 2008. PMID: 17940776 Review.
Painted turtles can accumulate lactic acid to extremely high concentrations during long-term anoxic submergence, with plasma lactate exceeding 200 mmol l(-1). ...The topics reviewed include analyses of lactate's fate during recovery, the effects …
Painted turtles can accumulate lactic acid to extremely high concentrations during long-term anoxic submergence, with plasma …
Lactate--a signal coordinating cell and systemic function.
Philp A, Macdonald AL, Watt PW. Philp A, et al. J Exp Biol. 2005 Dec;208(Pt 24):4561-75. doi: 10.1242/jeb.01961. J Exp Biol. 2005. PMID: 16326938 Review.
Since its first documented observation in exhausted animal muscle in the early 19th century, the role of lactate (lactic acid) has fascinated muscle physiologists and biochemists. ...This review is structured in three sections, the first covering pertinent to …
Since its first documented observation in exhausted animal muscle in the early 19th century, the role of lactate (lactic ac
227,361 results
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