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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis.
Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, Wang Y, Brzoska P, Kong B, Li R, West RB, van de Vijver MJ, Sukumar S, Chang HY. Gupta RA, et al. Among authors: chang hy. Nature. 2010 Apr 15;464(7291):1071-6. doi: 10.1038/nature08975. Nature. 2010. PMID: 20393566 Free PMC article.
Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.
Mazumdar C, Shen Y, Xavy S, Zhao F, Reinisch A, Li R, Corces MR, Flynn RA, Buenrostro JD, Chan SM, Thomas D, Koenig JL, Hong WJ, Chang HY, Majeti R. Mazumdar C, et al. Among authors: chang hy. Cell Stem Cell. 2015 Dec 3;17(6):675-688. doi: 10.1016/j.stem.2015.09.017. Epub 2015 Oct 22. Cell Stem Cell. 2015. PMID: 26607380 Free PMC article.
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues.
Corces MR, Trevino AE, Hamilton EG, Greenside PG, Sinnott-Armstrong NA, Vesuna S, Satpathy AT, Rubin AJ, Montine KS, Wu B, Kathiria A, Cho SW, Mumbach MR, Carter AC, Kasowski M, Orloff LA, Risca VI, Kundaje A, Khavari PA, Montine TJ, Greenleaf WJ, Chang HY. Corces MR, et al. Among authors: chang hy. Nat Methods. 2017 Oct;14(10):959-962. doi: 10.1038/nmeth.4396. Epub 2017 Aug 28. Nat Methods. 2017. PMID: 28846090 Free PMC article.
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.
Mumbach MR, Satpathy AT, Boyle EA, Dai C, Gowen BG, Cho SW, Nguyen ML, Rubin AJ, Granja JM, Kazane KR, Wei Y, Nguyen T, Greenside PG, Corces MR, Tycko J, Simeonov DR, Suliman N, Li R, Xu J, Flynn RA, Kundaje A, Khavari PA, Marson A, Corn JE, Quertermous T, Greenleaf WJ, Chang HY. Mumbach MR, et al. Among authors: chang hy. Nat Genet. 2017 Nov;49(11):1602-1612. doi: 10.1038/ng.3963. Epub 2017 Sep 25. Nat Genet. 2017. PMID: 28945252 Free PMC article.
Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons.
Wapinski OL, Lee QY, Chen AC, Li R, Corces MR, Ang CE, Treutlein B, Xiang C, Baubet V, Suchy FP, Sankar V, Sim S, Quake SR, Dahmane N, Wernig M, Chang HY. Wapinski OL, et al. Among authors: chang hy. Cell Rep. 2017 Sep 26;20(13):3236-3247. doi: 10.1016/j.celrep.2017.09.011. Cell Rep. 2017. PMID: 28954238 Free PMC article.
Challenges and recommendations for epigenomics in precision health.
Carter AC, Chang HY, Church G, Dombkowski A, Ecker JR, Gil E, Giresi PG, Greely H, Greenleaf WJ, Hacohen N, He C, Hill D, Ko J, Kohane I, Kundaje A, Palmer M, Snyder MP, Tung J, Urban A, Vidal M, Wong W. Carter AC, et al. Among authors: chang hy. Nat Biotechnol. 2017 Dec 8;35(12):1128-1132. doi: 10.1038/nbt.4030. Nat Biotechnol. 2017. PMID: 29220033 Free PMC article. No abstract available.
2,118 results