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Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium.
Felice VD, O'Gorman DM, O'Brien NM, Hyland NP. Felice VD, et al. Nutrients. 2018 Jul 17;10(7):912. doi: 10.3390/nu10070912. Nutrients. 2018. PMID: 30018220 Free PMC article.
However, the in vitro bioaccessibility and bioavailability of Aquamin-Mg in comparison with other supplement sources of magnesium has yet to be tested. ...Magnesium concentration was measured by atomic absorption spectrophotometry (AAS). Results: Magnesium recovery from bo …
However, the in vitro bioaccessibility and bioavailability of Aquamin-Mg in comparison with other supplement sources of magnesium has …
Evidence that marine-derived, multi-mineral, Aquamin inhibits the NF-kappaB signaling pathway in vitro.
O'Gorman DM, O'Carroll C, Carmody RJ. O'Gorman DM, et al. Phytother Res. 2012 Apr;26(4):630-2. doi: 10.1002/ptr.3601. Epub 2011 Oct 28. Phytother Res. 2012. PMID: 22034197
This study describes an anti-inflammatory role for Aquamin in inhibiting NF-kappaB activation through reducing the phosphorylation and degradation of its upstream inhibitor IkappaBalpha. Aquamin inhibition of NF-kappaB activation results in significantly reduced cyc …
This study describes an anti-inflammatory role for Aquamin in inhibiting NF-kappaB activation through reducing the phosphorylation an …
The bioaccessibility and tolerability of marine-derived sources of magnesium and calcium.
Dowley A, Long-Smith CM, Demehin O, Nolan Y, O'Connell S, O'Gorman DM. Dowley A, et al. Methods. 2024 Jun;226:28-34. doi: 10.1016/j.ymeth.2024.04.009. Epub 2024 Apr 10. Methods. 2024. PMID: 38608850 Free article. Clinical Trial.
In this study, we examine two different marine-derived multimineral products as potential dietary supplements. Aquamin-Mg, sourced from seawater is rich in magnesium (12%), and Aquamin F, a seaweed-derived multimineral is rich in calcium (32%). ...The second experim …
In this study, we examine two different marine-derived multimineral products as potential dietary supplements. Aquamin-Mg, sourced fr …
The marine-derived, multi-mineral formula, Aquamin, enhances mineralisation of osteoblast cells in vitro.
O'Gorman DM, Tierney CM, Brennan O, O'Brien FJ. O'Gorman DM, et al. Phytother Res. 2012 Mar;26(3):375-80. doi: 10.1002/ptr.3561. Epub 2011 Jul 12. Phytother Res. 2012. PMID: 21751268
The aim of this study was to evaluate the effect of Aquamin on osteoblastic behaviour and mineralisation in a pre-osteoblastic cell line. Cell number and metabolic activity were assessed using Hoescht DNA and AlamarBlue assays respectively. Osteogenic differentiation was m …
The aim of this study was to evaluate the effect of Aquamin on osteoblastic behaviour and mineralisation in a pre-osteoblastic cell l …
Cell-Matrix Interactions Contribute to Barrier Function in Human Colon Organoids.
Varani J, McClintock SD, Aslam MN. Varani J, et al. Front Med (Lausanne). 2022 Mar 10;9:838975. doi: 10.3389/fmed.2022.838975. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35360746 Free PMC article.
The effects of Aquamin on cell-matrix adhesion protein expression were determined in a proteomic screen and by Western blotting. ...TEER values were higher in the presence of Aquamin than they were under control conditions. The blocking antibody reduced TEER values …
The effects of Aquamin on cell-matrix adhesion protein expression were determined in a proteomic screen and by Western blotting. ...T …
The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D.
Widaa A, Brennan O, O'Gorman DM, O'Brien FJ. Widaa A, et al. Phytother Res. 2014 May;28(5):678-84. doi: 10.1002/ptr.5038. Epub 2013 Jul 19. Phytother Res. 2014. PMID: 23873476
The combination of Aquamin and Vitamin D3 yielded a significant increase in ALP and mineralisation over Aquamin alone and the standard osteogenic control +/- Vitamin D3. This study demonstrates that Aquamin aids osteogenesis, and that its osteogenic response …
The combination of Aquamin and Vitamin D3 yielded a significant increase in ALP and mineralisation over Aquamin alone and the …
Evidence that the marine-derived multi-mineral Aquamin has anti-inflammatory effects on cortical glial-enriched cultures.
Ryan S, O'Gorman DM, Nolan YM. Ryan S, et al. Phytother Res. 2011 May;25(5):765-7. doi: 10.1002/ptr.3309. Epub 2010 Oct 26. Phytother Res. 2011. PMID: 21520469
The aim of this study was to evaluate the anti-inflammatory potential of Aquamin in lipopolysaccharide-stimulated, glial-enriched primary cultures of rat cortex. It is reported that Aquamin prevented lipopolysaccharide-induced secretion of tumor necrosis factor-alph …
The aim of this study was to evaluate the anti-inflammatory potential of Aquamin in lipopolysaccharide-stimulated, glial-enriched pri …
Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute.
Brennan O, Stenson B, Widaa A, O Gorman DM, O Brien FJ. Brennan O, et al. J Mech Behav Biomed Mater. 2015 Jul;47:114-123. doi: 10.1016/j.jmbbm.2015.03.015. Epub 2015 Apr 1. J Mech Behav Biomed Mater. 2015. PMID: 25884141
A fabrication process was developed to incorporate Aquamin into scaffolds to produce collagen-Aquamin (CollAqua) scaffolds at two different Aquamin concentrations, 100F or 500F (equivalent weight% of collagen or five times the weight of collagen respectively) …
A fabrication process was developed to incorporate Aquamin into scaffolds to produce collagen-Aquamin (CollAqua) scaffolds at …
A multi-mineral intervention to counter pro-inflammatory activity and to improve the barrier in human colon organoids.
Varani J, McClintock SD, Nadeem DM, Harber I, Zeidan D, Aslam MN. Varani J, et al. Front Cell Dev Biol. 2023 Jul 5;11:1132905. doi: 10.3389/fcell.2023.1132905. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37476158 Free PMC article.
Several of these were significantly decreased with Aquamin() alone but only a modest decrease in a subset of these proteins was detected by Aquamin() in the presence of LPS-cytokines. ...When provided alone, Aquamin() strongly upregulated proteins that contri …
Several of these were significantly decreased with Aquamin() alone but only a modest decrease in a subset of these proteins was detec …
A Multi-Mineral Intervention to Modulate Colonic Mucosal Protein Profile: Results from a 90-Day Trial in Human Subjects.
Aslam MN, McClintock SD, Jawad-Makki MAH, Knuver K, Ahmad HM, Basrur V, Bergin IL, Zick SM, Sen A, Turgeon DK, Varani J. Aslam MN, et al. Nutrients. 2021 Mar 14;13(3):939. doi: 10.3390/nu13030939. Nutrients. 2021. PMID: 33799486 Free PMC article. Clinical Trial.
Increased p21 expression was observed with both calcium and Aquamin(). In proteomic screen, Aquamin() treatment resulted in many more proteins being upregulated (including pro-apoptotic, cytokeratins, cell-cell adhesion molecules, and components of the basement memb …
Increased p21 expression was observed with both calcium and Aquamin(). In proteomic screen, Aquamin() treatment resulted in ma …
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